Results 1 to 10 of about 4,224 (156)

Pyridoxamine reduces inflammatory and microcirculatory abnormalities in metabolic dysfunction-associated steatohepatitis and modulates key factors in the hepatic AGE/ALE signaling pathway [PDF]

Frontiers in Physiology
Metabolic dysfunction-associated steatohepatitis (MASH) is an increasing public health concern for which new therapies are urgently needed. As growing evidence suggests that the advanced glycation/lipoxidation end products (AGE/ALE) pathway contribute to
Raquel Rangel Silvares, Beatriz Peres de Araujo, Evelyn Nunes Goulart Da Silva Pereira, Karine Lino Rodrigues, Juliana Magalhães Chaves Barbosa, Juliana Florencio da Silva, Vivian Vieira Dias da Silva, Marjo Van de aarenburg, Jean Scheijen, Kristiaan Wouters, Casper Schalkwijk, Anissa Daliry   +11 more
doaj   +2 more sources

Complexes of Copper and Iron with Pyridoxamine, Ascorbic Acid, and a Model Amadori Compound: Exploring Pyridoxamine’s Secondary Antioxidant Activity

Antioxidants, 2021
The thermodynamic stability of 11 complexes of Cu(II) and 26 complexes of Fe(III) is studied, comprising the ligands pyridoxamine (PM), ascorbic acid (ASC), and a model Amadori compound (AMD).
Nelaine Mora-Díez, Roger Monreal-Corona   +1 more
exaly   +3 more sources

How Does Pyridoxamine Inhibit the Formation of Advanced Glycation End Products? The Role of Its Primary Antioxidant Activity

Antioxidants, 2019
Pyridoxamine, one of the natural forms of vitamin B6, is known to be an effective inhibitor of the formation of advanced glycation end products (AGEs), which are closely related to various human diseases.
Joaquin Ortega-Castro, Bartolome Vilanova Canet, Miquel Adrover   +2 more
exaly   +3 more sources

Advanced glycation end-products exacerbate myocardial ischemia/reperfusion injury by promoting mitochondrial oxidative damage and PANoptosis in diabetes mellitus [PDF]

Redox Biology
Diabetes mellitus exacerbates myocardial ischemia/reperfusion injury (MI/RI), but the underlying mechanisms remain unclear. The present study identifies advanced glycation end-products (AGEs) as a key pathological mediator.
Ji'e Yang, Jian Zhang, Rong Huang, Ke Meng, Jiayu Liang, Jingyi Lin, Jingpu Wang, Yiweng Wang, Yang Gao, Yanan Qu, Shiyu Hu, Jiatian Cao, Hao Su, Feng Zhang, Junbo Ge   +14 more
doaj   +2 more sources

Validation of the Vitamin B₆ Profile (Pyridoxine, Pyridoxal, and Pyridoxamine) Analysis in Rice Consumed in Korea: Effects of Cooking and Variety [PDF]

Foods
Rice, a widely consumed grain, contains various forms of vitamin B6, including pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM). However, limited information exists on their content and distribution in rice.
Minyoung Je, Hui Jin Lee, Jiyeon Chun
doaj   +2 more sources

Case report: Hepatocellular carcinoma in a patient with Pyridoxamine 5-phosphate oxidase (PNPO) deficiency undergoing pyridoxal 5-phosphate (PLP) treatment [PDF]

Molecular Genetics and Metabolism Reports
Pyridoxamine 5-phosphate oxidase (PNPO) deficiency is an autosomal recessive inborn error of metabolism that typically manifests as seizures resistant to conventional anticonvulsants, often presenting in the neonatal period to early infancy.
Jesse Zhen Cheng Lee, Chit Kwong Chow, Cheuk-Wing Fung, Stephen Tak Yau Lui, Suet-Na Sheila Wong   +4 more
doaj   +2 more sources

Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamines and synergistic solvent [PDF]

Nature Communications
Chiral α-aminophosphonate derivatives are recognized as valuable compounds in both medicine and organic chemistry. Biomimetic transamination of α-keto phosphonates represents one of the most efficient strategies for accessing these pharmaceutically ...
Dongchen Cai, Longjie Huang, Zhuochuan Wang, Siqi Liu, Xiao Xiao, Baoguo Zhao   +5 more
doaj   +2 more sources

Pyridoxamine inhibits dopamine-induced α-synuclein oligomerization through scavenging neurotoxic dopamine quinone [PDF]

Scientific Reports
Parkinson’s disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic neurons causing reduced levels of dopamine (DA), and the presence of Lewy bodies, whose main component is fibrillar α-synuclein (α-Syn).
Seon Hwa Lee, Naoya Matsumoto, Akane Terada, Yusuke Hatakawa, Tomoyuki Oe   +4 more
doaj   +2 more sources

Plasma vitamin levels and pathway analysis in boys with autism spectrum disorders [PDF]

Scientific Reports
Abnormal feeding behaviors and inadequate nutrient intake of children with autism spectrum disorder (ASD) have been reported. This study aimed to examine the plasma vitamin status of boys with autism spectrum disorder (ASD) and to analyze the association
Lili Zhang, Jian Ji, Yue Wang, Lei Wang, Ruixuan Zheng, Yunshu Jiang   +5 more
doaj   +2 more sources

Vitamin B6 form produced by Lactobacillus induces metabolic disorder and suppresses multi-pathogenic bacteria [PDF]

Communications Biology
Vitamin B6 comprises six vitamers, pyridoxal, pyridoxine, pyridoxamine, pyridoxal 5′-phosphate (PLP), pyridoxine 5′-phosphate (PNP), and pyridoxamine 5′-phosphate (PMP), recognized for pleiotropic functions in mitigating oxidative stress and modulating ...
Ying Wu, Zhenmin Ling, Liang Peng, Xing Wang, Yue He, Aman Khan, El-Sayed Salama, Sourabh Kulshreshtha, Pu Liu, Xiangkai Li   +9 more
doaj   +2 more sources