Results 61 to 70 of about 174,886 (213)

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Rest

Global Qualitative Nursing Research, 2015
Rest is a health-related phenomenon. Researchers have explored the phenomenon of rest, but further concept development is recommended. The aim of my study was to develop and describe a concept of rest, from interviews with a total of 63 participants ...
Margareta Asp
doaj   +1 more source

Ne bis in idem

Nordisk Tidsskrift for Kriminalvidenskab, 2010
See abstract in article.
Petter Asp
doaj   +1 more source

Microsphere‐Modulated Sensing‐in‐Energy Supercapacitor With Self‐Filtering Ultra‐Large Signal Under High‐g Shocks

Advanced Science, EarlyView.
To overcome severe signal oscillation under extreme impact conditions, this work presents a Sensing‐in‐Energy microdevice which integrates a MEMS inertial structure directly within a supercapacitor electrolyte cavity. Utilizing shock‐driven transient contact and electrolyte damping for signal self‐filtering, it achieves weak‐oscillation, large ...
Zhihao Zheng, Yiqun Wang, Kaiyou Liu, Shancheng Luan, Yajiang Yin, Xiaofeng Wang, Keren Dai, Zheng You   +7 more
wiley   +1 more source

Harmonisation of Penalties and Sentencing within the EU

Bergen Journal of Criminal Law and Criminal Justice, 2013
Volume 1, Issue 1, 2013, pp. 53–62.
Petter Asp
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Dynamically insert the forest plot into a web page: The full Javascript codes [PDF]

Computational Ecology and Software
In present study a method that enables users to dynamically insert the forest plot into a web page was presented. In this method, I created a Javascript module for generating and inserting a HTML table, including an entry function and two sub-functions ...
WenJun Zhang
doaj  

Diagnosis of intrahepatic cholangiocarcinoma with CEUS

Journal of Ultrasonography
Intrahepatic cholangiocarcinoma (ICC) is a rare, heterogeneous, highly lethal tumor of the biliary tract. Due to the lack of effective treatments, an early identification of ICC is essential to achieve the best outcome in terms of therapy and prognosis ...
Velardi Giancarlo Gismondo, Lico Matilde, Teti Angela, Maccarone Rosario, Casuscelli Giuseppe, Militano Letterio, Trecroci Ilaria Vittoria, Mendicino Maria, Parlati Antonello, De Caridi Adele, Loria Giuseppe, Loria Saverio, Loria Sveva, Gambardella Denise, Tedesco Manfredo, Frosina Francesca, Falco Pierluigi, Loria Francesco   +17 more
doaj   +1 more source

Three contaminated sites in southern Italy. The Neonatal Environment and Health Outcomes cohort: protocol for a longitudinal birth cohort study

BMJ Open, 2019
IntroductionExposure to environmental contaminants during pregnancy is one of the determinants of child’s future health outcomes. The effect of environmental pollution on pregnant women living in heavily polluted areas is of special interest and, in this
Silvia Ruggieri, Gaspare Drago, Paolo Colombo, Alessio Alesci, Pasquale Augello, Alessandro Bisbano, Antonino Bucolo, Patrizia Dattoli, Raffaella De Sole, Valentina La Runa, Angela Lopez, Lucia Lo Presti, Bruno Magliarditi, Francesco Paravati, Giuseppe Pirillo, Antonino Ziino Colanino, Fabio Cibella   +16 more
doaj   +1 more source