Results 351 to 360 of about 202,771 (390)

The conformational locking of asparagine

Chemical Communications, 2012
One dominant structure has been identified analysing the rotational spectrum of asparagine in sharp contrast with the multiconformational behaviour for other amino acids with polar side chains. This locking of the conformational variety to a single conformer has been ascribed to an intramolecular hydrogen bonding network involving α-amine, α-carboxylic
Marcelino Varela, Santiago Mata, Isabel Peña, José L. Alonso, Carlos Cabezas, Juan C. López   +5 more
openaire   +2 more sources

The action of Pseudomonas fluorescens extracts on asparagine and asparagine derivatives

Biochimica et Biophysica Acta, 1960
Abstract Cell-free extracts from Pseudomonas fluorescens hydrolyzed L - and D -asparagine, L - and D -β-aspartohydroxamic acid and α-N-alkyl derivatives of DL -asparagine, but failed to attack L - and D -N-(β-aspartyl)-alkylamines. The extracts also catalyze the formation of β-aspartohydroxamic acid from L - or D -asparagine and ...
N. de Groot, N. Lichtenstein
openaire   +3 more sources

Configuration of the Peptide Link and of Asparagine in Glycyl-L-Asparagine

Nature, 1952
SINCE the geometrical problem of protein structure is mainly that of the configuration of the polypeptide chains, the geometry of the peptide link itself is a matter of prime importance. However, very few crystal-structure data have yet been published from which precise dimensions of the peptide link may be derived. We have recently carried out a three-
Robert B. Corey, R. A. Pasternak, Lewis Katz   +2 more
openaire   +3 more sources

Catalytic deamination of asparagine

Experientia, 1970
Es wird die katalytische Deaminierung des Asparagins mittels Cu++ bei 80°–100°C beschrieben. In diesem Temperaturbereich findet die Reaktion auch in Losungen statt, wahrend die Katalyse im Trockenruckstand bedeutend starker ist. Die optimale Konzentration des Cu++ (bezogen auf das Asparagin) ist 1∶4M.
A. Marx, Maria Sendrea, Maria Petcovici
openaire   +3 more sources

Asparagine Synthetase1, but not Asparagine Synthetase2, is Responsible for the Biosynthesis of Asparagine Following the Supply of Ammonium to Rice Roots

Plant and Cell Physiology, 2015
Asparagine is synthesized from glutamine by the reaction of asparagine synthetase (AS) and is the major nitrogen form in both xylem and phloem sap in rice (Oryza sativa L.). There are two genes encoding AS, OsAS1 and OsAS2, in rice, but the functions of individual AS isoenzymes are largely unknown. Cell type- and NH4(+)-inducible expression of OsAS1 as
Keiki Ishiyama, Soichi Kojima, Noriyuki Konishi, Tomoyuki Yamaya, Miwa Ohashi, Kentaro Nakano, Kentaro Nakano, Keiichi Kanno, Toshihiko Hayakawa   +8 more
openaire   +3 more sources

Structure of Asparagine Monohydrate

Nature, 1961
THE structure of asparagine has been discussed several times during recent years1–5. A number of properties would be better explained by a ring structure than by the conventional straight-chain structure1,2, but on the other hand, the carboxylic group had to be free3.
A. De Vries, Gopinath Kartha
openaire   +3 more sources

ChemInform Abstract: NEW ASPARAGINE ANALOGS

Chemischer Informationsdienst, 1973
AbstractDiaminobernsteinsäuren (I) werden zu (II) geschützt und dann über Anhydride (III) und Halbamide (IV) in die Asparaginsäurederivate (V) übergeführt.
Robert E. Handschumacher, Pauline K. Chang, Louis J. Sciarini   +2 more
openaire   +4 more sources

Production of l-asparagine by tumor cells and the effect of asparagine analogs

Biochemical Pharmacology, 1972
Abstract A rapid assay of the ability of intact cells (10–50 mg) to synthesize l -asparagine and l -aspartic acid, and its application to the evaluation of potential asparagine analogs has been devised. Washed cell preparations were incubated at 37° in Eagle's medium (supplemented with l -glutamine, 2 mM, and l -aspartic acid, 0.05 mM), and the ...
Chou, T, Handschumacher, R
openaire   +3 more sources

The action of mammalian liver enzyme preparations on asparagine and asparagine derivatives

Biochimica et Biophysica Acta, 1960
Abstract α-N-alkyl derivatives of DL -asparagine were not hydrolyzed by rat-liver asparaginase or guinea pig-liver asparaginase. They markedly inhibited the action of these enzymes on L -asparagine. In all cases tested the inhibition was found to be competitive. Rat and guinea pig liver asparaginase did not hydrolyze N-(β- DL -aspartyl)-alkylamines
N. Lichtenstein, N. de Groot
openaire   +3 more sources

Anti-Tumor Bis(N-heterocyclic carbene)Platinum(II) Complex Engages Asparagine Synthetase as an Anti-cancer Target.

Angewandte Chemie, 2019
New anti-cancer platinum(II) compounds with distinctive modes of anti-cancer action are appealing alternatives to combat the drug resistance and improve the efficacy of the clinically used platinum chemotherapy.
D. Hu, Chen Yang, C. Lok, Fangrong Xing, Pui‐yan Lee, Y. Fung, Haibo Jiang, C. Che   +7 more
semanticscholar   +1 more source