Results 341 to 350 of about 202,771 (390)

Base Editing‐Mediated Targeted Evolution of Populus CesA8 Boosts Cellulose Production

Plant Biotechnology Journal, EarlyView.
Xinrui Jia, Miao Zhang, Ping Zhu, Yu Zhong, Jinshan Gui   +4 more
wiley   +1 more source

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Nature Cancer, 2022
The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate.
Christopher J Halbrook, Peter Sajjakulnukit, Ji Zhang   +2 more
exaly   +2 more sources

Asparagine bioavailability governs metastasis in a model of breast cancer

Nature, 2018
Elvin Wagenblast, Sun Y Kim, Lisa Fish
exaly   +2 more sources

Glutamine and asparagine activate mTORC1 independently of Rag GTPases

Journal of Biological Chemistry, 2020
Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy.
Delong Meng, Huanyu Wang, Chase H Melick
exaly   +2 more sources

Role of glutamine and interlinked asparagine metabolism in vessel formation

EMBO Journal, 2017
Joanna Kalucka, Nadira Yusupovna Yuldasheva, Jermaine Goveia   +2 more
exaly   +2 more sources

Translational reprogramming marks adaptation to asparagine restriction in cancer

Nature Cell Biology, 2019
While amino acid restriction remains an attractive strategy for cancer therapy, metabolic adaptations limit its effectiveness. Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells.
Gaurav Pathria, Joo S Lee, Kristofferson Tandoc   +2 more
exaly   +2 more sources

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Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Science, 2002
David Lando, Daniel J Peet
exaly   +2 more sources

SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis

Cell Death and Disease, 2019
The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the role of SOX12 and the mechanism by which it is dysregulated in colorectal cancer (CRC) remain unclear.
Weili Han, Dean Tian, Yongzhan Nie
exaly   +2 more sources