Results 1 to 10 of about 5,366 (188)

How Does Pyridoxamine Inhibit the Formation of Advanced Glycation End Products? The Role of Its Primary Antioxidant Activity [PDF]

Antioxidants, 2019
Pyridoxamine, one of the natural forms of vitamin B6, is known to be an effective inhibitor of the formation of advanced glycation end products (AGEs), which are closely related to various human diseases.
Joaquin Ortega-Castro, Bartolome Vilanova Canet, Miquel Adrover   +2 more
exaly   +7 more sources

Pyridoxamine reduces inflammatory and microcirculatory abnormalities in metabolic dysfunction-associated steatohepatitis and modulates key factors in the hepatic AGE/ALE signaling pathway [PDF]

Frontiers in Physiology
Metabolic dysfunction-associated steatohepatitis (MASH) is an increasing public health concern for which new therapies are urgently needed. As growing evidence suggests that the advanced glycation/lipoxidation end products (AGE/ALE) pathway contribute to
Raquel Rangel Silvares, Beatriz Peres de Araujo, Evelyn Nunes Goulart Da Silva Pereira, Karine Lino Rodrigues, Juliana Magalhães Chaves Barbosa, Juliana Florencio da Silva, Vivian Vieira Dias da Silva, Marjo Van de aarenburg, Jean Scheijen, Kristiaan Wouters, Casper Schalkwijk, Anissa Daliry   +11 more
doaj   +2 more sources

Complexes of Copper and Iron with Pyridoxamine, Ascorbic Acid, and a Model Amadori Compound: Exploring Pyridoxamine’s Secondary Antioxidant Activity

Antioxidants, 2021
The thermodynamic stability of 11 complexes of Cu(II) and 26 complexes of Fe(III) is studied, comprising the ligands pyridoxamine (PM), ascorbic acid (ASC), and a model Amadori compound (AMD).
Nelaine Mora-Díez, Roger Monreal-Corona   +1 more
exaly   +3 more sources

Advanced glycation end-products exacerbate myocardial ischemia/reperfusion injury by promoting mitochondrial oxidative damage and PANoptosis in diabetes mellitus [PDF]

Redox Biology
Diabetes mellitus exacerbates myocardial ischemia/reperfusion injury (MI/RI), but the underlying mechanisms remain unclear. The present study identifies advanced glycation end-products (AGEs) as a key pathological mediator.
Ji'e Yang, Jian Zhang, Rong Huang, Ke Meng, Jiayu Liang, Jingyi Lin, Jingpu Wang, Yiweng Wang, Yang Gao, Yanan Qu, Shiyu Hu, Jiatian Cao, Hao Su, Feng Zhang, Junbo Ge   +14 more
doaj   +2 more sources

Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamines and synergistic solvent [PDF]

Nature Communications
Chiral α-aminophosphonate derivatives are recognized as valuable compounds in both medicine and organic chemistry. Biomimetic transamination of α-keto phosphonates represents one of the most efficient strategies for accessing these pharmaceutically ...
Dongchen Cai, Longjie Huang, Zhuochuan Wang, Siqi Liu, Xiao Xiao, Baoguo Zhao   +5 more
doaj   +2 more sources

Case report: Hepatocellular carcinoma in a patient with Pyridoxamine 5-phosphate oxidase (PNPO) deficiency undergoing pyridoxal 5-phosphate (PLP) treatment [PDF]

Molecular Genetics and Metabolism Reports
Pyridoxamine 5-phosphate oxidase (PNPO) deficiency is an autosomal recessive inborn error of metabolism that typically manifests as seizures resistant to conventional anticonvulsants, often presenting in the neonatal period to early infancy.
Jesse Zhen Cheng Lee, Chit Kwong Chow, Cheuk-Wing Fung, Stephen Tak Yau Lui, Suet-Na Sheila Wong   +4 more
doaj   +2 more sources

Validation of the Vitamin B₆ Profile (Pyridoxine, Pyridoxal, and Pyridoxamine) Analysis in Rice Consumed in Korea: Effects of Cooking and Variety [PDF]

Foods
Rice, a widely consumed grain, contains various forms of vitamin B6, including pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM). However, limited information exists on their content and distribution in rice.
Minyoung Je, Hui Jin Lee, Jiyeon Chun
doaj   +2 more sources

Pyridoxamine inhibits dopamine-induced α-synuclein oligomerization through scavenging neurotoxic dopamine quinone [PDF]

Scientific Reports
Parkinson’s disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic neurons causing reduced levels of dopamine (DA), and the presence of Lewy bodies, whose main component is fibrillar α-synuclein (α-Syn).
Seon Hwa Lee, Naoya Matsumoto, Akane Terada, Yusuke Hatakawa, Tomoyuki Oe   +4 more
doaj   +2 more sources

Effect of miR-27b-3p and Nrf2 in human retinal pigment epithelial cell induced by high-glucose [PDF]

International Journal of Ophthalmology, 2023
AIM: To determine whether the microRNA-27b-3p (miR-27b-3p)/NF-E2-related factor 2 (Nrf2) pathway plays a role in human retinal pigment epithelial (hRPE) cell response to high glucose, how miR-27b-3p and Nrf2 expression are regulated, and whether this ...
Qiao-Ling Lai, Ting Xie, Wei-Dong Zheng, Yan Huang   +3 more
doaj   +1 more source

Synthesis of B6 vitamin [PDF]

Hemijska Industrija, 2009
The importance of vitamin B6 has been known since its discovery in the 1940's. Chemical tests, elestrometric titration determinations, and absorption spectrum studies showed that this vitamin exists in three major chemical forms: pyridoxine (an alcohol),
Vučijak Nevena Ž., Petrović Slobodan D., Bezbradica Dejan I., Knežević-Jugović Zorica D., Mijin Dušan Ž.   +4 more
doaj   +1 more source