Results 71 to 80 of about 1,055 (154)

New <i>N</i>-Arylpiperazine-Based Compounds as Potential Inhibitors of Purinergic P2X7-Associated Signaling. [PDF]

Life (Basel)
Greifová G, Hrčka Dubničková M, Nádaská D, Šandrik R, Kapustíková I, Švajdlenka E, Pisárčik M, Csöllei J, Malík I.   +8 more
europepmc   +1 more source

In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone as Promising Cyclooxygenase Inhibitors. [PDF]

Int J Mol Sci, 2021
Peregrym K, Szczukowski Ł, Wiatrak B, Potyrak K, Czyżnikowska Ż, Świątek P.   +5 more
europepmc   +1 more source

Anti-Inflammatory Activity of 1,2-Benzothiazine 1,1-Dioxide Derivatives. [PDF]

Pharmaceuticals (Basel)
Szczęśniak-Sięga BM, Topolska I.
europepmc   +1 more source

Novel serotonin 5-HT_2A receptor antagonists derived from 4-phenylcyclohexane-5-spiro-and 5-methyl-5-phenyl-hydantoin, for use as potential antiplatelet agents. [PDF]

Pharmacol Rep, 2021
Czopek A, Kubacka M, Bucki A, Siwek A, Filipek B, Pawłowski M, Kołaczkowski M.   +6 more
europepmc   +1 more source

Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey. [PDF]

Pharmaceuticals (Basel)
Ghafir El Idrissi I, Santo A, Lacivita E, Leopoldo M.   +3 more
europepmc   +1 more source

Hybrid design reveals a dopamine D3R ligand with promising in vitro ADME properties. [PDF]

Bioorg Chem
Namballa HK, Dorogan M, Patra S, Gudipally A, Xie L, Xie L, Harding WW.   +6 more
europepmc   +1 more source

Heat Shock Proteins HSPA1 and HSP90AA1 Are Upregulated in Colorectal Polyps and Can Be Targeted in Cancer Cells by Anti-Inflammatory Oxicams with Arylpiperazine Pharmacophore and Benzoyl Moiety Substitutions at Thiazine Ring. [PDF]

Biomolecules, 2021
Szczuka I, Wierzbicki J, Serek P, Szczęśniak-Sięga BM, Krzystek-Korpacka M.   +4 more
europepmc   +1 more source

The structure of the dopamine D₃ receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology. [PDF]

Sci Adv
Hadas Yardeni E, Kiss DJ, Sanchez J, Shavit K, Szepesi Kovács D, Egyed A, Vogt CD, Gaitonde SA, Glenn J, Canals M, Bouvier M, Newman AH, Lane JR, Keserű GM, Shalev-Benami M.   +14 more
europepmc   +1 more source

Design and Synthesis of a Novel 4-aryl-N-(2-alkoxythieno [2,3-b]pyrazine-3-yl)-4-arylpiperazine-1-carboxamide DGG200064 Showed Therapeutic Effect on Colon Cancer through G2/M Arrest. [PDF]

Pharmaceuticals (Basel), 2022
Lee ES, Kim N, Kang JH, Abdildinova A, Lee SH, Lee MH, Kang NS, Koo TS, Kim SY, Gong YD.   +9 more
europepmc   +1 more source

Recent advances in the synthesis of antidepressant derivatives: pharmacologic insights for mood disorders. [PDF]

3 Biotech
Gupta JK, Singh K, Bhatt A, Porwal P, Rani R, Dubey A, Jain D, Rai SN.   +7 more
europepmc   +1 more source