4-Pyridoxic Acid in the Spent Dialysate: Contribution to Fluorescence and Optical Monitoring. [PDF]
PLoS ONE, 2016 In this work we estimated the contribution of the fluorescence of 4-pyridoxic acid (4-PA) to the total fluorescence of spent dialysate with the aim of evaluating the on-line monitoring of removal of this vitamin B-6 metabolite from the blood of patients ...
Sigrid Kalle +5 more
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4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores [PDF]
Diagnostics, 2019 Background: Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk ...
Rima Obeid +2 more
doaj +4 more sources
A one-step NIST traceable HPLC method for quantitation of vitamin B6 and 4-pyridoxic acid in human plasma [PDF]
Practical Laboratory Medicine, 2020 Objectives: Vitamin B6 deficiency is associated with a wide spectrum of clinical syndromes. While vitamin B6 status is primarily assessed by measuring the biologically active form of the vitamin, pyridoxal 5-phosphate (PLP), concurrent measurement of the
Xiaochun Zhang +2 more
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PLP catabolism: Identification of the 4-pyridoxic acid dehydrogenase gene in Mesorhizobium loti MAFF303099 [PDF]
Bioorganic Chemistry, 2007 The function of the mlr6793 gene from Mesorhizobium loti MAFF303099 has been identified. This gene encodes 4-pyridoxic acid dehydrogenase, an enzyme involved in the catabolism of PLP (Vitamin B6). This enzyme was overexpressed in Escherichia coli and characterized.
Tathagata Mukherjee +2 more
exaly +5 more sources
Integrated metagenomic and metabolomic profiling of spontaneous preterm birth in Chinese women [PDF]
Frontiers in MicrobiologyBackgroundSpontaneous preterm birth (sPTB) remains a major cause of neonatal morbidity and mortality. We used integrated metagenomics and untargeted metabolomics to identify vaginal microbial and host metabolic signatures associated with sPTB in Chinese ...
Heng Xue +8 more
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Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults [PDF]
Frontiers in NutritionObjectiveReference intervals (RIs) for vitamin B6 biomarkers remain underexplored in Chinese adults. We aimed to establish age- and sex-specific RIs of pyridoxal 5′-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (PA), and their ratios (PLP/PL, PLP/PA,
Yazhao Mei +14 more
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Maternal metabolic signatures at early gestation associated with birth weight and neurodevelopment in early childhood [PDF]
Communications MedicineBackground Emerging evidence suggests that maternal factors during pregnancy can exert effects on offspring. However, the underlying metabolic associations remain insufficiently understood.
Jun Yang +8 more
doaj +2 more sources
Rabbit Does as a Model for Studying Plasma Metabolomic Adaptations Across Reproductive Stages: Insights from Parturition to Weaning [PDF]
Veterinary SciencesMetabolomics is increasingly applied in veterinary molecular biology to investigate physiological adaptations in animals. In this study, rabbit does were used as a model to explore plasma metabolomic changes associated with key reproductive stages ...
Jorge Mateo-López +6 more
doaj +2 more sources
Exploratory Analysis of Gut Microbiome and Metabolic Profile Changes Following Lenvatinib and Anti-PD-1 Combination Therapy in Liver Cancer [PDF]
MetabolitesBackground/Objectives: Lenvatinib combined with anti-PD-1 therapy has shown promise in the treatment of hepatocellular carcinoma (HCC). The study evaluates changes in gut microbiota (GM) and metabolites during HCC treatment with lenvatinib combined with ...
Rui Zhong +11 more
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Association between vitamin B6 status and eczema in children and adolescents: results from the NHANES database [PDF]
Frontiers in PediatricsAimThere are few studies investigating the relationship between vitamin B6 status and the odds of eczema in children and adolescents. Hereby, this study aims to explore the association between vitamin B6 status and eczema in children and adolescents ...
Guimei Du, Xinghui Li
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