Results 11 to 20 of about 4,298 (230)

Effect of miR-27b-3p and Nrf2 in human retinal pigment epithelial cell induced by high-glucose [PDF]

International Journal of Ophthalmology, 2023
AIM: To determine whether the microRNA-27b-3p (miR-27b-3p)/NF-E2-related factor 2 (Nrf2) pathway plays a role in human retinal pigment epithelial (hRPE) cell response to high glucose, how miR-27b-3p and Nrf2 expression are regulated, and whether this ...
Qiao-Ling Lai, Ting Xie, Wei-Dong Zheng, Yan Huang   +3 more
doaj   +1 more source

Synthesis of B6 vitamin [PDF]

Hemijska Industrija, 2009
The importance of vitamin B6 has been known since its discovery in the 1940's. Chemical tests, elestrometric titration determinations, and absorption spectrum studies showed that this vitamin exists in three major chemical forms: pyridoxine (an alcohol),
Vučijak Nevena Ž., Petrović Slobodan D., Bezbradica Dejan I., Knežević-Jugović Zorica D., Mijin Dušan Ž.   +4 more
doaj   +1 more source

Pyridoxamine alleviates mechanical allodynia by suppressing the spinal receptor for advanced glycation end product-nuclear factor-B/extracellular signal-regulated kinase signaling pathway in diabetic rats

Molecular Pain, 2020
Diabetic neuropathic pain is a common complication of diabetes mellitus and requires a substantial amount of societal resources. Pyridoxamine is an inhibitor of advanced glycation and lipoxidation end products.
Xin Zhang, Li Xu, Weiyun Chen, Xuerong Yu, Le Shen, Yuguang Huang   +5 more
doaj   +1 more source

B6 vitamers as generators and scavengers of reactive oxygen species

Journal of Photochemistry and Photobiology, 2021
B6 vitamers are important natural compounds for human life, principally for amino acid metabolism, and have been reported as potent scavenger molecules of both endogenous and exogenous reactive oxygen species (ROS).
Italo Rodrigo Calori, Luiza Araújo Gusmão, Antonio Claudio Tedesco   +2 more
doaj   +1 more source

Scientific opinion on the tolerable upper intake level for vitamin B6

EFSA Journal, 2023
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for vitamin B6.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan deHenauw, Karen‐Ildico Hirsch‐Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Susan Fairweather‐Tait, Misha Vrolijk, Lucia Fabiani, Ariane Titz, Androniki Naska   +20 more
doaj   +1 more source

Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits

Antioxidants, 2021
Recent studies have shown that carbonyl stress is a causative factor of schizophrenia, categorized as carbonyl stress-related schizophrenia (CS-SCZ).
Shin Koike, Kazuya Toriumi, Sakura Kasahara, Yosuke Kibune, Yo-ichi Ishida, Takashi Dan, Toshio Miyata, Makoto Arai, Yuki Ogasawara   +8 more
doaj   +1 more source

Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease

Haematologica, 2019
Adherent neutrophils on vascular endothelium positively contribute to cell-cell aggregation and vaso-occlusion in sickle cell disease. In the present study, we demonstrated that pyridoxamine, a derivative of vitamin B6, might be a therapeutic agent to ...
Jing Li, Si-Yeon Jeong, Bei Xiong, Alan Tseng, Andrew B. Mahon, Steven Isaacman, Victor R. Gordeuk, Jaehyung Cho   +7 more
doaj   +1 more source

Prebiotic Synthesis of Aspartate Using Life’s Metabolism as a Guide

Life, 2023
A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite
Stuart A. Harrison, William L. Webb, Hanadi Rammu, Nick Lane   +3 more
doaj   +1 more source

Absorption and Metabolism of Pyridoxamine in Mice II. Transformation of Pyridoxamine to Pyridoxal in Intestinal Tissues.

Journal of Nutritional Science and Vitaminology, 1992
The absorption of pyridoxamine from the intestine of the mouse was studied in whole animals. [3H]Pyridoxamine was orally administered and the distribution of isotope between the six recognized forms of vitamin B6 was determined in portal blood after the administration.
T, Sakurai, T, Asakura, A, Mizuno, M, Matsuda   +3 more
openaire   +4 more sources

Reduction of Methylglyoxal-Induced Glycation by Pyridoxamine Improves Adipose Tissue Microvascular Lesions

Journal of Diabetes Research, 2013
Background and Aims. Adipose tissue dysfunction results from many factors, including glycation-induced microvascular damages. We tested the usefulness of inhibiting methylglyoxal-induced glycation to adipose tissue microvasculature in this work, using ...
Tiago Rodrigues, Paulo Matafome, Daniela Santos-Silva, Cristina Sena, Raquel Seiça   +4 more
doaj   +1 more source