Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
The collective application of shorebird tracking data to conservation
Abstract Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership
Autumn‐Lynn Harrison +71 more
wiley +1 more source
More Inspired, Less Anxious: Well‐Being Impacts of a Self‐Directed Art Museum Visit
ABSTRACT Increasingly, art museums are seen as places that can support human flourishing. We describe a quasi‐experimental investigation of the impacts of a self‐directed art museum visit on adults' subjective well‐being. Data were collected from 363 adults at three art museums in Seattle, WA.
Jessica J. Luke +18 more
wiley +1 more source
Traditional production and main characteristics of Galichki kashkaval
In this study, principles of traditional production and main characteristics of the traditional sheep cheese Galichki kashkaval from Bistra Mountain are presented.
Dushica Santa, Sonja Srbinovska
doaj
Fluoride‐Free Mouthwashes Available Over‐The‐Counter in the US‐An Overview
ABSTRACT Purpose Fluoride‐free mouthwashes (FFM) are commonly used by patients for a variety of cosmetic and/or therapeutic reasons. The purpose of this study was to investigate the composition and purposes of FFM available over‐the‐counter in the US.
Astrid C. Valdivia‐Tapia +3 more
wiley +1 more source
Investigation of Chemical and Processing Hurdle Impacts upon Microbial Control and Physicochemical Quality of Manufactured Pepperoni Products. [PDF]
Crowley CH, Kerry JP, Duffy G.
europepmc +1 more source
Abstract The aim of this study was to investigate the potential effects of monosodium glutamate (MSG), a known flavour enhancer added to many ready‐to‐eat foods, as a feed additive in rainbow trout (Oncorhynchus mykiss). Evaluating the effects of MSG on aquatic organisms will fill the knowledge gap in this field by monitoring the haematological indices
Gonca Alak +16 more
wiley +1 more source
Lime and Fly Ash Co-Solidification Treatment of Oil-Contaminated Soil: Characteristics in Different Water Environments and Evaluation of Engineering Reuse. [PDF]
Yu H, Gao P, Li H, Li M.
europepmc +1 more source
The Unexpected Discovery of Paleocene? Coals in Outcrops Thought to Be Cambrian, Al Huqf, Oman
ABSTRACT Two brown organic deposits were encountered whilst investigating kaolinitic claystones thought to occur at the base of a Cambrian formation at outcrop. The age of these organic deposits is probably Paleocene from palynology. Organic petrography shows that they are subbituminous coals with some oil source potential.
Mohammed H. Al Kindi +4 more
wiley +1 more source
ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall +4 more
wiley +1 more source

