Results 21 to 30 of about 346,502 (202)

Metabolic dynamics and stage-specific biomarkers in chronic HBV infection: a metabolomics study [PDF]

BMC Gastroenterology
Objective This study was aimed to identify and investigate changes in serum metabolites across the natural progression of chronic hepatitis B (CHB) patients, discover differential metabolites and metabolic pathways in different disease phases, and ...
Lizhi Liu, Zifei Zhu, Wenwen Jin, Xi Su, Zhonghua Deng, Cunyan Li   +5 more
doaj   +2 more sources

Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner [PDF]

Gut Microbes
Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic stress ...
Wenxiang Qing, Huimin Chen, Xin Ma, Jie Chen, Yuan Le, Hui Chen, Jianhua Tong, Kaiming Duan, Daqing Ma, Wen Ouyang, Jianbin Tong   +10 more
doaj   +2 more sources

Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer [PDF]

Cancer & Metabolism
Background Malignant ascites is a common complication of advanced ovarian cancer (OC) and gastrointestinal cancer (GI), significantly impacting metastasis, quality of life, and survival.
Sisi Deng, Wooyong Kim, Kefan Cheng, Qianlu Yang, Yogesh Singh, Gyuntae Bae, Nicolas Bézière, Lukas Mager, Stefan Kommoss, Jannik Sprengel, Christoph Trautwein   +10 more
doaj   +2 more sources

Gut microbiome and metabolome profiles in renal allograft rejection from multiomics integration [PDF]

mSystems
The gut microbiome and metabolome play crucial roles in renal allograft rejection progression. Integrated multiomics analyses may provide a comprehensive understanding of specific underlying mechanisms, which remain elusive.
Xing Dai, Yu Cao, Lin Li, Yue-Xin Gao, Jian-Xi Wang, Yao-Juan Liu, Ting-Ting Ma, Jian-Ming Zheng, Pan-Pan Zhan, Zhong-Yang Shen   +9 more
doaj   +2 more sources

Heat Stress Affects Faecal Microbial and Metabolic Alterations of Rabbits

Frontiers in Microbiology, 2022
Heat stress can impair the rabbit immune system, induce oxidative stress, and cause many complications. These diseases are characterized by metabolic disorders, but the underlying mechanism is unknown.
Xue Bai, Yu Shi, Lipeng Tang, Li Chen, Huimei Fan, Haoding Wang, Jie Wang, Xianbo Jia, Shiyi Chen, Songjia Lai   +9 more
doaj   +1 more source

Elevated plasma 4-pyridoxic acid in renal insufficiency [PDF]

The American Journal of Clinical Nutrition, 2002
Renal insufficiency is associated with altered vitamin B-6 metabolism. We have observed high concentrations of 4-pyridoxic acid, the major catabolite of vitamin B-6 metabolism, in plasma during renal insufficiency.The objective was to evaluate the renal handling of 4-pyridoxic acid and the effects of renal dysfunction on vitamin B-6 metabolism.We ...
Stephen P, Coburn, Robert D, Reynolds, J Dennis, Mahuren, Wayne E, Schaltenbrand, Yao, Wang, Karen L, Ericson, Michael P, Whyte, Yvonne M, Zubovic, Paula J, Ziegler, David L, Costill, William J, Fink, David R, Pearson, Thomas A, Pauly, K George, Thampy, Jacobo, Wortsman   +14 more
openaire   +2 more sources

Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B ...
Kambiz Gilany, Ashraf Mohamadkhani, Saeed Chashmniam, Parisa Shahnazari, Mehdi Amini, Babak Arjmand, Reza Malekzadeh, Bibi Fatemeh Nobakht Motlagh Ghoochani   +7 more
doaj   +1 more source

Urinary excretion of pyridoxine and 4‐pyridoxic acid in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1964
AbstractSeven patients with active rheumatoid arthritis excreted significantly less pyridoxine in the urine than controls when patient‐control pairs were fed identical constant diets while receiving no drugs. After a 10 mg. dose of pyridoxine hydrochloride, change in objectively measured stiffness appeared to be inversely related to change in urinary ...
A B, MCKUSICK, R W, SHERWIN, L G, JONES, J M, HSU   +3 more
openaire   +2 more sources

Inulin and Chinese Gallotannin Affect Meat Quality and Lipid Metabolism on Hu Sheep

Animals, 2022
The aim of this study was to investigate the impacts of inulin and Chinese gallotannin on the meat fatty acids and urinary metabolites in sheep. Twenty-four healthy (25.80 ± 3.85 kg) weaned Hu lambs of approximately 4.5 months old were equally divided ...
Zhaohua He, Long Cheng, Shaobin Li, Qiaoling Liu, Xue Liang, Jiang Hu, Jiqing Wang, Xiu Liu, Fangfang Zhao   +8 more
doaj   +1 more source

Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke

BMC Neurology, 2021
Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation associated with sedentary ...
Katinka Nordheim Alme, Arve Ulvik, Torunn Askim, Jörg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Næss, Ingvild Saltvedt, Per-Magne Ueland, Anne-Brita Knapskog   +9 more
doaj   +1 more source