Results 101 to 110 of about 25,056,579 (316)
Arylsulfatase activity in marine polychaetes [PDF]
, 1984 Marine polychaetes, collected from the Vellar Estuary exhibited arylsulfatase activity. Lumbriconeries sp. Polydora sp. Monojis sp. and Heteromastus sp. were selected for this study. Of these, Heteromastus sp. showed maximum enzymatic activity and it has
Dhevendaran, K.
core
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.We identified and validated 25 causal protein targets linked to Parkinson's disease (PD) onset and progression using proteomic and genetic analyses. Using plasma and brain large‐scale pQTL datasets, we conducted proteome‐wide association studies (PWAS) and Mendelian randomization (MR) to assess causality.
Chenhao Gao +13 more
wiley +1 more source
Medicine in Drug Discovery, 2020 Aims: Minoxidil is a hair growth drug for treating androgenetic alopecia. Although minoxidil is generally administered as a topical formulation, this prodrug must be converted to its active form (minoxidil sulfate) by sulfotransferase in hair follicle ...
Mio Ichida +4 more
doaj
Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction [PDF]
BioImpacts, 2019 Introduction: Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease, is a diverse clinical entity that occurs after podocyte injury.
Shiva Kalantari +5 more
doaj +1 more source
Restricted-sum-dominant sets [PDF]
arXiv, 2017 Let $A$ be a nonempty finite subset of an additive abelian group $G$. Define $A + A := \{a + b : a, b \in A\}$ and $A \dotplus A := \{a + b : a, b \in A~\text{and}~ a \neq b\}$. The set $A$ is called a {\em sum-dominant (SD) set} if $|A + A| > |A - A|$, and it is called a {\em restricted sum-domonant (RSD) set} if $|A \dotplus A| > |A - A|$.
arxiv
Arylsulfatase K, a Novel Lysosomal Sulfatase [PDF]
Journal of Biological Chemistry, 2013 The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation.
Wiegmann, Elena +5 more
openaire +2 more sources
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.The pre‐ADMET properties of 5‐(3′,4′‐dihydroxyphenyl)‐γ‐valerolactone (VL) are evaluated for the first time. VL is rapidly metabolized and absorbed as its sulfate phase II conjugate (valerolactone sulfate). In the human S9 liver fraction, VL is metabolized into glucuronic phase II conjugates.
Larissa Della Vedova +9 more
wiley +1 more source
Lead toxicity and genetics in Flint, MI [PDF]
, 2018 It has been well established that lead poisoning, as defined by the CDC as blood lead levels (BLLs) at or above 5 μg/dl, can lead to long-term neurotoxic effects in children and requires immediate treatment.
Housman, David E +2 more
core +1 more source
Arylsulfatase A pseudodeficiency: loss of a polyadenylylation signal and N-glycosylation site.
Proceedings of the National Academy of Sciences of the United States of America, 1989 Metachromatic leukodystrophy is a metabolic disorder caused by the deficiency of arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency was introduced. The arylsulfatase
V. Gieselmann +4 more
semanticscholar +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.Abstract INTRODUCTION Biomarkers (BMs) are valuable tools to facilitate early diagnosis of (subtypes of) diseases, improve patient selection and stratification, and detect therapeutic effects or safety concerns. This study explores the extent to which BMs are utilized in the development of treatments for neurodegenerative diseases (NDDs), as well as ...
Audrey M. M. Hermans +8 more
wiley +1 more source