Promiscuity in the enzymatic catalysis of phosphate and sulfate transfer [PDF]
The enzymes that facilitate phosphate and sulfate hydrolysis are among the most proficient natural catalysts known to date. Interestingly, a large number of these enzymes are promiscuous catalysts that exhibit both phosphatase and sulfatase activities in
Duarte, Fernanda+2 more
core +3 more sources
Arylsulfatase K, a Novel Lysosomal Sulfatase [PDF]
The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation.
Wiegmann, Elena+5 more
openaire +2 more sources
Abstract INTRODUCTION Biomarkers (BMs) are valuable tools to facilitate early diagnosis of (subtypes of) diseases, improve patient selection and stratification, and detect therapeutic effects or safety concerns. This study explores the extent to which BMs are utilized in the development of treatments for neurodegenerative diseases (NDDs), as well as ...
Audrey M. M. Hermans+8 more
wiley +1 more source
Arylsulfatase activity in marine polychaetes [PDF]
Marine polychaetes, collected from the Vellar Estuary exhibited arylsulfatase activity. Lumbriconeries sp. Polydora sp. Monojis sp. and Heteromastus sp. were selected for this study. Of these, Heteromastus sp. showed maximum enzymatic activity and it has
Dhevendaran, K.
core
Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase from Methanococcus jannaschii in Complex with Divalent Metal Ions and the Substrate Ribulose 5-Phosphate: implications for the catalytic mechanism [PDF]
Skeletal rearrangements of carbohydrates are crucial for many biosynthetic pathways. In riboflavin biosynthesis ribulose 5-phosphate is converted into 3,4-dihydroxy-2-butanone 4-phosphate while its C4 atom is released as formate in a sequence of metal ...
Bacher, Adelbert+5 more
core
Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine [PDF]
Background: The upper gastrointestinal tract plays a prominent role in human physiology as the primary site for enzymatic digestion and nutrient absorption, immune sampling, and drug uptake.
Bogatyrev, Said R.+2 more
core +1 more source
The formation of biofilms occurs due to a group of bacteria gathering together. The increasing of cell density will stimulate chemical signals for bacteria to communicate through quorum sensing system. Quorum sensing plays a role for competition, virulence, resistance, and pathogenesis. Quorum sensing produces signaling response called as autoinducers.
Salsabila Aqila Putri+4 more
wiley +1 more source
Impact of farm management on the diversity of desulfonation genes and 16S rRNA genes in wheat rhizospheres [PDF]
Worldwide the resources for mineral fertiliser are diminishing. Growth of healthy, high-yielding crop plants requires a stable input not only of nitrogen and phosphorus, but also of sulfur (S).
Guldner, Mirja Elisabeth
core
Hair follicle sulfotransferase activity and effectiveness of oral minoxidil in androgenetic alopecia
Abstract Background Androgenetic alopecia (AGA) is common. While topical minoxidil remains the only FDA‐approved therapeutic for AGA, its efficacy is limited in stimulating clinically significant hair regrowth over the longer term. Oral minoxidil, which is used off‐label, is a promising alternative; however, its effectiveness and underlying mechanisms ...
Juan Jimenez‐Cauhe+14 more
wiley +1 more source
Neuronal ceroid lipofuscinosis in American Staffordshire Terriers [PDF]
Neuronal ceroid lipofuscinoses (NCLs) represent a group of inherited progressive encephalopathies characterized by progressive loss of vision, mental or motor deterioration, epileptic seizures and premature death.
ABITBOL, Marie
core +1 more source