Results 21 to 30 of about 194,700 (326)

How asbestos and other fibers cause mesothelioma

Translational Lung Cancer Research, 2020
Mesothelioma has long been associated with the exposure to asbestos, which was largely used in manufacturing activities. Toxicology studies in vitro and in vivo demonstrated that asbestos fibers were carcinogenic, and epidemiology studies revealed that ...
G. Gaudino, Jiaming Xue, Haining Yang
semanticscholar   +1 more source

Asbestos - Cement Roofing Identification Using Remote Sensing and Convolutional Neural Networks (CNNs)

Remote Sensing, 2020
Due to the pathogenic nature of asbestos, a statutory ban on asbestos-containing products has been in place in Poland since 1997. In order to protect human health and the environment, it is crucial to estimate the quantity of asbestos–cement products in ...
M. Krówczyńska, Edwin Raczko, Natalia Staniszewska, Ewa Wilk   +3 more
semanticscholar   +1 more source

Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model

BMC Research Notes, 2020
Objective There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations.
Scott A. Fisher, Carolyn J. Peddle-McIntyre, Kimberley Burton, Robert U.  Newton, Elly Marcq, Richard A. Lake, Anna K. Nowak   +6 more
doaj   +1 more source

The analysis of novel microRNA mimic sequences in cancer cells reveals lack of specificity in stem-loop RT-qPCR-based microRNA detection

BMC Research Notes, 2017
Objective MicroRNAs are frequently downregulated in cancer, and restoring expression has tumour suppressive activity in tumour cells. Our recent phase I clinical trial investigated microRNA-based therapy in patients with malignant pleural mesothelioma ...
Patrick Winata, Marissa Williams, Eileen McGowan, Najah Nassif, Nico van Zandwijk, Glen Reid   +5 more
doaj   +1 more source

Asbestos-related cancers: the ‘Hidden Killer’ remains a global threat

Expert Review of Anticancer Therapy, 2020
Introduction: Asbestos, the most frequent cause of occupational cancer, continues to be consumed on a massive scale, with millions of people exposed on a daily basis.
N. van Zandwijk, G. Reid, A. Frank
semanticscholar   +1 more source

CDKN2A and MTAP Are Useful Biomarkers Detectable by Droplet Digital PCR in Malignant Pleural Mesothelioma: A Potential Alternative Method in Diagnosis Compared to Fluorescence In Situ Hybridisation

Frontiers in Oncology, 2020
BackgroundThe diagnosis of malignant pleural mesothelioma (MPM) can be difficult, in part due to the difficulty in distinguishing between MPM and reactive mesothelial hyperplasia (RMH).
Yuen Yee Cheng, Man Lee Yuen, Emma M. Rath, Emma M. Rath, Ben Johnson, Ling Zhuang, Ta-kun Yu, Vesna Aleksova, Anthony Linton, Anthony Linton, Steven Kao, Steven Kao, Candice Julie Clarke, Brian C. McCaughan, Ken Takahashi, Kenneth Lee, Kenneth Lee, Kenneth Lee   +17 more
doaj   +1 more source

Global use of asbestos - legitimate and illegitimate issues

Journal of occupational medicine and toxicology, 2020
Background Exposure to asbestos causes non-malignant and malignant diseases including asbestosis, lung cancer, and mesothelioma. The modern history of such diseases goes back more than a century.
A. Frank
semanticscholar   +1 more source

Cell-free microRNAs: potential biomarkers in need of standardized reporting

Frontiers in Genetics, 2013
MicroRNAs are abundantly present and surprisingly stable in multiple biological fluids. These findings have been followed by numerous of reports revealing the clinical potential of using microRNA levels in body fluids as a biomarker of disease. Despite a
Michaela B Kirschner, Nico evan Zandwijk, Glen eReid   +2 more
doaj   +1 more source

MicroRNA gene expression signatures in long-surviving malignant pleural mesothelioma patients

Genomics Data, 2016
Malignant pleural mesothelioma (MPM) is a tumor originating in the mesothelium, the membrane lining the thoracic cavities, and is induced by exposure to asbestos. Australia suffers one of the world's highest rates of MPM and the incidence is yet to peak.
Ruby C.Y. Lin, Michaela B. Kirschner, Yuen Yee Cheng, Nico van Zandwijk, Glen Reid   +4 more
doaj   +1 more source

Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations

Frontiers in Immunology, 2022
Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses
Nicola Principe, Nicola Principe, Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Caitlin M. Tilsed, Caitlin M. Tilsed, Scott A. Fisher, Scott A. Fisher, Scott A. Fisher, Louis Boon, Ian M. Dick, Ian M. Dick, Wee Loong Chin, Wee Loong Chin, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Anna K. Nowak, Anna K. Nowak, Richard A. Lake, Richard A. Lake, Richard A. Lake, Jonathan Chee, Jonathan Chee, Jonathan Chee, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Willem Joost Lesterhuis, Willem Joost Lesterhuis   +30 more
doaj   +1 more source