Results 1 to 10 of about 39,911 (165)

Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6–dependent Epilepsy Than Pyridoxal 5′-Phosphate [PDF]

Pediatric Neurology, 2020
Background We aimed to demonstrate the biochemical characteristics of vitamin B6–dependent epilepsy, with a particular focus on pyridoxal 5′-phosphate and pyridoxal in the cerebrospinal fluid. Methods Using our laboratory database, we identified patients
Tomoyuki Akiyama, KŌSEI Hasegawa, Yuri Dowa   +2 more
exaly   +3 more sources

A vibrational analysis of pyridoxal 5′-phosphate derivatives: pyridoxal 5′-Phosphate-isopropylamine and pyridoxal 5′-phosphate-(S)-1-phenylethylamine [PDF]

J Phys Chem B
The external aldimine, a pivotal Schiff base intermediate in pyridoxal 5′-phosphate (PLP)-dependent enzyme-catalyzed reactions, plays a central mechanistic role in the ω-transamination pathway used for the synthesis of chiral amines in pharmaceutical ...
Waddell, Lachlan J. N., Collier, Paul, Parker, Stewart F., Sutherland, Andrew, Grainger, Damian, Dosanjh, Ramandeep S., Tailor, Sanita B., Pushpanath, Ahir, York, Andrew P. E., Johnson, Timothy, Hyde, Timothy, Lennon, David   +11 more
core   +2 more sources

SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation [PDF]

Nat Commun
Many essential proteins require pyridoxal 5’-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and ...
Sarah M. Chang, David M. Sabatini, Jason Yang, Shveta Bathla, Grzegorz Sienski, Charles H. Adelmann, Caroline A. Lewis, Matthew G. Vander Heiden, Preston Ge, Angus C. Nairn, Izabella A. Pena, Nora Kory, Myriam Heiman, Isabella H. Witham, Samuel Block, Jeffrey S. Shi, Heather R. Keys   +16 more
core   +2 more sources

Discovery and Characterization of Pyridoxal 5’-Phosphate-Dependent Cycloleucine Synthases [PDF]

J Am Chem Soc
Pyridoxal 5’-phosphate (PLP)-dependent enzymes are the most versatile biocatalysts for synthesizing non proteinogenic amino acids. a,a-disubstituted quaternary amino acids, such as 1-amino-1-cyclopentanecarboxylic acid (cycloleucine), are useful building
David A., Delgadillo, Kaushik , Seshadri, Lygia S., de Moraes, Kyle K., Nagasawa, Hosea M., Nelson, Masao, Ohashi, Samuel , Johnson, Yi, Tang, Abner N. D., Abad, Mengting, Liu   +9 more
core   +2 more sources

Pyridoxal 5'-phosphate biosynthesis by pyridox-(am)-ine 5'-phosphate oxidase: species-specific features [PDF]

Int J Mol Sci
Enzymes reliant on pyridoxal 5′-phosphate (PLP), the metabolically active form of vitamin B6, hold significant importance in both biology and medicine.
Medina, Milagros, Milagros Medina, Novo, Nerea, Maribel Rivero, Rivero, Maribel, Nerea Novo   +5 more
core   +2 more sources

On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5′-phosphate

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2015
Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, plays a crucial role in several cellular processes. In most organisms, PLP is recycled from nutrients and degraded B6-enzymes in a salvage pathway that involves pyridoxal kinase ...
Martino L Di Salvo, Isabel Noguès, Angela Tramonti   +2 more
exaly   +2 more sources

A novel phosphatase specific for pyridoxal 5′-phosphate in an aerobic photosynthetic bacterium, Erythrobacter sp. OCh 114 [PDF]

FEMS Microbiology Letters, 1988
Abstract An acid phosphatase highly spcific for pyridoxal 5′-phosphate (PLP) was found and partially purified from the aerobic photosynthetic bacterium, Erythrobacter sp. OCh 114. The enzyme showed a pH optimum at 5.5; its activity was stimulated by magnesium ions.
null Michio Doi, null Yuzo Shioi
openaire   +1 more source

High catalytic activity of alanine racemase from psychrophilicBacillus psychrosaccharolyticusat high temperatures in the presence of pyridoxal 5′-phosphate [PDF]

FEMS Microbiology Letters, 2000
We examined the effect of the pyridoxal 5'-phosphate (PLP) cofactor on the activity and stability of the psychrophilic alanine racemase, having a high catalytic activity at low temperature, from Bacillus psychrosaccharolyticus at high temperatures. The decrease in the enzyme activity at incubation temperatures over 40 degrees C was consistent with the ...
Y, Okubo, K, Yokoigawa, N, Esaki, K, Soda, H, Misono   +4 more
openaire   +2 more sources

4-Phospho-hydroxy-l-threonine is an obligatory intermediate in pyridoxal 5′-phosphate coenzyme biosynthesis inEscherichia coliK-12 [PDF]

FEMS Microbiology Letters, 1996
We show that thrB-encoded homoserine kinase is required for growth of Escherichia coli K-12 pdxB mutants on minimal glucose medium supplemented with 4-hydroxy-L-threonine (synonym, 3-hydroxyhomoserine) or D-glycolaldehyde. This result is consistent with a model in which 4-phospho-hydroxy-L-threonine (synonym, 3-hydroxyhomoserine phosphate), rather than
G, Zhao, M E, Winkler
openaire   +2 more sources

Enzyme-Independent Interaction of Pyridoxal-5’-Phosphate with Cysteine

, 2022
Pyridoxal-5′-phosphate (PLP), commonly known as Vitamin B6, is a versatile co-factor that assists in different types of enzymatic reactions. PLP has also been reported to react with substrates and catalyze some of these reactions independent of enzymes ...
Vijay, Krishna, Cindy, Chen, Prajakatta, Mulay   +2 more
core   +1 more source