Results 131 to 140 of about 4,528 (177)

Aspartame and Susceptibility to Headache

New England Journal of Medicine, 1987
We performed a double-blind crossover trial of challenges with 30 mg of aspartame per kilogram of body weight or placebo in 40 subjects who reported having headaches repeatedly after consuming products containing aspartame. The incidence rate of headache after aspartame (35 percent) was not significantly different from that after placebo (45 percent ...
S S, Schiffman, C E, Buckley, H A, Sampson, E W, Massey, J N, Baraniuk, J V, Follett, Z S, Warwick   +6 more
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Aspartame and aspartame derivatives effect human thrombin catalytic activity

Biophysical Chemistry, 2004
The study of small Asp-Phe analogs was undertaken since this dipeptide sequence is critical in fibrinogen recognition and catalysis. The inhibition of clotting activity by Asp-Phe-methyl ester (aspartame), formyl-Asp-Phe-methyl ester and acetyl-Asp-Phe was biphasic in all cases, indicating the presence of at least two binding sites.
Julie E, Scheffler, Lawrence J, Berliner
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Aspartame

2000
Abstract Aspartame (APM) is a dipeptide of aspartic acid and phen ylalanine that is 180-200 times sweeter than sucrose in solution. Approximately 200 safety and metabolism studies have been conducted on APM and its degradation products, in vitro, in animals and in humans; these studies have been summarized in various monographs and ...
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Aspartame: Review of Safety

Regulatory Toxicology and Pharmacology, 2002
Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume.
Harriett H, Butchko, W Wayne, Stargel, C Phil, Comer, Dale A, Mayhew, Christian, Benninger, George L, Blackburn, Leo M J, de Sonneville, Raif S, Geha, Zsolt, Hertelendy, Adalbert, Koestner, Arthur S, Leon, George U, Liepa, Kenneth E, McMartin, Charles L, Mendenhall, Ian C, Munro, Edward J, Novotny, Andrew G, Renwick, Susan S, Schiffman, Donald L, Schomer, Bennett A, Shaywitz, Paul A, Spiers, Thomas R, Tephly, John A, Thomas, Friedrich K, Trefz   +23 more
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Conformation and hydration of aspartame

International Journal of Peptide and Protein Research, 1991
Conformational free energy calculations using an empirical potential (ECEPP/2) and the hydration shell model were carried out on the neutral, acidic, zwitterionic, and basic forms of aspartame in the hydrated state. The results indicate that as the molecule becomes more charged, the number of low energy conformations becomes smaller and the molecule ...
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Aspartame‐a sweet surprise

Journal of Toxicology and Environmental Health, 1976
The dipeptide ester L-aspartyl-L-phenylalanine methyl ester (APM) has been found to have a remarkably clean, sucrose-like taste with no off flavor and a potency 150-200 times sucrose. Subsequent work has shown that many alpha-amides of L-aspartic acid are sweet. Some results of stability studies and a taste panel evaluation of APM are reported.
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Aspartame-lnduced Urticaria

Annals of Internal Medicine, 1986
Excerpt Aspartame (NutraSweet; G.D. Searle & Co., Skokie, Illinois), the dipeptide composed of aspartic acid and the methyl ester of phenylalanine, is a low-calorie artificial sweetener 180 times s...
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Is Aspartame Safe?

The Diabetes Educator, 1984
Karmeen Kulkarni, Marion Franz
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Aspartame and the inter net

The Lancet, 1999
A, Zehetner, M, McLean
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Aspartame

Canadian Institute of Food Science and Technology Journal, 1988
P, Josephsen, I L, Josephsen, L, Breum
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