Results 141 to 150 of about 99,734 (259)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

LumbriCyc: towards metabolic modelling of earthworms. [PDF]

NPJ Syst Biol Appl
von Kamp A.
europepmc   +1 more source

Identification and Phylogenetic Characterisation of Novel Adeno‐Associated Virus Capsids in Non‐Human Primate Tissues

Cell Proliferation, EarlyView.
AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu, Kai Xu, Yali Ding, Kailun Liu, Jing Liu, Zongren Hou, Rui Niu, Ning Yang, Hualing Qin, Baoyang Hu, Ying Zhang, Wei Li   +11 more
wiley   +1 more source

Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics. [PDF]

Front Immunol
Gopalakrishnan R, Kannan K, Gunasekaran R, Ramachandran P, Ganapathy D, Sivaperumal P.   +5 more
europepmc   +1 more source

l-Asparagine [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Two Metschnikowia nectar yeast species have similar volatile profiles but elicit differential foraging in bee pollinators

Ecological Entomology, EarlyView.
Yeasts that specialize in flower nectar play an important role in pollination ecology. Metschnikowia reukaufii and Metschnikowia koreensis were the most prevalent nectar yeasts found in our field sites. Bee pollinators exhibited different behavioural responses to nectar yeasts in field experiments. Bees visited more flowers with M.
M. Elizabeth Moore, Lindsey Wilson, Nathan Brandt, Ayako Wada‐Katsumata, Ahmed M. Saveer, Coby Schal, Robert R. Dunn, Rebecca E. Irwin, Caiti Smukowski Heil   +8 more
wiley   +1 more source

NFC-enabled sensing platform for the onsite determination of asparagine in food. [PDF]

Mater Today Bio
Lee HS, Panesar RK, Gonzalez-Macia L, Barandun G, Güder F.   +4 more
europepmc   +1 more source

Host plant richness and abundance drive populations of a super‐generalist xylem‐feeding insect

Ecological Entomology, EarlyView.
Philaenus spumarius abundance was assessed across 93 sites and four habitat types (olive groves, vineyards, meadows, and field margins) within eight heterogeneous agricultural landscapes over the year. In spring, nymph abundance was positively associated with herbaceous plant species richness and vegetation cover, highlighting that even super ...
Francesco Sanna, Jacopo Lupoletti, Nicola Mori, Lorenzo Marini   +3 more
wiley   +1 more source

A mammalian, glutaminase-free asparaginase enhances venetoclax activity in preclinical AML models with chromosome 7 deletion. [PDF]

Front Oncol
Majid D, Wang Z, Schalk AM, Yuan B, Tatarata QZ, Root JL, Garza AI, Yassouf MY, Gamal BT, Feri-Borgogno S, Nguyen AH, Konopleva M, Peeters E, Su Y, Reville PK, Ravandi-Kashani F, Lavie A, Abbas HA.   +17 more
europepmc   +1 more source

Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein

The FEBS Journal, EarlyView.
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley   +1 more source