Results 311 to 320 of about 202,771 (390)

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

α-Helical Structure of Antimicrobial Peptides Enhances Their Activity through Molecular Surface Signatures. [PDF]

Biochemistry
Quagliata M, Grabeck J, König K, Papini AM, Rovero P, Neundorf I, Friedrich D.   +6 more
europepmc   +1 more source

Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein

The FEBS Journal, EarlyView.
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley   +1 more source

Three Asparagine insertions in the K13-propeller led to Plasmodiumfalciparum becoming resistant to multiple antimalarial drugs. [PDF]

Int J Parasitol Drugs Drug Resist
Xiang Z, Duan M, Wang S, Zhao H, Zhao W, Li X, Li X, Zeng W, Wu Y, Yang F, Liu X, Tang C, Cui L, Yang Z.   +13 more
europepmc   +1 more source

Calcitonin gene‐related peptide and headache: Comparison of two commonly used assay kits highlights the perils of measuring neuropeptides with enzyme‐linked immunosorbent assays

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This study was undertaken to test the ability of a widely used enzyme‐linked immunosorbent assay (ELISA) kit to detect calcitonin gene‐related peptide (CGRP) isoforms to better understand currently published clinical data.
Michael L. Garelja, Tayla A. Rees, Debbie L. Hay   +2 more
wiley   +1 more source

Safety evaluation of the food enzyme asparaginase from the non-genetically modified <i>Saccharomyces cerevisiae</i> strain ARY-2. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Fernàndez-Fraguas C, Cavanna D, Peluso S, Liu Y.   +16 more
europepmc   +1 more source

Contribution of Amino Acids in Cereal Grain Products to Precision Feed Formulation for Tambaqui (Colossoma macropomum) Using a Digestibility Approach

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Although cereal grain products have low protein content, they can contribute up to 25% of total protein in low‐trophic level/omnivorous fish diets. Thus, understanding the amino acid contribution of these ingredients becomes crucial for meeting the dietary requirements of omnivorous fish.
Danilo C. Proença, Monaliza F. Sena, Janaína G. Araújo, Guilherme W. Bueno, Igo G. Guimarães   +4 more
wiley   +1 more source

Intragenic suppressors of the <i>C. elegans</i> <i>clk-2(qm37)</i> mutation. [PDF]

MicroPubl Biol
Pascal M, Cappadocia L, Hekimi S, Bénard CY.   +3 more
europepmc   +1 more source

The Gfr Uptake System Provides a Context‐Dependent Fitness Advantage to Salmonella Typhimurium SL1344 During the Initial Gut Colonization Phase

Molecular Microbiology, EarlyView.
Diet–microbiota interactions shape colonization resistance. While the microbiota restricts pathogens like Salmonella through nutrient competition, Salmonella can exploit private nutrients such as fructoselysine (FL), abundant in processed foods but inaccessible to most microbes.
Lea Fuchs, Cora Lisbeth Dieterich, Elena Melgarejo Ros, Philipp Keller, Anna Sintsova, Leanid Laganenka, Thomas A. Scott, Christopher Schubert, Shinichi Sunagawa, Julia A. Vorholt, Jörn Piel, Wolf‐Dietrich Hardt, Bidong D. Nguyen   +12 more
wiley   +1 more source

The Causal Relationship Between Circulating Inflammatory Proteins and Tinnitus: A Mendelian Randomization Study Mediated by Blood Metabolites. [PDF]

Brain Behav
Chen K, Cai Y.
europepmc   +1 more source