Results 101 to 110 of about 202,771 (390)

Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance

Advanced Science
Extensive fibrous stroma plays an important role in gemcitabine (GEM) resistance. However, the mechanism by which pancreatic cancer cells interact with pancreatic stellate cells (PSCs) to promote GEM resistance remains unclear.
Miao Yu, Mingxin Su, Zhenfeng Tian, Lele Pan, Zongmeng Li, Enlai Huang, Yinting Chen   +6 more
doaj   +1 more source

Metallkomplexe mit biologisch wichtigen Liganden, LXVIII [PDF]

, 1993
The trischelate complexes of the dianion of aspartic acid and -methylaspartic acid (5-C5Me5) (R = H, Me) form adducts with alkali iodides MI (M = Li, Na, K).
Beck, Wolfgang, Bergs, Ralph, Sünkel, Karlheinz   +2 more
core   +1 more source

Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials

Advanced Healthcare Materials, EarlyView.
The production of recombinant proteins represents a fundamental step in the characterisation of marine invertebrate adhesives and in the development of bio‐inspired glues. The association of these proteins with other components such as ions, proteins, polysaccharides, or polymers enables the fabrication of biomaterials for various healthcare ...
Alessandra Whaite, Emilie Duthoo, Mathilde Lefevre, Elise Hennebert, Patrick Flammang   +4 more
wiley   +1 more source

Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]

, 2017
[FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura, Bortolus, Marco, Carbonera, Donatella, Costantini, Paola, DE FILIPPIS, Vincenzo, DE ROSA, Edith, Doni, Davide, Galazzo, Laura, Maso, Lorenzo   +8 more
core   +1 more source

Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation

Journal of Virology, 2019
Viruses rely on their infected host cells to provide nutrients and energy for replication. Vaccinia virus, the prototypic member of the poxviruses, which comprise many significant human and animal pathogens, prefers glutamine to glucose for efficient ...
Anil Pant, Shuai Cao, Zhilong Yang
semanticscholar   +1 more source

Guides for Developing Hundreds of Novel Chiral MXenes and MBenes Nanosheets/Quantum Dots for Next‐Generation Chiral Engineered Biomaterials Applications

Advanced Healthcare Materials, EarlyView.
The emerging field of MXene/MBene materials has progressed rapidly, advancing diverse research fields, including biomedical engineering, biomedicine, agriculture, and the environment. This nanobiotechnology can tackle longstanding challenges in these areas.
Alireza Rafieerad, Ahmad Amiri
wiley   +1 more source

Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study

Haematologica, 2019
Asparagine levels in cerebrospinal fluid and serum asparaginase activity were monitored in children with acute lymphoblastic leukemia treated with pegylated-asparaginase. The drug was given intravenously at a dose of 2,500 IU/m2 on days 12 and 26.
C. Rizzari, C. Lanvers-Kaminsky, M. Valsecchi, A. Ballerini, C. Matteo, J. Gerss, Gudrun Wuerthwein, D. Silvestri, A. Colombini, V. Conter, A. Biondi, M. Schrappe, A. Moericke, M. Zimmermann, A. von Stackelberg, C. Linderkamp, M. Frühwald, Sabine Legien, A. Attarbaschi, Bettina Reismüller, D. Kasper, P. Smisek, J. Starý, L. Vinti, E. Barisone, R. Parasole, C. Micalizzi, M. Zucchetti, J. Boos   +28 more
semanticscholar   +1 more source

Ein neues Asparagin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1886
n ...
openaire   +2 more sources

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, EarlyView.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4*

Leukemia and Lymphoma, 2019
The efficacy of asparaginase in acute lymphoblastic leukemia (ALL) is dependent on depletion of asparagine, an essential amino acid for ALL cells. The target level of plasma asparaginase activity to achieve asparagine depletion has been between 0.05 and ...
R. Schore, M. Devidas, A. Bleyer, G. Reaman, N. Winick, M. Loh, E. Raetz, W. Carroll, S. Hunger, A. Angiolillo   +9 more
semanticscholar   +1 more source