Results 1 to 10 of about 10,736 (198)

Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study [PDF]

Pharmaceuticals
Background: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Farah Maarfi, Mohammed Cherkaoui, Sana Afreen, Mohd Yasir Khan   +3 more
doaj   +2 more sources

A Multicycle Pipelined GCM-Based AUTOSAR Communication ASIP

IEEE Access, 2022
In this paper, we explore two pipeline techniques to enhance performance of communication operations in AUTomotive Open System Architecture (AUTOSAR)-based automotive electronic control units (ECUs), and securing these communication operations using an ...
Ahmed Hamed, M Watheq El-Kharashi, Ashraf Salem   +2 more
exaly   +3 more sources

Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes [PDF]

Animal, 2011
Massese is an Italian dairy sheep breed characterized by animals with black skin and horns and black or apparent grey hairs. Owing to the presence of these two coat colour types, this breed can be considered an interesting model to evaluate the effects ...
L. Fontanesi, S. Dall’Olio, F. Beretti, B. Portolano, V. Russo   +4 more
doaj   +3 more sources

Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination [PDF]

Frontiers in Genetics
ObjectiveCoat color is a complex trait and plays an important role in breed identification. However, information regarding genes associated with coat color in cattle is limited, especially at the skin transcriptome level.MethodsWe investigated the ...
Xin Wang, Longxin Xu, Di Zhou, Yanli Lv, Junda Wu, Yuanfeng Zhao, Mengmeng Ni, Wenzhang Zhou, Kaikai Zhang, Hua Wang, Jipan Zhang   +10 more
doaj   +2 more sources

Comparative FISH-Mapping of MC1R, ASIP, and TYRP1 in New and Old World Camelids and Association Analysis With Coat Color Phenotypes in the Dromedary (Camelus dromedarius)

Frontiers in Genetics, 2019
Melanocortin 1 receptor (MC1R), the agouti signaling protein (ASIP), and tyrosinase related protein 1 (TYRP1) are among the major regulators of pigmentation in mammals.
Fahad Alshanbari, Caitlin Castaneda, Rytis Juras   +2 more
exaly   +3 more sources

Understanding the skin blackening phenomenon in Youzhou Dark goats based on the histological characteristics of melanocytes [PDF]

Journal of Advanced Veterinary and Animal Research
Objective: The study was conducted to identify the molecular mechanism of the phenotype formation of Youzhou black sheep by histological cytology and transcriptomics.
Cancan Chen, Jie Li, Xiaoyan Sun, Jing Jiang, Shipeng Lv, Liangjia Liu, Gaofu Wang, Hangxing Ren   +7 more
doaj   +2 more sources

QFEC ASIP: A Flexible Quad-Mode FEC ASIP for Polar, LDPC, Turbo, and Convolutional Code Decoding

IEEE Access, 2018
In this paper, we extend polar decoding function to our previous design, and propose a flexible quad-mode forward error correction application specific instruction-set processor (QFEC ASIP) that supports polar, low-density parity-check (LDPC), turbo, and
Wan Qiao, Dake Liu
exaly   +3 more sources

Integrated genomic and structural dissection of melanism in Indian leopard (Panthera pardus fusca) [PDF]

BMC Genomics
Background Melanism in wild felids represents an intriguing evolutionary trait, potentially advantageous under specific ecological conditions, but the genetic basis of this phenotype remains unclear in many populations.
Avijit Ghosh, Sachin Kumar, Paresh Porob, Mukesh Thakur, Malay Shukla, Satish Kumar, Sweta Nidhi, Abhishek Singh   +7 more
doaj   +2 more sources

Preliminary investigation of potential links between pigmentation variants and opioid analgesic effectiveness in horses during cerebrospinal fluid centesis [PDF]

BMC Veterinary Research
Background The pleiotropic effects of the melanocortin system show promise in overcoming limitations associated with large variations in opioid analgesic effectiveness observed in equine practice. Of particular interest is variation in the melanocortin-1-
Elouise K. Bacon, Callum G. Donnelly, Rebecca R. Bellone, Bianca Haase, Carrie J. Finno, Brandon D. Velie   +5 more
doaj   +2 more sources

Multicenter proteome-wide Mendelian randomization study identifies causal plasma proteins in melanoma and non-melanoma skin cancers [PDF]

Communications Biology
This study addresses the diagnostic and therapeutic challenges in malignant melanoma (MM) and non-melanoma skin cancers (NMSC). We aim to identify circulating proteins causally linked to MM and NMSC traits using a multicenter Mendelian randomization (MR)
Yajia Li, Qiangxiang Li, Ziqin Cao, Jianhuang Wu   +3 more
doaj   +2 more sources