Results 81 to 90 of about 957 (180)

A chemometric study of the 5-HT1A receptor affinities presented by arylpiperazine compounds

, 2008
Arylpiperazine compounds are promising 5-HT1A receptor ligands that can contribute for accelerating the onset of therapeutic effect of selective serotonin reuptake inhibitors. In the present work, the chemometric methods HCA, PCA, KNN, SIMCA and PLS were
WEBER, Karen C., SILVA, Alberico B. F. da   +1 more
core   +1 more source

The Structure–Antimicrobial Activity Relationships of a Promising Class of the Compounds Containing the N-Arylpiperazine Scaffold

Molecules, 2016
This research was focused on in silico characterization and in vitro biological testing of the series of the compounds carrying a N-arylpiperazine moiety.
Ivan Malík, Jozef Csöllei, Josef Jampílek, Lukáš Stanzel, Iveta Zadražilová, Jan Hošek, Šárka Pospíšilová, Alois Čížek, Aidan Coffey, Jim O’Mahony   +9 more
doaj   +1 more source

Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides [PDF]

Journal of the Serbian Chemical Society
Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most noted as a neurotransmitter, an activator of the utmost subtype family of G-protein- coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors treat central nervous system
Andrić Deana B., Dukić-Stefanović Slađana, Krunić Mihajlo J., Jevtić Ivana I., Penjišević Jelena Z., Šukalović Vladimir B., Kostić-Rajačić Slađana   +6 more
doaj   +1 more source

Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
In our endeavour towards the development of effective anticancer therapeutics, a novel series of isoxazole-piperazine hybrids were synthesized and evaluated for their cytotoxic activities against human liver (Huh7 and Mahlavu) and breast (MCF-7) cancer ...
Burcu Çalışkan, Esra Sinoplu, Kübra İbiş, Ece Akhan Güzelcan, Rengül Çetin Atalay, Erden Banoglu   +5 more
doaj   +1 more source

New Imide 5-HT1A Receptor Ligands – Modification of Terminal Fragment Geometry

Molecules, 2004
Two sets of new o-methoxyphenylpiperazine (MPP; series a) and 1,2,3,4-tetrahydroisoquinoline (THIQ; series b) derivatives, containing various imide moietiesderived from NAN190, were synthesized and evaluated in vitro for their ability to bind tothe ...
Ryszard Bugno, Aneta Kozioł, Beata Duszyńska, Maria J. Mokrosz, Andrzej J. Bojarski   +4 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Novel 5-HT7receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides

, 2004
A series of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides was synthesized and evaluated for their interactions with the constitutively active 5-HT7 receptor.
Schmidt, A.W., Sprouse, J.S., Vermeulen, ES, Grol, Cor, Wikstrom, HV, Wikström, H.V, Sprouse, JS, van Smeden, M, Grol, CJ, Schmidt, AW, Vermeulen, E.S   +10 more
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Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents

, 2017
Background: Protease activated receptor-1 (PAR1) is a G-coupled receptor activated by α-thrombin and other proteases. Several reports have demonstrated the PAR1 involvement in tumorigenesis and tumor progression.
CORVINO, ANGELA, Zotti, Andrea Ilaria, CALIENDO, GIUSEPPE, PERISSUTTI, ELISA, CIRINO, GIUSEPPE, MAGLI, ELISA, FRECENTESE, FRANCESCO, Terranova Barberio, Manuela, Di Gennaro, Elena, SEVERINO, BEATRICE, Iannelli, Federica, SANTAGADA, VINCENZO, FIORINO, FERDINANDO, ROVIEZZO, FIORENTINA, BUDILLON, Alfredo   +14 more
core   +1 more source

Modeling interactions of α1a adrenergic receptor and different arylpiperazine ligands

, 2012
Molecular modelling studies were undertaken in order to identify key interactions of selected ligands with α1A adrenergic receptor, responsible for their binding and presumably receptor activation. The previously made model of α1A adrenergic receptor was
Senćanski, Milan V., Kostić-Rajačić, Slađana, Andrić, Deana, Kostić Rajačić, Slađana, Šukalović, Vladimir, Sencanski, M.V., Senćanski, Milan, Došen-Mićović, Ljiljana, Šoškić, Vukić, Roglić, Goran   +9 more
core  

Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT(1A)/D-2 affinity as potential atypical antipsychotics

, 1998
Since it was known that 5HT properties (5HT(1A) agonism or 5HT(2A) antagonism) combined with D-2 antagonism may lead to atypical antipsychotic drugs, a series of 19 benzothiazolin-2-one and benzoxazin-3-one derivatives possessing the arylpiperazine ...
Rettori, MC, Caignard, DH., Guardiola-Lemaitre, B, Pfeiffer, B, Poupaert, Jacques, Diouf, O., Renard, P., Depreux, P., Lesieur, D., Taverne, T   +9 more
core   +1 more source