Results 61 to 70 of about 2,405 (204)

Activation Energy of Organic Matter Decomposition in Soil and Consequences of Global Warming

Global Change Biology, Volume 31, Issue 9, September 2025.
Activation energy (Ea) is the minimum energy necessary for (bio)chemical reactions defining reaction rates, e.g., organic matter transformations in soil. Based on the Ea database of enzyme activities, CO2 production, heat release during soil incubation, and thermal oxidation of soil organic matter, we assess the Ea of biotic and abiotic transformation ...
Ekaterina Filimonenko, Yakov Kuzyakov
wiley   +1 more source

UHPLC‐QTOFMS Urine Drug Screening With Dilute‐and‐Shoot Sample Preparation and Vacuum‐Insulated Probe‐Heated Electrospray Ionization

Drug Testing and Analysis, Volume 17, Issue 8, Page 1208-1218, August 2025.
The new ionization technique, vacuum‐insulated probe‐heated electrospray, allows for a simple dilute‐and‐shoot sample preparation to be used with liquid chromatography time‐of‐flight mass spectrometry in urine drug screening. Comparison with a method relying on solid‐phase extraction and conventional electrospray ionization shows improved performance ...
Mira Sundström, Pirkko Kriikku, Ilkka Ojanperä, Carsten Baessmann, Anna Pelander   +4 more
wiley   +1 more source

Characterizing Diagnostic Delays in Metachromatic Leukodystrophy: A Real‐World Data Approach

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Neurodegeneration in metachromatic leukodystrophy (MLD) may be preceded by systemic complications. Characterization of these features is critical to define barriers to early diagnosis and treatment eligibility for gene therapy. We utilized medical billing (claims) datasets and a natural history study to capture pre‐diagnosis MLD‐related events.
Ali Mohajer, Anjana Sevagamoorthy, Karen Bean, Sylvia Mutua, Francis Pang, Laura Ann Adang   +5 more
wiley   +1 more source

Screening for Life: Perspectives From Adult Metabolic Specialists on Newborn Screening for Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT The number of inherited metabolic diseases (IMDs) in newborn screening (NBS) programs has increased significantly in the past decades. For some of the IMDs included in NBS (e.g., tyrosinemia type I), there are clear and substantial health benefits of NBS, while for others (e.g., very long chain acyl CoA dehydrogenase deficiency and 3 ...
Mirjam Langeveld, Sandra Sirrs, Daphne H. Schoenmakers, Timothy Fazio, Melanie M. van der Klauw, Francois Maillot, Reena Sharma, Christel Tran, Athanasia Ziagaki, Fanny Mochel   +9 more
wiley   +1 more source

Induced Pluripotent Stem Cells for the Treatment of Lysosomal Storage Disorders

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Lysosomal disorders (LSDs) are a group of rare metabolic disorders, with an overall incidence of 1:4800 to 1:8000 live births. LSDs are primarily caused by dysfunctional lysosomal enzymes, which typically lead to the progressive accumulation of substrates within cellular lysosomes.
Maryann Lorino, Bei Qiu, Brian Bigger
wiley   +1 more source

Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD? [PDF]

, 2007
BACKGROUND: The dopamine-derived tetrahydroisoquinolines (TIQ) synthesized endogeneously from aldehydes and catecholamines have shown to modulate neurotransmission, central metabolism and motor activity.
Andreas Moser, Andreas Moser, Aribert Rothenberger, Franz Riederer, Manfred Gerlach, Regina Hünnerkopf, Susanne Walitza, Veit Roessner   +7 more
core   +4 more sources

Soil enzyme activities and health indicator characteristics in furrow‐irrigated and flooded rice production systems

Agrosystems, Geosciences &Environment, Volume 8, Issue 2, June 2025.
Abstract Conventional delayed‐flood rice (Oryza sativa L.; DFR) cultivation in United States faces increasing challenges such as nutrient losses, water scarcity, and greenhouse gas emissions. Alternative furrow‐irrigated rice (FIR) cultivation is gaining interest for its water use efficiency and production flexibility.
Aziz Ahmed, Jim J. Wang, Manoch Kongchum, Dustin L. Harrell, Nutifafa Adotey, Md Ali Haider, Lewis Gaston, Changyoon Jeong   +7 more
wiley   +1 more source

Promiscuity in the enzymatic catalysis of phosphate and sulfate transfer [PDF]

, 2016
The enzymes that facilitate phosphate and sulfate hydrolysis are among the most proficient natural catalysts known to date. Interestingly, a large number of these enzymes are promiscuous catalysts that exhibit both phosphatase and sulfatase activities in
Duarte, Fernanda, Kamerlin, SCL, Pabis, A   +2 more
core   +3 more sources

Revolution of AAV in Drug Discovery: From Delivery System to Clinical Application

Journal of Medical Virology, Volume 97, Issue 6, June 2025.
ABSTRACT Adeno‐associated virus (AAV) is a non‐enveloped DNA virus infecting a wide variety of species, tissues, and cell types, which is recognized as a safe and effective method for delivering therapeutic transgenes. AAV vector is the most popular viral gene delivery system in clinical delivery systems with unique and multiple advantages, such as ...
Ling Yin, Hongliang He, Hongliang Zhang, Yuhua Shang, Chengbo Fu, Songquan Wu, Tengchuan Jin   +6 more
wiley   +1 more source

Mammalian sulfo-conjugate metabolism [PDF]

, 1987
Sulfoconjugates occur ubiquitously as sulfopolysaccharides, sulfolipids and sulfoproteins. A variety of sulfotransferases catalyze the sulfation process with 3'- phosphoadenosine 5'-phosphosulfate as the sulfate donor.
Balasubramanian, A. S., Mathew, Joy
core