Results 101 to 110 of about 16,662 (295)

Evidence that ³¹P NMR is a sensitive indicator of small conformational changes in the coenzyme of aspartate aminotransferase [PDF]

, 1989
Klaus D. Schnackerz, Gudrun WAHLER, M. G. Vincent, Johan N. Jansonius   +3 more
openalex   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Application of sensor structures based on a photoelectric transducer to determine the activity of aspartate and alanine aminotransferases in blood plasma [PDF]

, 2023
A. V. Kozinetz, О. V. Tsymbalyuk, S. V. Litvinenko   +2 more
openalex   +1 more source

Interactions between Cystathionase and Aspartate Aminotransferase

Journal of Biological Chemistry, 1972
The interaction of cystathionase with the apoprotein of the enzyme aspartate aminotransferase induces, concomitant with inhibition of cystathionase activity, an increase in aminotransferase activity. The interaction between both proteins brings about a change in the amplitude of the circular dichroic band corresponding to pyridoxal-5-P bound to the ...
openaire   +2 more sources

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. [PDF]

Acta Crystallogr F Struct Biol Commun, 2015
Abendroth J, Choi R, Wall A, Clifton MC, Lukacs CM, Staker BL, Van Voorhis W, Myler P, Lorimer DD, Edwards TE.   +9 more
europepmc   +1 more source

Aspartate aminotransferase: interaction with pyridoxal phosphate analogs and analysis of electronic absorption spectra

, 1973
In-yu Yang
openalex   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Plasma creatine kinase/aspartate aminotransferase ratio in the diagnosis of acute myocardial infarction. [PDF]

, 1985
P Garcin-Webb, C S Bhagat, John Beilby
openalex   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source