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The ascorbic acid paradox

Biochemical and Biophysical Research Communications, 2010
Ascorbic acid (AA) is a common culture medium and dietary supplement. While AA is most commonly known for its antioxidant properties, it is also known to function as a pro-oxidant under select conditions. However, the complexity and often unknown composition of biological culture systems makes prediction of AA behaviour in supplemented cultures ...
Osiecki, Michael   +4 more
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Ascorbic acid as antioxidant

2023
Ascorbic acid, as one of the basic exogenous vitamins, is known for its tremendous antioxidant properties. This review has been prepared to show not only the importance of ascorbic acid as a free radical scavenger, but also to summarize its antioxidant action based on other mechanisms, including activation of intracellular antioxidant systems. Ascorbic
Agnieszka, Gęgotek   +1 more
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Ascorbic Acid in Chloroplasts

Nature, 1963
ASCORBIC acid is found in all green plants, although its concentration may vary greatly. Probably the largest concentration recorded is in the endocarp of the walnut, Juglans regia, which contains between 2 and 3 per cent of the fresh weight. The smallest concentration recorded is possibly that in the vegetable marrow, Cucurbita ovifera, 0.002 per cent
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Ascorbic Acid in Steroidogenesis

Nature, 1967
THE adrenal glands contain the highest concentration of ascorbic acid of any tissue in the body. Changes in the concentrations of ascorbic acid and cholesterol are related to steroid secretion in the adrenal1. Although it has been suggested that ascorbic acid might play a primary part in Steroidogenesis2, its physiological role in the adrenal has not ...
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Ascorbic Acid and Cancer

1996
The relationship of ascorbic acid to cancer has, unfortunately, been one of some confusion. While there have been clinical reports suggesting that high doses of ascorbic acid (vitamin C) can exert an inhibitory effect on the development of cancer, these reports have not been adequately corroborated.
G, Shklar, J L, Schwartz
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Ascorbic Acid and Aging

1996
Ascorbic acid is a low—molecular weight substance present in all aqueous compartments (cytosol, plasma, extracellular fluid) in animals and plants (Sies et al., 1992). Many invertebrates are not able to synthesize ascorbate, whereas the majority of vertebrates (amphibians, reptiles, birds, and mammals) synthesize ascorbate from glucose (Dabrowski, 1990)
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Ascorbic Acid and Warfarin

JAMA: The Journal of the American Medical Association, 1973
To the Editor.— Since Sigell and Fless (214:2035, 1970) mentioned the possible role of ascorbic acid in anticoagulant therapy, letters by Rosenthal (215:1671, 1971), Hume et al (219:1479, 1972), and Smith et al (221:1166, 1972) have related observations on the interaction of ascorbic acid in patients, as well as in dogs and rabbits.
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Ascorbic acid in the brain

Brain Research Reviews, 1993
Ascorbic acid is highly concentrated in the central nervous system. Measurement of the extracellular concentration of ascorbate in animals, mainly by the technique of voltammetry in vivo, has demonstrated fluctuation in release from neuropil, both spontaneously and in response to physical stimulation of the animal and to certain drugs.
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Ascorbic acid oxidase and ascorbic acid oxygenase of Myrothecium verrucaria

Archives of Biochemistry and Biophysics, 1965
Abstract Ascorbic acid (AA) is oxidized by two soluble enzyme systems in spores and mycelium of the fungus, Myrothecium verrucaria. One system, for which the name AA Oxygenase is suggested, catalyzes the reaction: AA + O2 → oxalic acid + threonic acid. Such a system has not been reported before. The enzyme appears to be specific for AA. Ferrous ions,
G A, White, R M, Krupka
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Ascorbic Acid Revisited

Archives of Dermatology, 1977
or topical, will speed the unyielding pace of wound healing. On the other hand, there is a multiplicity of possible impediments to wound heal¬ ing, such as infection, dietary inade¬ quacy, concurrent illness, or allergy. When faced with a problem in wound healing, the clinician simply has to identify and to rectify the impedi¬ ments, allowing normal ...
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