Results 1 to 10 of about 81,095 (195)
IScience, 2022 Summary: Canavan disease (CD) is a devastating neurological disease that lacks effective therapy. Because CD is caused by mutations of the aspartoacylase (ASPA) gene, we introduced the wild-type (WT) ASPA gene into patient iPSCs through lentiviral ...
Lizhao Feng, Xianwei Chen, Qi Cui
exaly +3 more sources
Retracing the path of evolution: polymorphisms of aspA codon 363 shape the fitness of Yersinia pestis [PDF]
Emerging Microbes and InfectionsYersinia pestis, the etiologic agent of plague, is a genetically monomorphic pathogen. By screening 1085 published Y. pestis genomes, we identified an unusual mutation hotspot within codon 363 of the aspartate ammonia-lyase gene aspA with at least six ...
Kai Song +17 more
doaj +2 more sources
The AgI/II Family Adhesin AspA Is Required for Respiratory Infection by Streptococcus pyogenes [PDF]
PLoS ONE, 2013 Streptococcus pyogenes (GAS) is a human pathogen that causes pharyngitis and invasive diseases such as toxic shock syndrome and sepsis. The upper respiratory tract is the primary reservoir from which GAS can infect new hosts and cause disease.
Angela H Nobbs +2 more
exaly +2 more sources
Cloning of the Aspartase Gene (aspA) of Escherichia coli [PDF]
Microbiology (United Kingdom), 1984 The aspartase gene (aspA) of Escherichia coli has been isolated in two plasmids, pGS73 and pGS94, which contain segments of bacterial DNA (12.5 and 2.8 kb, respectively) inserted into the tet gene of the vector pBR322. The plasmids were constructed by sequential sub-cloning from a larger ColE1-frd+ hybrid plasmid.
J R Guest
exaly +3 more sources
Nuclear track autoradiography for radon-related radiobiological hazards in Abu-Sannan Petroleum Area, Egypt [PDF]
Scientific ReportsAbu-Sannan Petroleum Area (ASPA) is situated in Egyptian Western Desert and presents a suitable site for oil exploration. This study aimed to evaluate the radiological hazards linked to technologically enhanced naturally occurring radioactive materials ...
Aya Abdelrazk +3 more
doaj +2 more sources
Genomics, 1994 Canavan disease, or spongy degeneration of the brain, is a severe leukodystrophy caused by the deficiency of aspartoacylase (ASPA). Recently, a missense mutation was identified in human ASPA coding sequence from patients with Canavan disease. The human ASPA gene has been cloned and found to span 29 kb of the genome. Human aspartoacylase is coded by six
Reuben Matalon
exaly +3 more sources
Asperulosidic acid inhibits the PI3K/Akt/NF-κB pathway to suppress endotoxin-induced uveitis [PDF]
Frontiers in MedicineIntroductionUveitis, a severe inflammatory disease affecting the uvea, is associated with visual impairment and irreversible blindness. Asperulosidic Acid (ASPA), derived from Hedyotis diffusa, is known for its notable anti-inflammatory and antioxidant ...
Yong Du +8 more
doaj +2 more sources
, 2013 Artículo corto que aborda de manera descriptiva la realización de la III Cumbre América del Sur/Países Árabes (ASPA) que tuvo lugar en Lima, Perú, en octubre de 2012.
Cuadro, Mariela
core +2 more sources
Identification of stable reference genes in Edwardsiella ictaluri for accurate gene expression analysis. [PDF]
PLoS ONEEdwardsiella ictaluri is a Gram-negative bacterium causing enteric septicemia of catfish (ESC), leading to significant economic losses in the catfish farming industry.
Jingjun Lu +5 more
doaj +2 more sources
Assessing Gender Equality in Italian Animal Science: A Case Study on Academic Careers and Research Outcomes [PDF]
AnimalsThis paper focuses on gender issues within the Italian Animal Science and Production Association (ASPA), which includes both academic and non-academic researchers involved in animal sciences.
Anna Sandrucci +2 more
doaj +2 more sources