Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu+9 more
wiley +1 more source
Characterization of an aspartate aminotransferase encoded by YPO0623 with frequent nonsense mutations in Yersinia pestis. [PDF]
Jin J+16 more
europepmc +1 more source
Reaction of aspartate aminotransferase apoisozymes with glyceraldehyde‐3‐P: Effect of NaBH4 treatment and subsequent reactivation by pyridoxal‐5′‐P [PDF]
Jerome S. Nisselbaum, Levy Kopelovich
openalex +1 more source
Macro-aspartate aminotransferase is a possible cause of persistent isolated elevated aspartate aminotransferase level [PDF]
Karen Hk Luk+3 more
openaire +3 more sources
Cryogel‐Based Dendritic Cell Immunotherapy for Post‐Surgical Breast Cancer Treatment
A multifunctional GelMA cryogel enables dendritic cell immunotherapy that synergizes with doxorubicin and PD‐1 blockade, driving robust post‐surgical T‐cell immunity and suppressing TNBC recurrence. Abstract Triple‐negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options.
Lam‐Duc‐Huy Nguyen+7 more
wiley +1 more source
The interaction of aliphatic and aromatic dicarboxylic acids with aspartate aminotransferase [PDF]
Harriet E. Harris+3 more
openalex +1 more source
A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du+9 more
wiley +1 more source
Fluorescence of Aromatic Amino Acids in a Pyridoxal Phosphate Enzyme: Aspartate Aminotransferase
Martine Arrio‐Dupont
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Evaluation and Recalculation of Manufacturer’s Instrument-Specific Aspartate Aminotransferase Values for Reference Sera [PDF]
Ronald H. Laessig+3 more
openalex +1 more source