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Aspartame and seizures

Amino Acids, 1993
It has been hypothesized that the dietary sweetener aspartame (L-aspartyl-L-phenylalanine methyl ester) might promote seizures and this hypothesis has been argued in the published literature. The current manuscript reviews the biochemical, neurochemical and behavioral experiments that have been carried out in order to assess the hypothesis linking ...
P C, Jobe, J W, Dailey
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Aspartame and Headache

Headache: The Journal of Head and Face Pain, 1988
There is evidence that aspartame consumption can provoke adverse neurological reactions, most notably headache, in a susceptible subset of the population. The available experimental and clinical data on human aspartame consumption and adverse reactions, the concept of chemical headache and its relevance to aspartame-provoked headache, the ...
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Aspartame and aspartame derivatives effect human thrombin catalytic activity

Biophysical Chemistry, 2004
The study of small Asp-Phe analogs was undertaken since this dipeptide sequence is critical in fibrinogen recognition and catalysis. The inhibition of clotting activity by Asp-Phe-methyl ester (aspartame), formyl-Asp-Phe-methyl ester and acetyl-Asp-Phe was biphasic in all cases, indicating the presence of at least two binding sites.
Julie E, Scheffler, Lawrence J, Berliner
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