Results 141 to 150 of about 513,389 (355)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Kerouac Ascending Memorabilia of the Decade of On the Road

open access: yes
Kerouac Ascending: Memorabilia of the Decade of ON THE ROAD is a memoir written by Elbert Lenrow about his relationship with Jack Kerouac, whom he taught at the New School in NewYork when Jack was emerging as a writer and with Allen Ginsberg, both of ...
Burkman, Katherine H., Lenrow, Elbert.
core  

The Agents-are-Substitutes Property in Continuous Generalized Assignment Problems [PDF]

open access: yes
The VCG mechanism has some nice properties if the agents-are-substitutes property holds.For example, for combinatorial auctions the property assures that the VCG mechanism is supported by a pricing equilibrium. The existence of such a pricing equilibrium
Vermeulen,Dries   +2 more
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Ascending sequences in permutations

open access: yesDiscrete Mathematics, 1978
AbstractThe problem of the number p(n , r), (1 ⩽r⩽n), of permutations on the set {1,…,n} with longest ascending subsequence of given length r is considered. By placing further restrictions on the ascending subsequence, combinatorial identities are obtained which allow the explicit calculation of p(n , r) in some cases.
openaire   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Blood flow dynamics in the ascending aorta of patients with bicuspid aortic valve before and after transcatheter aortic valve replacement: a computational fluid dynamics study

open access: yesBMC Cardiovascular Disorders
Background Abnormal blood flow patterns are known to contribute to the ascending aortic dilation in patients with bicuspid aortic valve (BAV). The present study elucidated the blood flow characteristics in the dilated ascending aorta before and after ...
Kang An   +3 more
doaj   +1 more source

Low Price Equilibrium in Multi-Unit Auctions: The GSM Spectrum Auction in Germany [PDF]

open access: yes
The second-generation GSM spectrum auction in Germany is probably the most clear cut example of a low price outcome in a simultaneous ascending-bid auction.The present paper gives an account of the events, describes the auction rules and market ...
Veronika Grimm   +2 more
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

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