Results 81 to 90 of about 405,866 (284)

A common variant associated with dyslexia reduces expression of the KIAA0319 gene [PDF]

, 2013
This work was supported by the Wellcome Trust (MYD, SP, TSS, JCK, RWM, PC, SB, and APM), the Intramural Research Programs of the National Human Genome Research Institute (MYD and EDG) and National Cancer Institute (MPO), and the NIH/Ox-Cam Graduate ...
Beck, Stephan, Coggill, Penny, Dennis, Megan Y., Green, Eric D., Knight, Julian C., Monaco, Anthony P., Paracchini, Silvia, Prokunina-Olsson, Ludmila, Scerri, Thomas S., Wade-Martins, Richard   +9 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

27-gauge microincision vitrectomy surgery-assisted scleral fixation of intraocular lens: An anterior segment optical coherence tomography-guided study

Indian Journal of Ophthalmology
Purpose: To evaluate the outcomes of 27-gauge (27G) microincision vitrectomy surgery (MIVS)-assisted scleral fixation of intraocular lenses (SFIOLs) using anterior segment optical coherence tomography (AS-OCT).
Ashish Markan, Manasi Tripathi, Shivani Chhabra, Vipin Rana   +3 more
doaj   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]

, 2011
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Alexander Thompson, Belotti D, Buske C, Deschamps J, Edwina Dobbin, Glenda J. Dickson, Helen Wheadon, Joanne M. Ramsey, Lawrence HJ, Pamela M. Corrigan, Robin W. Freeburn   +10 more
core   +1 more source

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Effect of Light Conditions and Accommodation on Implantable Phakic Contact Lens Vault by Anterior Segment Optical Coherence Tomography

Clinical Ophthalmology, 2022
Mohamed Salah El-Din Mahmoud, Ahmed Shawkat AbdelHalim, Hosny Ahmed Zein Ophthalmology Department, Faculty of Medicine, Minia University, Minia, EgyptCorrespondence: Mohamed Salah El-Din Mahmoud, Ophthalmology Department, Faculty of Medicine, Minia ...
Mahmoud MSE, AbdelHalim AS, Zein HA
doaj  

A genetic algorithm based approach to fiber design for high coherence and large bandwidth supercontinuum generation [PDF]

, 2009
We present a new approach to the design of optical microstructured fibers that have group velocity dispersion (GVD) and effective nonlinear coefficient (gamma ) tailored for supercontinuum (SC) generation.
Alfano, Alfano, Domachuk, Dudley, Dudley, Dudley, Fercher, Ferrando, Gross, Holzwarth, Hult, Kaasalainen, Kano, Kerrinckx, Kim, Leong, Lorenc, Miret, Monro, Nishizawa, O’Donnell, Pestov, Price, Schenkel, Shahraam Afshar V., Silvestre, Silvestre, Solli, Stolen, Tanya M. Monro, Travers, Turner, Vogel, Washburn, Washburn, Wen Qi Zhang, Xia, Zhang, Zhu   +38 more
core   +2 more sources

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source