Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. [PDF]
PLoS ONE, 2012 Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6 ...
Mohini S Ghatge +10 more
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Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate
International Journal of Nanomedicine, 2012 A Filipowicz, S WołowiecDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, Rzeszów, PolandBackground: Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as
Filipowicz A, Wołowiec S
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Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults [PDF]
Frontiers in NutritionObjectiveReference intervals (RIs) for vitamin B6 biomarkers remain underexplored in Chinese adults. We aimed to establish age- and sex-specific RIs of pyridoxal 5′-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (PA), and their ratios (PLP/PL, PLP/PA,
Yazhao Mei +14 more
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Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Information processing in the central nervous system relies on chemical synapses where neurotransmitters such as the inhibitory neurotransmitter γ-aminobutyric acid (GABA) are released at presynaptic nerve endings.
Natascha Schaefer +2 more
exaly +2 more sources
DFT, ADMET, molecular docking and molecular dynamics studies of pyridoxal [PDF]
Journal of the Indian Chemical Society, 2023 We report in silico studies of pyridoxal, which is of interest both as a precursor for further functionalization due to the presence of the aldehyde functionality, as well as a bioactive compound.
N. A. Garkusha +4 more
semanticscholar +2 more sources
Correction: Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults [PDF]
Frontiers in NutritionYazhao Mei +14 more
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Stereoselective amino acid synthesis by synergistic photoredox–pyridoxal radical biocatalysis
Science, 2023 Developing synthetically useful enzymatic reactions that are not known in biochemistry and organic chemistry is an important challenge in biocatalysis. Through the synergistic merger of photoredox catalysis and pyridoxal 5′-phosphate (PLP) biocatalysis ...
Lei Cheng +6 more
semanticscholar +1 more source
Journal of Biological Chemistry, 2023 Recently, biallelic variants in PLPBP coding for pyridoxal 5′-phosphate homeostasis protein (PLPHP) were identified as a novel cause of early-onset vitamin B6–dependent epilepsy.
J. Ciapaite +11 more
semanticscholar +1 more source
Oxovanadium(IV) complexes of the pyridoxal Schiff bases: Synthesis, experimental and theoretical characterizations, QTAIM analysis and antioxidant activity [PDF]
Journal of the Serbian Chemical Society, 2020 Two vanadyl complexes of the pyridoxal Schiff bases have been newly synthesized and characterized by several experimental methods, where the 4,4′-[1,4-butanediylbis-[(E)-nitrilomethylidyne])bis[5-hydroxy-6-methyl- -3-pyridinemethanol] and trans-4,4′-[1,2-
Ghorbani Parisa +3 more
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Animals, 2023 Vitamin B6 is an indispensable micronutrient in organisms and is widely distributed in blood, tissues, and organs. Changes in the content and ratio of vitamin B6 can affect the entire physiological condition of the body, so it becomes particularly ...
Rong-Ju Yang +7 more
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