Results 51 to 60 of about 41,943 (257)

An Evaluation of Mortality Rates and Their Determinants in a Cohort of Former Asbestos Miners in South Africa

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background A causal association between occupational asbestos exposure and lung disease, including pneumoconiosis and mesothelioma, is well established. Elevated mortality among former asbestos miners is expected. However, large‐scale South African studies examining all‐cause mortality in this population are lacking.
Yumna Williams‐Mohamed, Rodney Ehrlich, Jim teWaterNaude, Shahieda Adams   +3 more
wiley   +1 more source

Hidden Targets in Cancer Immunotherapy: The Potential of “Dark Matter” Neoantigens

Vaccines
The development of cancer immunotherapies has transformed cancer treatment paradigms, yet durable and tumour-specific responses remain elusive for many patients.
Francois Xavier Rwandamuriye, Alec J. Redwood, Jenette Creaney, Bruce W. S. Robinson   +3 more
doaj   +1 more source

What Courts Can Do in the Face of the Never-Ending Asbestos Crisis [PDF]

, 2001
The purpose of this article is not to argue that claimants suffering from serious asbestos-related diseases should not be compensated. To the contrary, one of the points of this article is that absent some change in the way asbestos claims are resolved ...
Rothstein, Paul F
core   +1 more source

Civilian Occupational Exposure to Vapors, Gas, Dust, or Fumes and Respiratory Health Among United States Military Veterans

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background We investigated associations of self‐reported and job exposure matrix (JEM) assigned civilian occupational exposure to vapors, gas, dust, or fumes (VGDF) with respiratory symptoms among previously deployed US Veterans. Methods An interviewer‐administered questionnaire ascertained self‐reported civilian occupational VGDF exposure.
Sahra Mohazzab‐Hosseinian, Carrie A. Redlich, Anna M. Korpak, Andrew K. I. Timmons, Nicholas L. Smith, Karen S. Nakayama, Farrah Kheradmand, Vincent S. Fan, Michael Jerrett, Philippe R. Montgrain, Christine H. Wendt, Ware G. Kuschner, Emily S. Wan, Eric Garshick, Paul D. Blanc   +14 more
wiley   +1 more source

Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner

BMC Cancer
Background Chemotherapy is included in treatment regimens for many solid cancers, but when administered as a single agent it is rarely curative. The addition of immune checkpoint therapy to standard chemotherapy regimens has improved response rates and ...
Caitlin M. Tilsed, M. Lizeth Orozco Morales, Rachael M. Zemek, Brianna A. Gordon, Matthew J. Piggott, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis   +8 more
doaj   +1 more source

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

iScience, 2022
Summary: Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath.
M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis   +21 more
doaj   +1 more source

Respirable Dust Exposure in Western Australian Mining: Trends, Variability, and Implications for Occupational Health

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Mining workers are exposed to a range of respiratory hazards, including respirable dust. While exposure to respirable crystalline silica in the mining industry has been found to be common, less is known about trends in measured levels of exposure to respirable dust overall.
Renee N. Carey, Susan Peters, Nicholas de Klerk, Fraser Brims, Peter Franklin   +4 more
wiley   +1 more source

Neoantigen load as a predictor of relapse in early-stage NSCLC: features that agonise and antagonise prognosis

Cancer Immunology, Immunotherapy
Background Neoantigen-specific immune responses may help prevent cancer recurrence. We evaluated whether neoantigen load and/or properties could predict survival in early-stage non-small cell lung cancer (NSCLC). Methods Whole-exome sequencing (WES) data
Linda Ye, Ian Dick, Bruce W. Robinson, Jenette Creaney, Alec Redwood   +4 more
doaj   +1 more source

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, EarlyView.
What's New? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

Ongoing downplaying of the carcinogenicity of chrysotile asbestos by vested interests

Journal of Occupational Medicine and Toxicology, 2021
Industries that mine, manufacture and sell asbestos or asbestos-containing products have a long tradition of promoting the use of asbestos, while placing the burden of economic and health costs on workers and society.
Xaver Baur, Arthur L. Frank
doaj   +1 more source