Results 11 to 20 of about 81,114 (212)

Supervised learning of protein variant effects across large-scale mutagenesis datasets. [PDF]

Protein Sci
Abstract The increasing availability of data from multiplexed assays of variant effects (MAVEs) enables supervised model training against large quantities of experimental data to learn sequence‐function relationships. Variant effect scores from MAVEs can, however, be influenced by the experimental method and library composition, resulting in experiment‐
Schulze TK, Blaabjerg LM, Cagiada M, Lindorff-Larsen K.   +3 more
europepmc   +2 more sources

Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease. [PDF]

PLoS ONE, 2011
Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate.
Nadine Mersmann, Dmitri Tkachev, Ruth Jelinek, Philipp Thomas Röth, Wiebke Möbius, Torben Ruhwedel, Sabine Rühle, Wolfgang Weber-Fahr, Alexander Sartorius, Matthias Klugmann   +9 more
doaj   +1 more source

Self-Assembling Nano- and Microparticles of Chitosan L- and D-Aspartate: Preparation, Structure, and Biological Activity

Materials Proceedings, 2023
The paper considers the formative processes of chiral nano- and microparticles in solutions of D-aminoglucan chitosan (CS) in L- and D-aspartic acid (AspA) by means of the counterionic condensation of components and the stabilization of particles by a ...
Anna Shipovskaya, Xenia Shipenok, Tatiana Lugovitskaya, Tatiana Babicheva   +3 more
doaj   +1 more source

Structure and supramolecular ordering of chitosan L- and D-aspartates [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023
Chitosan (CS) with a viscosity-average molecular weight of 200 kDa and a deacetylation degree of 82 mol%, produced by Bioprogress Ltd. (RF) has been used in this work.
Shipenok, Xenia M., Shipovskaya, Anna B.
doaj   +1 more source

Mapping the degradation pathway of a disease-linked aspartoacylase variant.

PLoS Genetics, 2021
Canavan disease is a severe progressive neurodegenerative disorder that is characterized by swelling and spongy degeneration of brain white matter.
Sarah K Gersing, Yong Wang, Martin Grønbæk-Thygesen, Caroline Kampmeyer, Lene Clausen, Martin Willemoës, Claes Andréasson, Amelie Stein, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen   +9 more
doaj   +1 more source

Aspartoacylase promotes the process of tumour development and is associated with immune infiltrates in gastric cancer

BMC Cancer, 2023
Background Aspartoacylase (ASPA) is a gene that plays an important role in the metabolic reprogramming of cancer. However, the clinical relevance of ASPA in gastric cancer (GC) has not been demonstrated.
Yalin Han, Xuning Wang, Maolin Xu, Zhipeng Teng, Rui Qin, Guodong Tan, Peng Li, Peng Sun, Hongyi Liu, Li Chen, Baoqing Jia   +10 more
doaj   +1 more source

Aspa marginata

, 2023
Aspa marginata (Gmelin, 1791) Plate 4 C * Buccinum marginatum Gmelin, 1791: 3486. Buccinum marginatum L. — Brocchi 1814: 332, pl. 4, fig. 17. Cassis marginata — Borson 1821: 228, pl. 1, fig. 19. Murex retusus Borson 1821: 59, pl.1, fig. 3. Ranella laevigata Lamarck 1822: 154. Ranella marginata — Brongniart 1823: 65, pl. 6, fig. 7.
Sacchetti, Claudia, Landau, Bernard, Ávila, Sérgio P.   +2 more
openaire   +2 more sources

Role of aspartate ammonia-lyase in Pasteurella multocida

BMC Microbiology, 2020
Background Pasteurella multocida is responsible for a highly infectious and contagious disease in birds, leading to heavy economic losses in the chicken industry. However, the pathogenesis of this disease is poorly understood.
Zui Wang, Li Li, Peng Liu, Chen Wang, Qin Lu, Lina Liu, Xiaozhong Wang, Qingping Luo, Huabin Shao   +8 more
doaj   +1 more source

ASPA Congress - Poultry - Abstracts

Italian Journal of Animal Science, 2010
the Editors
doaj   +2 more sources

Physical activity assessment in patients with axial spondyloarthritis compared to healthy controls: a technology-based approach.

PLoS ONE, 2014
IntroductionTraditionally, assessment in axial Spondyloarthritis (aSpA) includes the evaluation of the capacity to execute tasks, conceptualized as physical function.
Thijs Willem Swinnen, Tineke Scheers, Johan Lefevre, Wim Dankaerts, Rene Westhovens, Kurt de Vlam   +5 more
doaj   +1 more source