Results 111 to 120 of about 202,771 (390)

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

Advanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li, Ping Deng, Tengfei Fan, Yuchen Qu, Miduo Tan, Yidan Liang, Peng Gao, Yongchun Peng, Mingke Qin, Sheng Jie, Rongrong Hao, Liting Wang, Lei Zhang, Chunhai Chen, Mindi He, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Rui Tian, Min Li, Zhengping Yu, Zhou Zhou, Huifeng Pi   +24 more
wiley   +1 more source

Repositioning the Catalytic Triad Aspartic Acid of Haloalkane Dehalogenase: Effects on Stability, Kinetics, and Structure [PDF]

, 1997
Haloalkane dehalogenase (DhlA) catalyzes the hydrolysis of haloalkanes via an alkyl-enzyme intermediate. The covalent intermediate, which is formed by nucleophilic substitution with Asp124, is hydrolyzed by a water molecule that is activated by His289 ...
Abbreviations A, Chen Y. W., Damborský J., Fersht A. R., Huang C. Y., Janssen D. B., Kawasaki H., Keuning S., Kraulis P. J., Kulakova A. N., Kumar A., Kunkel T. A., Leatherbarrow R. J., Li Y., Mendes P., Nagata Y., Nobbs T. J., Ollis D. L., Ordentlich A., Pries F., Pries F., Sambrook J., Sanger F., Schanstra J. P., Schanstra J. P., Schanstra J. P., Schmid F. M., Schrag J. D., Schrag J. D., Sprang S., Studier F. W., Verschueren K. H. G., Verschueren K. H. G., Verschueren K. H. G.   +33 more
core   +4 more sources

Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity [PDF]

, 2020
Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular
Araujo Garrido, Juan Luis, Bernal Bayard, Joaquín, Ramos Morales, Francisco   +2 more
core   +1 more source

Toward a Species Search Engine: KISSE Offers a Rigorous Statistical Framework for Bone Collagen Tandem Mass Spectrometry Data

Advanced Science, EarlyView.
The Species Search Engine (KISSE) is a novel statistical approach for identifying species from collagen peptides, using a curated library of sequences and their relative abundances derived from shotgun proteomics. Abstract DNA and bone collagen are two key sources of resilient molecular markers used to identify species from their remains.
Hassan Gharibi, Amir Ata Saei, Alexey L. Chernobrovkin, Susanna L. Lundstrom, Hezheng Lyu, Zhaowei Meng, Akos Vegvari, Massimilliano Gaetani, Roman A. Zubarev   +8 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

A Mouse Amidase Specific for N-terminal Asparagine: the gene, the enzyme, and their function in the N-end rule pathway [PDF]

, 1996
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In both fungi and mammals, the tertiary destabilizing N-terminal residues asparagine and glutamine function through their conversion, by enzymatic ...
Arfin, Stuart M., Bradshaw, Ralph A., Copeland, Neal G., Grigoryev, Sergei, Jenkins, Nancy A., Kwon, Yong Tae, Stewart, Albert E., Varshavsky, Alexander   +7 more
core  

Improvement of Soybean Agrobacterium-Mediated Transformation Efficiency by Adding Glutamine and Asparagine into the Culture Media

International Journal of Molecular Sciences, 2018
As a genetically modified crop, transgenic soybean occupies the largest global scale with its food, nutritional, industrial, and pharmaceutical uses.Efficient transformation is a key factor for the improvement of genetically modified soybean. At present,
Li Chen, Yupeng Cai, Xiujie Liu, Weiwei Yao, Chen Guo, Shi Sun, Cunxiang Wu, Bingjun Jiang, T. Han, W. Hou   +9 more
semanticscholar   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Reversing Lanmodulin's Metal‐Binding Sequence in Short Peptides Surprisingly Increases the Lanthanide Affinity

Angewandte Chemie, EarlyView.
Accidentally reversing the lanthanide‐binding sequences of lanmodulin‐inspired short peptides lead to the serendipitous discovery of a set of peptides with a one order of magnitude higher lanthanide‐binding affinity than the uncapped peptides synthesised in the correct direction.
Sophie M. Gutenthaler‐Tietze, Jerome Kretzschmar, Satoru Tsushima, Robin Steudtner, Björn Drobot, Lena J. Daumann   +5 more
wiley   +2 more sources

Ueber das Asparagin [PDF]

Annalen der Pharmacie
n ...
openaire   +5 more sources