Results 51 to 60 of about 1,089 (172)

Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF‐7 and MDA‐MB‐231

Journal of Chemistry, Volume 2017, Issue 1, 2017., 2017
Recent drug discovery efforts are highly focused towards identification, design, and synthesis of small molecules as anticancer agents. With this aim, we recently designed and synthesized novel compounds with high efficacy and specificity for the treatment of breast tumors.
Vincenza Barresi, Carmela Bonaccorso, Domenico A. Cristaldi, Maria N. Modica, Nicolò Musso, Valeria Pittalà, Loredana Salerno, Cosimo G. Fortuna, Oliver Sutcliffe   +8 more
wiley   +1 more source

Design, Synthesis and 5-HT_1A Binding Affinity of N-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)tricyclo[3.3.1.1^3,7]decan-1-amine and N-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)-3,5-dimethyl-tricylo[3.3.1.1^3,7]decan-1-amine

Molbank, 2022
Based on previously highlighted structural features, the development of highly selective 5-HT1A receptor inhibitors is closely linked to the incorporation of a 4-alkyl-1-arylpiperazine scaffold on them.
Grigoris Zoidis, María Isabel Loza, Marco Catto   +2 more
doaj   +1 more source

Copper Complexes with Arylated Triethylenetetramine Ligands: Reactivity Toward Dioxygen and Peroxides

European Journal of Inorganic Chemistry, Volume 29, Issue 17, 17 June 2026.
Here, we describe new Cu(I)/Cu(II) complexes based on arylated tren ligands and investigate their reactivity toward O2 and peroxides. Low‐temperature–stopped flow studies revealed the formation of transient copper–oxygen species, including superoxido, hydroperoxido, and alkylperoxido intermediates.
Chiara Eleonora Campi, Christian Würtele, Siegfried Schindler   +2 more
wiley   +1 more source

Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides

International Journal of Medicinal Chemistry, Volume 2014, Issue 1, 2014., 2014
The unusual structure and chemical composition of the mycobacterial cell wall, the tedious duration of therapy, and resistance developed by the microorganism have made the recurrence of the disease multidrug resistance and extensive or extreme drug resistance.
D. I. Ugwu, B. E. Ezema, F. U. Eze, D. I. Ugwuja, Arie Zask   +4 more
wiley   +1 more source

Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines

Journal of Chemistry, Volume 8, Issue 3, Page 1044-1051, 2011., 2011
A series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5‐HTP induced head twitches (5‐HT2A antagonism) and catalepsy studies in albino mice.
Sushil Kumar, A. K. Wahi, Ranjit Singh
wiley   +1 more source

Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT1A Serotonin Receptors

Molecules, 2012
A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors.
Ramiro Araya-Maturana, Claudio Saitz Barría, Gerald Zapata-Torres, C. David Pessoa-Mahana, Gonzalo Recabarren-Gajardo, Jenny Fiedler Temer, Hernán Pessoa-Mahana   +6 more
doaj   +1 more source

Determination of Acid Dissociation Constants of Some 2-(3H) –Benzoxazolone Derivatives by UV–Vis Spectrophotometry [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The acid dissociation constant values of some 2-(3H)-benzoxazolone derivatives were determined in buffered solutions by using the UV-Vis spectrophotometric method.
Semra Altunterim Erkan, Hayati Celik, Banu Kesanlı   +2 more
doaj   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties

, 2014
Many known 5-HT7 ligands contain either a serotonin-like or an arylpiperazine structure that, in published SAR studies, are generally supposed to bind the same receptor pocket. Conversely, we explored the hypothesis that two such moieties can co-exist in
Riccioni T., Cabri W., PALA, Daniele, Bartolucci S., Mor M., Tarzia G., Borsini F., MOR, Marco, Minetti P., Marzi M., Pala D., Cabri W, Spadoni G., Rivara S., Celona D., RIVARA, Silvia, Bedini A.   +16 more
core   +2 more sources

Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

Molecules, 2009
A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against ...
David Collu, Roberta Loddo, Cristina Ibba, Laura Ester Marongiu, Paolo La Colla, Izabela Dybala, Anna E. Koziol, Marta Struga, Jerzy Kossakowski, Magdalena Pakosinska-Parys   +9 more
doaj   +1 more source