Results 31 to 40 of about 13,080 (176)

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, EarlyView.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy

Scientific Data
Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood.
Wee Loong Chin, Rachael M. Zemek, Caitlin M. Tilsed, Alistair R. R. Forrest, Vanessa S. Fear, Catherine Forbes, Louis Boon, Anthony Bosco, Belinda B. Guo, Michael J. Millward, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis, Timo Lassmann   +13 more
doaj   +1 more source

Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor

Molecular Oncology, 2021
Previous studies have indicated a synergistic effect between radiotherapy and immunotherapy. A better understanding of how this combination affects the immune system can help to clarify its role in the treatment of metastatic cancer.
Åsa Kristina Öjlert, Daniel Nebdal, Igor Snapkov, Vibeke Olsen, Joel Kidman, Victor Greiff, Jonathan Chee, Åslaug Helland   +7 more
doaj   +1 more source

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source

Hidden Targets in Cancer Immunotherapy: The Potential of “Dark Matter” Neoantigens

Vaccines
The development of cancer immunotherapies has transformed cancer treatment paradigms, yet durable and tumour-specific responses remain elusive for many patients.
Francois Xavier Rwandamuriye, Alec J. Redwood, Jenette Creaney, Bruce W. S. Robinson   +3 more
doaj   +1 more source

The Hidden Costs of Coffee Production in the Eastern African Value Chains

Sustainable Development, EarlyView.
ABSTRACT There is increasing recognition that significant hidden costs associated with agrifood systems are not reflected in market prices. Coffee is among the three most traded agricultural commodities in the world and supports the livelihoods of more than 30 million smallholder households.
Annet Adong, Lukas Kornher, Bezawit Beyene Chichaibelu, Aslihan Arslan   +3 more
wiley   +1 more source

Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner

BMC Cancer
Background Chemotherapy is included in treatment regimens for many solid cancers, but when administered as a single agent it is rarely curative. The addition of immune checkpoint therapy to standard chemotherapy regimens has improved response rates and ...
Caitlin M. Tilsed, M. Lizeth Orozco Morales, Rachael M. Zemek, Brianna A. Gordon, Matthew J. Piggott, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis   +8 more
doaj   +1 more source

Sustainability Assessment: The Role of Entropy‐Based Indicators for Reconnecting Human' Subjectivity and Civilization With Natural Tendency of Ecosystems

Sustainable Development, EarlyView.
ABSTRACT Sustainability represents a complex issue in which scientific knowledge inevitably coexists with the subjective perception of humans in its turn influenced by civilization, cultural but also unconscious aspects. These results emerge with evidence from a critical analysis of the main definitions of sustainability delivered by credited entities (
Francesco Di Maria, Hamid Safarzadeh
wiley   +1 more source

Neoantigen load as a predictor of relapse in early-stage NSCLC: features that agonise and antagonise prognosis

Cancer Immunology, Immunotherapy
Background Neoantigen-specific immune responses may help prevent cancer recurrence. We evaluated whether neoantigen load and/or properties could predict survival in early-stage non-small cell lung cancer (NSCLC). Methods Whole-exome sequencing (WES) data
Linda Ye, Ian Dick, Bruce W. Robinson, Jenette Creaney, Alec Redwood   +4 more
doaj   +1 more source

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

iScience, 2022
Summary: Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath.
M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis   +21 more
doaj   +1 more source