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Aspartame and seizures

Amino Acids, 1993
It has been hypothesized that the dietary sweetener aspartame (L-aspartyl-L-phenylalanine methyl ester) might promote seizures and this hypothesis has been argued in the published literature. The current manuscript reviews the biochemical, neurochemical and behavioral experiments that have been carried out in order to assess the hypothesis linking ...
P C, Jobe, J W, Dailey
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Aspartame and Headache

Headache: The Journal of Head and Face Pain, 1988
There is evidence that aspartame consumption can provoke adverse neurological reactions, most notably headache, in a susceptible subset of the population. The available experimental and clinical data on human aspartame consumption and adverse reactions, the concept of chemical headache and its relevance to aspartame-provoked headache, the ...
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The Safety of Aspartame

JAMA: The Journal of the American Medical Association, 1986
To the Editor.— The American Medical Association Council on Scientific Affairs recently reviewed aspartame safety issues.1Aspartame is a new dipeptide sweetener, and US consumption of aspartame within three years of its widespread introduction into the food supply has increased to levels that, after normalization for sweetener potency, are ...
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Interaction of aspartame with selected hydrocolloids: solubility of aspartame

Food Hydrocolloids, 1999
Abstract The interaction of aspartame (APM) with selected hydrocolloids was investigated observing solution characteristics and using scanning electron microscopy. The presence of hydrocolloids improved the solubility of APM in the following decreasing order: CMC and acacia gum>κ-carrageenan and pectin>locust bean gum>guar gum>xanthan>amylopectin ...
W. Wafwoyo, P.M.T. Hansen, G.W. Chism
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Aspartame

Nutrition & Food Science, 1984
This new sweetener has an excellent flavour but some newspaper stories have questioned its ...
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Metabolism of Aspartame in Monkeys

The Journal of Nutrition, 1973
Aspartame (SC-18862, 3-amino-N-(a-carboxyphenethyl)succinarnic acid, methyl ester; the methyl ester of aspartyl-phenylalanine ) is a sweetening agent that organoleptically has about 180 times the sweetness of sugar. Because it so closely resembles naturally occurring dipeptides, it was believed that it would be digested in a similar manner.
J A, Oppermann, E, Muldoon, R E, Ranney
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Treatment of osteoarthritis with aspartame*

Clinical Pharmacology & Therapeutics, 1998
The binding of sweet-tasting compounds in a human (Mcg) Bence-Jones dimer has been characterized by x-ray crystallography. Aspartame binding in this immunoglobulin fragment is remarkable. Unexpected pain relief noted by A.B.E., a crystallographer with diagnosed osteoarthritis, suggested that the accommodation of aspartame in the active site of the ...
A B, Edmundson, C V, Manion
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Conformational flexibility of aspartame

Peptide Science, 2016
ABSTRACTL‐Aspartyl‐L‐phenylalanine methyl ester, better known as aspartame, is not only one of the most used artificial sweeteners, but also a very interesting molecule with respect to the correlation between molecular structure and taste. The extreme conformational flexibility of this dipeptide posed a huge difficulty when researchers tried to use it ...
Claudio, Toniolo, Pierandrea, Temussi
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