Results 31 to 40 of about 41,943 (257)

Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy

Frontiers in Oncology, 2022
With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the
Caitlin M. Tilsed, Caitlin M. Tilsed, Thomas H. Casey, Thomas H. Casey, Emma de Jong, Anthony Bosco, Rachael M. Zemek, Joanne Salmons, Joanne Salmons, Graeme Wan, Graeme Wan, Michael J. Millward, Michael J. Millward, Anna K. Nowak, Anna K. Nowak, Anna K. Nowak, Richard A. Lake, Richard A. Lake, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Willem Joost Lesterhuis   +20 more
doaj   +1 more source

Enhancing the efficacy of immunotherapy using radiotherapy

Clinical & Translational Immunology, 2020
Recent clinical breakthroughs in cancer immunotherapy, especially with immune checkpoint blockade, offer great hope for cancer sufferers – and have greatly changed the landscape of cancer treatment.
Synat Keam, Suki Gill, Martin A Ebert, Anna K Nowak, Alistair M Cook   +4 more
doaj   +1 more source

Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy

Frontiers in Immunology, 2020
Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that ...
Nicola Principe, Nicola Principe, Joel Kidman, Joel Kidman, Siting Goh, Caitlin M. Tilsed, Caitlin M. Tilsed, Scott A. Fisher, Scott A. Fisher, Vanessa S. Fear, Catherine A. Forbes, Rachael M. Zemek, Abha Chopra, Mark Watson, Ian M. Dick, Ian M. Dick, Louis Boon, Robert A. Holt, Richard A. Lake, Richard A. Lake, Anna K. Nowak, Anna K. Nowak, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Alison M. McDonnell, Alison M. McDonnell, Alison M. McDonnell, Jonathan Chee, Jonathan Chee   +29 more
doaj   +1 more source

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

Frontiers in Immunology, 2020
Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond.
Joel Kidman, Joel Kidman, Nicola Principe, Nicola Principe, Mark Watson, Timo Lassmann, Robert A. Holt, Anna K. Nowak, Anna K. Nowak, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Richard A. Lake, Richard A. Lake, Jonathan Chee, Jonathan Chee   +15 more
doaj   +1 more source

Effects of Photon Radiation on DNA Damage, Cell Proliferation, Cell Survival, and Apoptosis of Murine and Human Mesothelioma Cell Lines

Advances in Radiation Oncology, 2022
Purpose: To characterize the cellular responses of murine and human mesothelioma cell lines to different doses of photon radiation with a long-term aim of optimizing a clinically relevant in vivo model in which to study the interaction of radiation ...
Synat Keam, Kelly M. MacKinnon, Rebecca A. D'Alonzo, Suki Gill, MD, Martin A. Ebert, PhD, Anna K. Nowak, MD, PhD, Alistair M. Cook, PhD   +6 more
doaj   +1 more source

Differential protein folding and chemical changes in lung tissues exposed to asbestos or particulates [PDF]

, 2015
Environmental and occupational inhalants may induce a large number of pulmonary diseases, with asbestos exposure being the most risky. The mechanisms are clearly related to chemical composition and physical and surface properties of materials.
Bedolla Diana, E, Birarda, G, Borelli, Violetta, Calligaro, C, Canzonieri, V, Cotte, M, Gianoncelli, A, Hesse, B, Luisi, F, Melato, M, Pascolo, Lorella, Rizzardi, Clara, Salom\ue9, M, Vaccari, L, Zabucchi, Giuliano   +14 more
core   +1 more source

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors

BMC Research Notes, 2018
Objective Pleural effusion (PE) is a common feature of malignant pleural mesothelioma. These effusions typically contain lymphocytes and malignant cells. We postulated that the PE would be a source of lymphocytes for analysis of tumor immune milieu.
Jonathan Chee, Mark W. Watson, Abha Chopra, Bella Nguyen, Alistair M. Cook, Jenette Creaney, Willem J. Lesterhuis, Bruce W. Robinson, Y. C. Gary Lee, Anna K. Nowak, Richard A. Lake, Alison M. McDonnell   +11 more
doaj   +1 more source

Occupational characteristics of cases with asbestos-related diseases in The Netherlands [PDF]

, 2003
OBJECTIVE: To describe the occupational background of cases with an asbestos-related disease and to present overall mesothelioma risks across industries with historical exposure to asbestos. METHODS: For the period 1990-2000, cases were
Burdorf, A. (Alex), Dahhan, M., Swuste, P. (Paul)   +2 more
core   +2 more sources

A case of asbestos-related lung cancer: critical analysis and discussion of the medico-legal aspects [PDF]

GIornale Italiano di Psicologia e Medicina del Lavoro, 2021
Asbestos is a naturally occurring fibrous silicate mineral. There are six types, all of which are com- posed by long and thin fibrous crystals that can be released into the atmosphere by abrasion and other processes.
Dario MAZZARELLA, Pasquale BUONGIORNO, Pasquale VIETRI   +2 more
doaj   +1 more source

Asbestos-related pleural disease

Autopsy and Case Reports, 2013
The image shows asbestos plaques on the right parietal pleura of a 58-year-old former shipyard worker who died of acute suppurative bronchitis. He also had cor pulmonale and congestive heart failure. Histologically, pulmonary interstitial fibrosis with asbestos bodies was demonstrated. The pleural plaques consist predominantly of dense collagen.
Stephen A. Geller, Fernando Peixoto Ferraz de Campos   +1 more
openaire   +3 more sources