Results 51 to 60 of about 174,886 (213)

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

open access: yesAdvanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha   +13 more
wiley   +1 more source

Denationaliserad straffrätt - vilka utmaningar står för dörren?

open access: yesNordisk Tidsskrift for Kriminalvidenskab, 2012
See abstract in article.
Petter Asp
doaj   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

open access: yesAdvanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo   +14 more
wiley   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang   +9 more
wiley   +1 more source

Analyse: The Comparison of Czech and Foreign ASP/SAAS Providers [PDF]

open access: yesJournal on Efficiency and Responsibility in Education and Science, 2008
This report gives an overview of the current Application Service Provider´s (ASP) market, especially the offered services. A questionnaire was sent to more than 20 companies which offer some kind of ASP / SaaS, but none of them replied.
Beer Daniela
doaj  

Subcutaneous defibrillator implantation as a bridge until left ventricular function normalizes

open access: yesClinical Case Reports, 2017
Key Clinical Message Patients with reversible cardiac impairment may be, at least temporarily, at high risk of SCD and may go unprotected for considerable time.
Antonio Bisignani   +6 more
doaj   +1 more source

Anmeldelse af Annika Suominen: The Principle of Mutual Recognition in Cooperation in Criminal Matters. A study of the principle in four framework decisions and in the implementation legislation in the Nordic Member State.

open access: yesNordisk Tidsskrift for Kriminalvidenskab, 2014
Review of Annika Suominen:The Principle of Mutual Recognition in Cooperation in Criminal Matters. A study of the principle in four framework decisions and in the implementation legislation in the Nordic Member State.
Petter Asp
doaj   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

open access: yesAdvanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru   +2 more
wiley   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu   +5 more
wiley   +1 more source

FROM IPAB TO ASP: THE EVOLUTION OF DECISIONAL PROCESSES

open access: yesScience & Philosophy, 2014
This study aims to analyze the evolution of decision-making processes through the transformation of The Public Institution of Assistance and Charity (IPAB), in Public Corporations aimed to the Person (ASP). Public corporations of services oriented to the
Dario Recubini
doaj  

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