Results 181 to 190 of about 414,727 (380)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

open access: yesAdvanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu   +9 more
wiley   +1 more source

Characterization of an aspartate aminotransferase encoded by YPO0623 with frequent nonsense mutations in Yersinia pestis. [PDF]

open access: yesFront Cell Infect Microbiol, 2023
Jin J   +16 more
europepmc   +1 more source

Cryogel‐Based Dendritic Cell Immunotherapy for Post‐Surgical Breast Cancer Treatment

open access: yesAdvanced Science, EarlyView.
A multifunctional GelMA cryogel enables dendritic cell immunotherapy that synergizes with doxorubicin and PD‐1 blockade, driving robust post‐surgical T‐cell immunity and suppressing TNBC recurrence. Abstract Triple‐negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options.
Lam‐Duc‐Huy Nguyen   +7 more
wiley   +1 more source

The interaction of aliphatic and aromatic dicarboxylic acids with aspartate aminotransferase [PDF]

open access: green, 1972
Harriet E. Harris   +3 more
openalex   +1 more source

Nanoscale Metal‐Organic Framework‐Based Self‐Monitoring Oxygen Economizer and ROS Amplifier for Enhanced Radiotherapy‐Radiodynamic Therapy

open access: yesAdvanced Science, EarlyView.
A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du   +9 more
wiley   +1 more source

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