Results 61 to 70 of about 957 (180)

Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT1A Serotonin Receptors

Molecules, 2012
A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors.
Ramiro Araya-Maturana, Claudio Saitz Barría, Gerald Zapata-Torres, C. David Pessoa-Mahana, Gonzalo Recabarren-Gajardo, Jenny Fiedler Temer, Hernán Pessoa-Mahana   +6 more
doaj   +1 more source

Ionization constants and partition coefficients of 1-arylpiperazine derivatives

Journal of Pharmacy and Pharmacology, 1985
AbstractThe ionization constant (pKa and liposolubilities (log P) of fourteen 1-arylpiperazines were determined by n-octanol/buffer partition. pKa varied little across the entire series. Log P values ranged from less than 1 to about 2 for the highly lipophilic derivatives of the preset series.
S, Caccia, M H, Fong, R, Urso
openaire   +2 more sources

Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines

Journal of Chemistry, Volume 8, Issue 3, Page 1044-1051, 2011., 2011
A series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5‐HTP induced head twitches (5‐HT2A antagonism) and catalepsy studies in albino mice.
Sushil Kumar, A. K. Wahi, Ranjit Singh
wiley   +1 more source

Determination of Acid Dissociation Constants of Some 2-(3H) –Benzoxazolone Derivatives by UV–Vis Spectrophotometry [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The acid dissociation constant values of some 2-(3H)-benzoxazolone derivatives were determined in buffered solutions by using the UV-Vis spectrophotometric method.
Semra Altunterim Erkan, Hayati Celik, Banu Kesanlı   +2 more
doaj   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Short Synthesis of Enantiopure trans-3-Arylpiperazine-2-carboxylic Acid Derivatives via Diaza-Cope Rearrangement

, 2016
An efficient synthetic method was developed for the construction of enantiomerically pure trans-3-arylpiperazine-2-carboxylic acid derivatives using diaza-Cope rearrangement (DCR) as a key step starting from (R,R)/(S,S)-1,2-bis(2-hydroxyphenyl)-1,2 ...
Soon Ho Kwon (2062855), Jik Chin (2062858), Sang Min Lee (507437), B. Moon Kim (1608127), Sang Moon Byun (2062852)   +4 more
core   +1 more source

In Vitro approach for identification of a leading cytochrome P450 isoenzyme responsible for biotransformation of novel arylpiperazine drug candidates and their inhibition potency towards CYP3A4.

, 2020
Presented article is a follow-up study of previous work, published in PLoS ONE in 2015 regarding metabolic stability of arylpiperazine derivatives, a very promising group of novel antidepressants.
Król, Marek, Bączek, Tomasz, Ulenberg, Szymon, Belka, Mariusz, Georgiev, Paweł, Herold, Franciszek   +5 more
core   +1 more source

Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

Molecules, 2009
A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against ...
David Collu, Roberta Loddo, Cristina Ibba, Laura Ester Marongiu, Paolo La Colla, Izabela Dybala, Anna E. Koziol, Marta Struga, Jerzy Kossakowski, Magdalena Pakosinska-Parys   +9 more
doaj   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)-Induced Mitochondrial Damage and Apoptosis

, 2012
The protective ability of novel arylpiperazine-based dopaminergic ligands against nitric oxide (NO)-mediated neurotoxicity is investigated. The most potent neuroprotective arylpiperazine identified during the study was N-{4-[2-(4-phenyl-piperazin-1-yl ...
Trajković, Vladimir, Vucicevic, Ljubica, Janjetovic, Kristina, Zogovic, Nevena, Vukic Soskic, Vladimir Trajkovic, Kostić Rajačić, Slađana, Gordana Tovilovic, Andre Schrattenholz, Isaković, Aleksandra, Šoškić, Vukić, Maja Misirkic‐Marjanovic, Kostić-Rajačić, Slađana, Tovilović-Kovačević, Gordana, Tovilović, Gordana, Misirkić-Marjanović, Maja, Ljubica Vucicevic, Schrattenholz, Andre, Nevena Zogovic, Kristina Janjetovic, Sladjana Kostic‐Rajacic, Misirkić Marjanović, Maja, Aleksandra Isakovic, Harhaji-Trajković, Ljubica, Ljubica Harhaji‐Trajkovic   +24 more
core   +1 more source