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Predictive signatures of immune response to vaccination and implications of the immune setpoint remodeling. [PDF]

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Ramos I.
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Safety and Immunogenicity of a monovalent inactivated influenza A/H5N8 virus vaccine given with and without AS03 or MF59 adjuvants in healthy adults.

Clinical Infectious Diseases, 2023
BACKGROUND Avian influenza A/H5N8 virus infections have been circulating widely in wild and domestic bird populations with transmission to a few human poultry workers.
P. Winokur, T. Hegmann, W. Keitel, D. Bernstein, S. Frey, C. Bryant   +5 more
semanticscholar   +1 more source

Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine

Vaccine, 2011
Intramuscular vaccination may lead to loss of subcutaneous fat resulting in skin depression at the site of injection. We report for the first time a delayed lipoatrophy after with AS03-adjuvanted influenza A (H1N1) 2009 vaccine. Inadequate administration into the adipose tissue may be causative.
Emilie, Javelle, Benjamin, Soulier, Christian, Brosset, Solène, Lorcy, Fabrice, Simon   +4 more
openaire   +2 more sources

Non‐clinical safety and biodistribution of AS03‐adjuvanted inactivated pandemic influenza vaccines

Journal of Applied Toxicology, 2015
AbstractPandemic‐influenza vaccines containing split‐inactivated‐virus antigen have been formulated with the immunostimulatory Adjuvant System AS03 to enhance the antigen immunogenicity and reduce antigen content per dose. AS03 is an oil‐in‐water emulsion containing α‐tocopherol, squalene and polysorbate 80.
Segal, L., Wouters, S., Morelle, D., Gautier, G., Gal, J. Le, Martin, T., Kuper, F., Destexhe, E., Didierlaurent, A.M., Garçon, N.   +9 more
openaire   +3 more sources

Responses of Solid Organ Transplant Recipients to the As03-Adjuvanted Pandemic Influenza Vaccine

Antiviral Therapy, 2012
Background Solid organ transplant (SOT) recipients are a priority group for influenza vaccination and strategies enhancing immunogenicity are needed. Methods We determined adverse reactions, changes in biomarkers of graft function and immune responses to two doses of the AS03-adjuvanted influenza A/09/H1N1 vaccine in 216 SOT recipients and in 138 ...
Siegrist, Claire-Anne, Ambrosioni Czyrko, Juan, Bel, Michael, Combescure, Christophe, Hadaya, Karine, Martin, Pierre-Yves, Gasche-Soccal, Paola Marina Alessandra, Berney, Thierry, Noble, Stéphane Laurent, Meier, Sara, Posfay Barbe, Klara, Grillet, Stéphane, Kaiser, Laurent, Van Delden, Christian   +13 more
openaire   +3 more sources

Immunogenicity and safety of AS03-adjuvanted H1N1 pandemic vaccines in children and adolescents

Vaccine, 2011
Vaccines with acceptable efficacy profile against the H1N1 A/California/7/2009 virus are needed for use in children. The two studies presented here evaluated the immunogenicity and the reactogenicity/safety of A/H1N1/2009 vaccines containing either 3.75 μg haemagglutinin antigen (HA) and AS03(A)-adjuvant (3.75 μg HA/AS03(A) study) (N=210 [53, 57 and ...
J, Garcia-Sicilia, P, Gillard, A, Carmona, J C, Tejedor, J, Aristegui, J M, Merino, U, Behre, A, Caplanusi, T, Vaman, I, Dieussaert   +9 more
openaire   +2 more sources

Survey about tolerance of the AS03-adjuvanted H1N1 influenza vaccine in children with rheumatic diseases

Clinical Rheumatology, 2013
The objective of this study is to evaluate complications and changes in health status (disease activity and flare) in response to the AS03-adjuvanted H1N1 vaccine in children with rheumatic diseases. We conducted a nationwide survey addressing paediatric rheumatology sites who participated in the national paediatric rheumatology database.
C, Sengler, M, Niewerth, T, Kallinich, A, Nimtz-Talaska, M, Haller, H-I, Huppertz, K, Minden   +6 more
openaire   +2 more sources

Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development

Brain, Behavior, and Immunity, 2015
Narcolepsy onset in children has been associated with the 2009 influenza A H1N1 pandemic and vaccination with Pandemrix. However it was not clearly observed with other adjuvanted pH1N1 vaccines such as Arepanrix or Focetria. Our aim was to characterize the differences between Pandemrix and Arepanrix that might explain the risk for narcolepsy after ...
Louis, Jacob, Ryan, Leib, Hanna M, Ollila, Mélodie, Bonvalet, Christopher M, Adams, Emmanuel, Mignot   +5 more
openaire   +2 more sources