Results 61 to 70 of about 13,080 (176)
Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade
Journal for ImmunoTherapy of CancerBackground Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death protein/ligand 1 (PD-1/PD-L1) are approved for treatment of multiple cancer types.Elly Marcq, Anna K Nowak, W Joost Lesterhuis, Caitlin M Tilsed, Nicola Principe, Amber-Lee Phung, Kofi L P Stevens, Omar Elaskalani, Ben Wylie, Fezaan Sheikh, M Lizeth Orozco Morales, Joel Kidman, Scott A Fisher, Alison M McDonnell, Jonathan Chee +14 moredoaj +1 more sourceSIRT Family: Biological Functions and Therapeutic Targets
MedComm, Volume 7, Issue 8, August 2026.SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong +9 morewiley +1 more sourceThe MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop
Frontiers in ToxicologyObjectives: This study combines two innovative mouse models in a major gene discovery project to assess the influence of host genetics on asbestos related disease (ARD).Scott A. Fisher, Scott A. Fisher, Scott A. Fisher, Kimberley Patrick, Kimberley Patrick, Kimberley Patrick, Tracy Hoang, Tracy Hoang, Elly Marcq, Elly Marcq, Elly Marcq, Kiarash Behrouzfar, Kiarash Behrouzfar, Kiarash Behrouzfar, Sylvia Young, Timothy J. Miller, Bruce W. S. Robinson, Bruce W. S. Robinson, Bruce W. S. Robinson, Raphael Bueno, Anna K. Nowak, Anna K. Nowak, Anna K. Nowak, W. Joost Lesterhuis, Grant Morahan, Richard A. Lake, Richard A. Lake +26 moredoaj +1 more sourceProspective study of asbestos-related diseases incidence cases in primary health care in an area of Barcelona province
BMC Public Health, 2010 Background Asbestos related diseases include a number of conditions due to inhalation of asbestos fibres at work, at home or in the environment, such as pleural mesothelioma, asbestosis and calcified pleural plaques.Orriols Ramon, Gallego Miguel, Cantarell Gloria, Krier Ilona, García-Allas Isabel, Martínez-Artés Xavier, Tarrés Josep, Abós-Herràndiz Rafael, Rosell-Murphy Magdalena, Albertí Constança +9 moredoaj +1 more sourceInsights Into Genomic Drivers, Transcriptomic Heterogeneity, and Therapeutic Vulnerabilities From Novel Mesothelioma Cell Lines
Thoracic Cancer, Volume 17, Issue 15, August 2026.Three novel malignant pleural mesothelioma (MPM) cell lines (PUMC‐MESO1, PUMC‐MESO3, and PUMC‐MESO4) were established from patient‐derived pleural effusions. All three cell lines expressed mesothelioma markers (calretinin, WT1, and D2‐40) and showed BAP1 loss of expression.Yani Wu, Fang Cao, Jiayin Dai, Zhenli Yang, Yanli Zhu, Dongmei Lin, Xiaocui Bian, Yuqin Liu +7 morewiley +1 more sourceAssessment of a feed additive consisting of montmorillonite‐illite mixed layer clay mineral (1g557) for all animal species for the renewal of its authorisation (FIM Biotech GmbH)
EFSA Journal, Volume 24, Issue 8, August 2026.Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the renewal of montmorillonite‐illite mixed layer clay mineral as a technological feed additive for all animal species. The applicant has provided evidence that the additive currently on the market complies with the existing conditions of ...EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Jaume Galobart, Maria Vittoria Vettori, Orsolya Holczknecht, Fabiola Pizzo, Piera Valeri +21 morewiley +1 more sourceAsbestos and Asbestos-related Diseases in Vietnam: In reference to the International Labor Organization/World Health Organization National Asbestos Profile
Safety and Health at Work, 2013 This paper describes progress on formulating a national asbestos profile for the country of Vietnam. The Center of Asbestos Resource, Vietnam, formulated a National Profile on Asbestos-related Occupational Health, with due reference to the International ...Van Hai Pham, Thi Ngoc Lan Tran, Giang Vinh Le, Mehrnoosh Movahed, Ying Jiang, Nguyen Ha Pham, Hisashi Ogawa, Ken Takahashi +7 moredoaj +1 more sourceULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance
International Journal of Cancer, Volume 159, Issue 2, Page 410-422, 15 July 2026.What's new?
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz +54 morewiley +1 more sourceImmune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes
OncoImmunologyImmune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response.Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee +21 moredoaj +1 more source
