Results 1 to 10 of about 163,003 (272)

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice

Nature Communications, 2022
Immune checkpoint blockade (ICB) is partially successful as a cancer therapy. Here using mouse models, the authors transcriptionally monitor responding and non-responding tumours showing that responding tumours were associated with transient IFN-β ...
Rachael M. Zemek, Wee Loong Chin, Vanessa S. Fear, Ben Wylie, Thomas H. Casey, Cath Forbes, Caitlin M. Tilsed, Louis Boon, Belinda B. Guo, Anthony Bosco, Alistair R. R. Forrest, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Timo Lassmann, W. Joost Lesterhuis   +15 more
doaj   +1 more source

Must countries shoulder the burden of mesothelioma to ban asbestos? A global assessment

BMJ Global Health, 2022
Introduction Mesothelioma is a key asbestos-related disease (ARD) but can be difficult to diagnose. Countries presumably ban asbestos to reduce future ARD burdens, but it is unknown if countries ban asbestos as a consequence of ARD burdens.
Seong-Kyu Kang, Ro-ting Lin, Sonja Klebe, Ken Takahashi, Odgerel Chimed-Ochir, Anna K Nowak, Tatsuhiko Kubo, Sugio Furuya, Emma M Rath, Yui Yumiya, Kim Brislane   +10 more
doaj   +1 more source

The analysis of novel microRNA mimic sequences in cancer cells reveals lack of specificity in stem-loop RT-qPCR-based microRNA detection

BMC Research Notes, 2017
Objective MicroRNAs are frequently downregulated in cancer, and restoring expression has tumour suppressive activity in tumour cells. Our recent phase I clinical trial investigated microRNA-based therapy in patients with malignant pleural mesothelioma ...
Patrick Winata, Marissa Williams, Eileen McGowan, Najah Nassif, Nico van Zandwijk, Glen Reid   +5 more
doaj   +1 more source

Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model

BMC Research Notes, 2020
Objective There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations.
Scott A. Fisher, Carolyn J. Peddle-McIntyre, Kimberley Burton, Robert U.  Newton, Elly Marcq, Richard A. Lake, Anna K. Nowak   +6 more
doaj   +1 more source

CDKN2A and MTAP Are Useful Biomarkers Detectable by Droplet Digital PCR in Malignant Pleural Mesothelioma: A Potential Alternative Method in Diagnosis Compared to Fluorescence In Situ Hybridisation

Frontiers in Oncology, 2020
BackgroundThe diagnosis of malignant pleural mesothelioma (MPM) can be difficult, in part due to the difficulty in distinguishing between MPM and reactive mesothelial hyperplasia (RMH).
Yuen Yee Cheng, Man Lee Yuen, Emma M. Rath, Emma M. Rath, Ben Johnson, Ling Zhuang, Ta-kun Yu, Vesna Aleksova, Anthony Linton, Anthony Linton, Steven Kao, Steven Kao, Candice Julie Clarke, Brian C. McCaughan, Ken Takahashi, Kenneth Lee, Kenneth Lee, Kenneth Lee   +17 more
doaj   +1 more source

Cell-free microRNAs: potential biomarkers in need of standardized reporting

Frontiers in Genetics, 2013
MicroRNAs are abundantly present and surprisingly stable in multiple biological fluids. These findings have been followed by numerous of reports revealing the clinical potential of using microRNA levels in body fluids as a biomarker of disease. Despite a
Michaela B Kirschner, Nico evan Zandwijk, Glen eReid   +2 more
doaj   +1 more source

MicroRNA gene expression signatures in long-surviving malignant pleural mesothelioma patients

Genomics Data, 2016
Malignant pleural mesothelioma (MPM) is a tumor originating in the mesothelium, the membrane lining the thoracic cavities, and is induced by exposure to asbestos. Australia suffers one of the world's highest rates of MPM and the incidence is yet to peak.
Ruby C.Y. Lin, Michaela B. Kirschner, Yuen Yee Cheng, Nico van Zandwijk, Glen Reid   +4 more
doaj   +1 more source

Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations

Frontiers in Immunology, 2022
Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses
Nicola Principe, Nicola Principe, Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Caitlin M. Tilsed, Caitlin M. Tilsed, Scott A. Fisher, Scott A. Fisher, Scott A. Fisher, Louis Boon, Ian M. Dick, Ian M. Dick, Wee Loong Chin, Wee Loong Chin, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Anna K. Nowak, Anna K. Nowak, Richard A. Lake, Richard A. Lake, Richard A. Lake, Jonathan Chee, Jonathan Chee, Jonathan Chee, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Willem Joost Lesterhuis   +30 more
doaj   +1 more source

Mongolia: Failure of Total Banning of Asbestos

Annals of Global Health, 2023
The primary uses of asbestos in Mongolia are in thermal power plants, construction and at railway companies. There is, however, limited data on both asbestos consumption and asbestos related disease (ARD) in Mongolia.
Naransukh Damiran, Arthur L. Frank
doaj   +1 more source

The Brazilian Method for the Determination of Airborne Inorganic Fibres Concentration (Including Asbestos Fibres) – Membrane Filter Method

KONA Powder and Particle Journal, 2014
This paper reports a historical description of the "Brazilian Method For The Determination Of Airborne Inorganic Fibres Concentration (including asbestos fibres) -Membrane Filter Method" since the creation ...
Rosemary S. Ishii Zamataro, Wagner José Meirelles   +1 more
doaj   +1 more source