Results 51 to 60 of about 1,001 (167)

Promiscuity in the enzymatic catalysis of phosphate and sulfate transfer [PDF]

open access: yes, 2016
The enzymes that facilitate phosphate and sulfate hydrolysis are among the most proficient natural catalysts known to date. Interestingly, a large number of these enzymes are promiscuous catalysts that exhibit both phosphatase and sulfatase activities in
Duarte, Fernanda   +2 more
core   +3 more sources

Arylsulfatase K, a Novel Lysosomal Sulfatase [PDF]

open access: yesJournal of Biological Chemistry, 2013
The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation.
Wiegmann, Elena   +5 more
openaire   +2 more sources

Biomarkers for neurodegenerative diseases in regulatory decision‐making by the European Medicines Agency

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.
Abstract INTRODUCTION Biomarkers (BMs) are valuable tools to facilitate early diagnosis of (subtypes of) diseases, improve patient selection and stratification, and detect therapeutic effects or safety concerns. This study explores the extent to which BMs are utilized in the development of treatments for neurodegenerative diseases (NDDs), as well as ...
Audrey M. M. Hermans   +8 more
wiley   +1 more source

Arylsulfatase activity in marine polychaetes [PDF]

open access: yes, 1984
Marine polychaetes, collected from the Vellar Estuary exhibited arylsulfatase activity. Lumbriconeries sp. Polydora sp. Monojis sp. and Heteromastus sp. were selected for this study. Of these, Heteromastus sp. showed maximum enzymatic activity and it has
Dhevendaran, K.
core  

Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase from Methanococcus jannaschii in Complex with Divalent Metal Ions and the Substrate Ribulose 5-Phosphate: implications for the catalytic mechanism [PDF]

open access: yes, 2003
Skeletal rearrangements of carbohydrates are crucial for many biosynthetic pathways. In riboflavin biosynthesis ribulose 5-phosphate is converted into 3,4-dihydroxy-2-butanone 4-phosphate while its C4 atom is released as formate in a sequence of metal ...
Bacher, Adelbert   +5 more
core  

Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine [PDF]

open access: yes, 2019
Background: The upper gastrointestinal tract plays a prominent role in human physiology as the primary site for enzymatic digestion and nutrient absorption, immune sampling, and drug uptake.
Bogatyrev, Said R.   +2 more
core   +1 more source

The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review

open access: yesJournal of Chemistry, Volume 2025, Issue 1, 2025.
The formation of biofilms occurs due to a group of bacteria gathering together. The increasing of cell density will stimulate chemical signals for bacteria to communicate through quorum sensing system. Quorum sensing plays a role for competition, virulence, resistance, and pathogenesis. Quorum sensing produces signaling response called as autoinducers.
Salsabila Aqila Putri   +4 more
wiley   +1 more source

Impact of farm management on the diversity of desulfonation genes and 16S rRNA genes in wheat rhizospheres [PDF]

open access: yes, 2015
Worldwide the resources for mineral fertiliser are diminishing. Growth of healthy, high-yielding crop plants requires a stable input not only of nitrogen and phosphorus, but also of sulfur (S).
Guldner, Mirja Elisabeth
core  

Hair follicle sulfotransferase activity and effectiveness of oral minoxidil in androgenetic alopecia

open access: yesJournal of Cosmetic Dermatology, Volume 23, Issue 11, Page 3767-3773, November 2024.
Abstract Background Androgenetic alopecia (AGA) is common. While topical minoxidil remains the only FDA‐approved therapeutic for AGA, its efficacy is limited in stimulating clinically significant hair regrowth over the longer term. Oral minoxidil, which is used off‐label, is a promising alternative; however, its effectiveness and underlying mechanisms ...
Juan Jimenez‐Cauhe   +14 more
wiley   +1 more source

Neuronal ceroid lipofuscinosis in American Staffordshire Terriers [PDF]

open access: yes, 2011
Neuronal ceroid lipofuscinoses (NCLs) represent a group of inherited progressive encephalopathies characterized by progressive loss of vision, mental or motor deterioration, epileptic seizures and premature death.
ABITBOL, Marie
core   +1 more source

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