Results 251 to 260 of about 189,959 (292)

Prognostic value of aspartate aminotransferase/alanine aminotransferase ratio in hepatocellular carcinoma after hepatectomy. [PDF]

BJS Open
Huo RR, Pan LX, Wu PS, Liang XM, You XM, Ma L, Zhong JH.   +6 more
europepmc   +1 more source

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Construction and validation of a preoperative prognostic model integrating the novel aspartate aminotransferase-albumin score for hepatocellular carcinoma patients undergoing liver resection. [PDF]

Ann Hepatobiliary Pancreat Surg
Ikuta S, Aihara T, Kasai M, Nakajima T, Yamanaka N.   +4 more
europepmc   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Assessment of aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index score on women with intrahepatic cholestasis of pregnancy. [PDF]

AJOG Glob Rep
Cemortan M, Iliadi-Tulbure C, Sagaidac I, Cernetchi O.   +3 more
europepmc   +1 more source

Comparison of MR elastography, FibroScan and aspartate aminotransferase to platelets ratio index for the non-invasive assessment of liver fibrosis

, 2007
Laurent Huwart, Christine Sempoux, Najat Salameh, Jacques Jamart, Laurence Annet, Ralph Sinkus, Frank Peeters, Leon terBeek, Yves Horsmans, Bernard E. Van Beers   +9 more
openalex   +1 more source

Establishment of the histopathologics scores from hepatic lesion and determination of the normal values of enzymes aspartate aminotransferase and creatine kinase in chickens

, 2008
Lucas Brunelli de Moraes
openalex   +1 more source

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Macromolecular aspartate aminotransferase

European Journal of Gastroenterology & Hepatology, 1998
Macroenzymes are serum enzymes that have a greater molecular mass than the corresponding enzyme normally found in serum (Klonoff. West J Med 1980; 133: 392-407). Serum AST (aspartate aminotransferase) has rarely been reported to complex with immunoglobulins, resulting in an elevation in serum AST activity.
J, Tharakan, A, Hossenbocus, M J, Arthur
openaire   +2 more sources

Aspartate aminotransferase ofLactobacillus murinus

Folia Microbiologica, 1988
Aspartate aminotransferase from Lactobacillus murinus is thermostable, its activity being not changed for two months at temperatures between 4 and -70 degrees C. Maximum activity was observed at 40 degrees C and pH 7.3 in phosphate buffer (30 mmol/L). delta G* Value of 26.3 kJ/mol was calculated from the Arrhenius plot.
G, Rollan, M C, Manca de Nadra, A, Pesce de Ruiz Holgado, G, Oliver   +3 more
openaire   +2 more sources