Results 21 to 30 of about 12,650 (168)

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors

BMC Research Notes, 2018
Objective Pleural effusion (PE) is a common feature of malignant pleural mesothelioma. These effusions typically contain lymphocytes and malignant cells. We postulated that the PE would be a source of lymphocytes for analysis of tumor immune milieu.
Jonathan Chee, Mark W. Watson, Abha Chopra, Bella Nguyen, Alistair M. Cook, Jenette Creaney, Willem J. Lesterhuis, Bruce W. Robinson, Y. C. Gary Lee, Anna K. Nowak, Richard A. Lake, Alison M. McDonnell   +11 more
doaj   +1 more source

A case of asbestos-related lung cancer: critical analysis and discussion of the medico-legal aspects [PDF]

GIornale Italiano di Psicologia e Medicina del Lavoro, 2021
Asbestos is a naturally occurring fibrous silicate mineral. There are six types, all of which are com- posed by long and thin fibrous crystals that can be released into the atmosphere by abrasion and other processes.
Dario MAZZARELLA, Pasquale BUONGIORNO, Pasquale VIETRI   +2 more
doaj   +1 more source

Asbestos-related pleural disease

Autopsy and Case Reports, 2013
The image shows asbestos plaques on the right parietal pleura of a 58-year-old former shipyard worker who died of acute suppurative bronchitis. He also had cor pulmonale and congestive heart failure. Histologically, pulmonary interstitial fibrosis with asbestos bodies was demonstrated. The pleural plaques consist predominantly of dense collagen.
Stephen A. Geller, Fernando Peixoto Ferraz de Campos   +1 more
openaire   +3 more sources

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy

Frontiers in Immunology, 2020
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, providing remarkable clinical responses in some patients. However, the majority of patients do not respond.
Rachael M. Zemek, Wee Loong Chin, Wee Loong Chin, Wee Loong Chin, Anna K. Nowak, Anna K. Nowak, Anna K. Nowak, Michael J. Millward, Michael J. Millward, Richard A. Lake, Richard A. Lake, W. Joost Lesterhuis, W. Joost Lesterhuis, W. Joost Lesterhuis   +13 more
doaj   +1 more source

The role and therapeutic implications of T cells in cancer of the lung

Clinical & Translational Immunology, 2019
Lung cancer remains the leading cause of cancer‐related death worldwide. The disease is classified into two major subtypes, small‐cell lung cancer (SCLC) and the more prevalent non‐small‐cell lung cancer (NSCLC).
Samuel C Neeve, Bruce WS Robinson, Vanessa S Fear   +2 more
doaj   +1 more source

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

iScience, 2022
Summary: Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath.
M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis   +21 more
doaj   +1 more source

Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor

Molecular Oncology, 2021
Previous studies have indicated a synergistic effect between radiotherapy and immunotherapy. A better understanding of how this combination affects the immune system can help to clarify its role in the treatment of metastatic cancer.
Åsa Kristina Öjlert, Daniel Nebdal, Igor Snapkov, Vibeke Olsen, Joel Kidman, Victor Greiff, Jonathan Chee, Åslaug Helland   +7 more
doaj   +1 more source

Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy

Scientific Data
Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood.
Wee Loong Chin, Rachael M. Zemek, Caitlin M. Tilsed, Alistair R. R. Forrest, Vanessa S. Fear, Catherine Forbes, Louis Boon, Anthony Bosco, Belinda B. Guo, Michael J. Millward, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis, Timo Lassmann   +13 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Hidden Targets in Cancer Immunotherapy: The Potential of “Dark Matter” Neoantigens

Vaccines
The development of cancer immunotherapies has transformed cancer treatment paradigms, yet durable and tumour-specific responses remain elusive for many patients.
Francois Xavier Rwandamuriye, Alec J. Redwood, Jenette Creaney, Bruce W. S. Robinson   +3 more
doaj   +1 more source