Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study. [PDF]
Pharmaceuticals (Basel)Background: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Maarfi F +3 more
europepmc +2 more sources
The ASIP Cys-98 Allele Is Not Associated With Black Coat Color in Water Buffaloes. [PDF]
Anim GenetAnimal Genetics, Volume 57, Issue 2, April 2026.
de Moraes JVS +6 more
europepmc +2 more sources
Influence of MC1R Gene Variants on Coat Color of Indicine Cattle Breeds. [PDF]
Anim GenetABSTRACT Indicine cattle display a broad range of coat colors, representing a relevant and breed‐defining trait required for registration in breeder association. Among the genes involved in pigmentation, MC1R stands out for modulating the synthesis of melanin‐related proteins and remains poorly explored in indicine cattle breeds. Therefore, we aimed to
Maciel SVSA +12 more
europepmc +2 more sources
Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. [PDF]
PLoS ONE, 2012 Beside its role in melanogenesis, the agouti signaling protein (ASIP) has been related to obesity. The potentially crucial role in adipocyte development makes it a tempting candidate for economic relevant, fat related traits in farm animals.
Elke Albrecht +3 more
doaj +1 more source
Animals, 2022 Agouti signalling protein (ASIP) is a coat colour-related protein and also is a protein-related to lipid metabolism, which had first been found in agoutis.
Tao Xie +8 more
doaj +1 more source
Skin transcriptomic and selection signature analyses identify <i>ASIP</i> as a key gene in cattle coat color determination. [PDF]
Front GenetObjectiveCoat color is a complex trait and plays an important role in breed identification. However, information regarding genes associated with coat color in cattle is limited, especially at the skin transcriptome level.MethodsWe investigated the ...
Wang X +10 more
europepmc +2 more sources
Factors Affecting Multiple Paternity: Insights From the Eastern Quoll (<i>Dasyurus viverrinus</i>). [PDF]
Ecol EvolEastern quolls (Dasyurus viverrinus) exhibit multiple paternity in approximately half of all litters. Reproductive success is correlated with heavier weight, youth, and being black rather than fawn colour morph. A cross‐species analysis indicates that high rates of multiple paternity within the Dasyuridae area correlated with shorter lifespan and ...
Brockett BM +7 more
europepmc +2 more sources
Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits. [PDF]
Evol ApplABSTRACT Horses are major domestic animals and cultural symbols that have accompanied humans for millennia. They underpin transport, agriculture, warfare and sport, and also provide a model for studying domestication, complex traits and adaptive evolution.
Lu Y +6 more
europepmc +2 more sources
Genetics Selection Evolution, 2019 Background In quail, two feather colour phenotypes i.e. fawn-2/beige and yellow are associated with the ASIP locus. The aim of our study was to characterize the structural modifications within this locus that explain the yellow mutation (large deletion ...
Annie Robic +10 more
doaj +1 more source
Genetic characterization of coat color genes in Brazilian Crioula sheep from a conservation nucleus [PDF]
Pesquisa Agropecuária Brasileira, 2017 : The objective of this work was to identify single nucleotide polymorphisms (SNPs) in resequencing data from MC1R, ASIP, and TYRP1 genes derived from Crioula sheep (Ovis aris) with different coat colors.
Lilian Cristina Gomes Cavalcanti +7 more
doaj +1 more source