Results 11 to 20 of about 12,650 (168)
Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action
Frontiers in Oncology, 2022 Chemotherapy has historically been the mainstay of cancer treatment, but our understanding of what drives a successful therapeutic response remains limited.
Caitlin M. Tilsed +11 more
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Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
Frontiers in Oncology, 2021 The success of immunotherapy that targets inhibitory T cell receptors for the treatment of multiple cancers has seen the anti-tumor immune response re-emerge as a promising biomarker of response to therapy. Longitudinal characterization of T cells in the
Nicola Principe +12 more
doaj +1 more source
Immune marker expression of irradiated mesothelioma cell lines
Frontiers in Oncology, 2022 BackgroundThough immune checkpoint inhibition has recently shown encouraging clinical efficacy in mesothelioma, most patients do not respond. Combining immune checkpoint inhibition with radiotherapy presents an attractive option for improving treatment ...
Faith Chang +16 more
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Frontiers in Oncology, 2021 Thoracic cancers pose a significant global health burden. Immune checkpoint blockade therapies have improved treatment outcomes, but durable responses remain limited. Understanding how the host immune system interacts with a developing tumor is essential
Kiarash Behrouzfar +9 more
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BMC Cancer, 2017 Background Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully determined in phase I studies.
Wayne J. Aston +5 more
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Frontiers in Oncology, 2022 With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the
Caitlin M. Tilsed +20 more
doaj +1 more source
Enhancing the efficacy of immunotherapy using radiotherapy
Clinical & Translational Immunology, 2020 Recent clinical breakthroughs in cancer immunotherapy, especially with immune checkpoint blockade, offer great hope for cancer sufferers – and have greatly changed the landscape of cancer treatment.
Synat Keam +4 more
doaj +1 more source
Frontiers in Immunology, 2020 Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that ...
Nicola Principe +29 more
doaj +1 more source
Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses
Frontiers in Immunology, 2020 Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond.
Joel Kidman +15 more
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Advances in Radiation Oncology, 2022 Purpose: To characterize the cellular responses of murine and human mesothelioma cell lines to different doses of photon radiation with a long-term aim of optimizing a clinically relevant in vivo model in which to study the interaction of radiation ...
Synat Keam +6 more
doaj +1 more source