Results 31 to 40 of about 4,298 (230)

Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells

Cells
Doxorubicin (DOX) is commonly used in cancer treatment but associated with cardiotoxicity. Pyridoxamine (PM), a vitamin B6 derivative, could be a cardioprotectant.
Sibren Haesen, Eline Verghote, Ellen Heeren, Esther Wolfs, Dorien Deluyker, Virginie Bito   +5 more
doaj   +1 more source

Dietary Reference Values for vitamin B6

EFSA Journal, 2016
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives Dietary Reference Values (DRVs) for vitamin B6. The Panel considers that plasma pyridoxal 5′‐phosphate (PLP) concentration is the
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

Biosynthesis of food constituents: Vitamins. 2. Water-soluble vitamins: Part 1 - a review

Czech Journal of Food Sciences, 2007
This review article gives a survey of the generally accepted biosynthetic pathways that lead to water-soluble vitamins in microorganisms, plants and some animals.
Jan Velíšek, Karel Cejpek
doaj   +1 more source

The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. [PDF]

PLoS ONE, 2013
BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.
Monique Albersen, Marjolein Bosma, Nine V V A M Knoers, Berna H B de Ruiter, Eugène F Diekman, Jessica de Ruijter, Wouter F Visser, Tom J de Koning, Nanda M Verhoeven-Duif   +8 more
doaj   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Impact of Dissolved Oxygen during UV-Irradiation on the Chemical Composition and Function of CHO Cell Culture Media.

PLoS ONE, 2016
Ultraviolet (UV) irradiation is advantageous as a sterilization technique in the biopharmaceutical industry since it is capable of targeting non-enveloped viruses that are typically challenging to destroy, as well as smaller viruses that can be difficult
Sarah M Meunier, Biljana Todorovic, Emma V Dare, Afroza Begum, Simon Guillemette, Andrew Wenger, Priyanka Saxena, J Larry Campbell, Michael Sasges, Marc G Aucoin   +9 more
doaj   +1 more source

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

Animal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu, Yiwei Sun, Kun Cai, Pingli He, Gang Lin, Zengkai Qi, Hu Liu, Junshu Yan, Ning Ma   +8 more
wiley   +1 more source

Key Challenges for Commercializing Perovskite–Silicon Tandem Solar Cells

Carbon Energy, EarlyView.
This review discusses the scientific and technological challenges in advancing perovskite–silicon tandem solar cells (PSTSCs) from lab‐scale to commercial viability, focusing on long‐term stability, scalability, and economic feasibility. Key issues include intrinsic and extrinsic degradation factors, installation conditions, environmental impacts, and ...
Bilal Mehmood, Yuanyuan Qin, Abdul Sattar, Rabeea Eman, Faheem Abbas, Shan Wu, Yipeng Xu, Xu Zheng, Jiangying Lu, Wei Jiang, Jiankai Liu, Shudi Lu, Shizhong Yue, Zhijie Wang, Kong Liu, Xiaopeng Zheng, Shengchun Qu   +16 more
wiley   +1 more source

Comprehensive Peptide Profiling Reveals the Influence of Streptococcus Thermophilus, Lactobacillus Delbrueckii Subsp. bulgaricus, and Endogenous Milk Proteases on the Hydrolysis of Milk Proteins During Early‐Stage Lactic Acid Fermentation

ChemFoodChem, EarlyView.
Untargeted peptide profiling investigates how S. thermophilus, Lb. bulgaricus, and endogenous milk enzymes impact proteolysis during early‐stage milk fermentation. ≥ 3000 identified peptides show the strongest influence of LB on the peptide profile and number of bioactive peptides. Shorter peptides are mostly formed by LB and hydrolyzed by ST.
Eva Beck, Lena Riedinger, Sevim Dalabasmaz, Joachim Stützer, Luisa Bähr, Rohtraud Pichner, Monika Pischetsrieder   +6 more
wiley   +1 more source