Results 221 to 230 of about 513,389 (355)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A Case of Platypnea-Orthodeoxia Syndrome Caused by Patent Foramen Ovale, Accompanied by Dilated Ascending Aorta, Thoracic Kyphosis and Persistent Eustachian Valve. [PDF]

Respirol Case Rep
Kishimoto A, Namiki T, Ogata Y, Sunabe H, Inui T, Ishikawa H, Watanabe H, Ohta C, Numata R, Kawamatsu N, Machino-Ohtsuka T, Hoshi T, Sakamoto T.   +12 more
europepmc   +1 more source

Endovascular repair of the ascending aorta in patients at high risk for open repair.

Journal of Thoracic and Cardiovascular Surgery, 2015
Prashanth Vallabhajosyula, J. Gottret, J. Bavaria, Nimesh D. Desai, W. Szeto   +4 more
semanticscholar   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study. [PDF]

BMC Cardiovasc Disord
Nilsson F, Lindenberger M, Borg S, Kylhammar D, Dyverfeldt P, Hammaréus F, Jonasson L, Krzynska-Trzebiatowska A, Nilsson L, Trenti C, Engvall J, Swahn E.   +11 more
europepmc   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

Probable Loeys-Dietz Syndrome with aortic root dilatation and multiple arterial tortuosity in resource-limited setting : A case report. [PDF]

Radiol Case Rep
Datta N, Zahan ZA, Akhtar NZ, Choudhury MH, Hasan A, Samiha RA, Hussen MD.   +6 more
europepmc   +1 more source

An Efficient Ascending-Bid Auction for Multiple Objects

, 2004
Lawrence M. Ausubel
semanticscholar   +1 more source

Bicuspid Aortic Valve Is Associated With Altered Wall Shear Stress in the Ascending Aorta

Circulation Cardiovascular Imaging, 2012
A. Barker, M. Markl, J. Bürk, R. Lorenz, J. Bock, S. Bauer, J. Schulz-Menger, F. von Knobelsdorff-Brenkenhoff   +7 more
semanticscholar   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source