Results 1 to 10 of about 39,888 (206)

A vibrational analysis of pyridoxal 5′-phosphate derivatives: pyridoxal 5′-Phosphate-isopropylamine and pyridoxal 5′-phosphate-(S)-1-phenylethylamine [PDF]

The Journal of Physical Chemistry B
The external aldimine, a pivotal Schiff base intermediate in pyridoxal 5′-phosphate (PLP)-dependent enzyme-catalyzed reactions, plays a central mechanistic role in the ω-transamination pathway used for the synthesis of chiral amines in pharmaceutical ...
Waddell, Lachlan J. N., Collier, Paul, Parker, Stewart F., Sutherland, Andrew, Grainger, Damian, Dosanjh, Ramandeep S., Tailor, Sanita B., Pushpanath, Ahir, York, Andrew P. E., Johnson, Timothy, Hyde, Timothy, Lennon, David   +11 more
core   +4 more sources

On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5′-phosphate

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2015
Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, plays a crucial role in several cellular processes. In most organisms, PLP is recycled from nutrients and degraded B6-enzymes in a salvage pathway that involves pyridoxal kinase ...
Martino L Di Salvo, Isabel Noguès, Angela Tramonti   +2 more
exaly   +4 more sources

Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6–dependent Epilepsy Than Pyridoxal 5′-Phosphate [PDF]

Pediatric Neurology, 2020
Background We aimed to demonstrate the biochemical characteristics of vitamin B6–dependent epilepsy, with a particular focus on pyridoxal 5′-phosphate and pyridoxal in the cerebrospinal fluid. Methods Using our laboratory database, we identified patients
Tomoyuki Akiyama, KŌSEI Hasegawa, Yuri Dowa   +2 more
exaly   +3 more sources

Pyridoxal phosphate: biosynthesis and catabolism

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011
Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the ...
Jeremiah Hanes, Ivo Tews, Ealick, Steven E., Tathagata Mukherjee, Mukherjee, Tathagata, Tadhg P. Begley, Tews, Ivo, Hanes, Jeremiah, Steven E. Ealick, Begley, Tadhg P.   +9 more
core   +3 more sources

Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate

International Journal of Nanomedicine, 2012
A Filipowicz, S WołowiecDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, Rzeszów, PolandBackground: Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as
Filipowicz A, Wołowiec S
core   +6 more sources

Enzyme-Independent Interaction of Pyridoxal-5’-Phosphate with Cysteine

, 2022
Pyridoxal-5′-phosphate (PLP), commonly known as Vitamin B6, is a versatile co-factor that assists in different types of enzymatic reactions. PLP has also been reported to react with substrates and catalyze some of these reactions independent of enzymes ...
Vijay, Krishna, Cindy, Chen, Prajakatta, Mulay   +2 more
core   +1 more source

Metal binding to pyridoxal derivatives. An NMR study of the interaction of Eu(III) with pyridoxal phosphate and pyridoxamine phosphate [PDF]

, 1979
The solution conformations of pyridoxal-5′-phosphate and pyridoxamine-5′-phosphate have been investigated using Eu(III) as a nuclear magnetic resonance shift probe.
Ramakrishnan, C., Rao, B. N. Narasinga, Balaram, P.   +2 more
core   +2 more sources

Biochemical and Proteomic Studies of Human Pyridoxal 5′-Phosphate-Binding Protein (PLPBP)

, 2019
The pyridoxal 5′-phosphate-binding protein (PLPBP) is an evolutionarily conserved protein linked to pyridoxal 5′-phosphate-binding. Although mutations in PLPBP were shown to cause vitamin B6-dependent epilepsy, its cellular role and function remain ...
Anja Fux (3740869), Stephan A. Sieber (1473775)   +1 more
core   +3 more sources

Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5′-phosphate-binding protein YggS [PDF]

, 2016
Escherichia coli YggS is a highly conserved pyridoxal 5′-phosphate (PLP)-binding protein whose biochemical function is currently unknown. A previous study with a yggS-deficient E.
Ito, Tomokazu, Yamauchi, Ayako, Hemmi, Hisashi, Yoshimura, Tohru   +3 more
core   +1 more source

Assembly of the eukaryotic PLP-synthase complex from plasmodium and activation of the Pdx1 enzyme

, 2012
Biosynthesis of vitamins is fundamental to malaria parasites. Plasmodia synthesize the active form of vitamin B6 (pyridoxal 5-phosphate, PLP) using a PLP synthase complex.
Böttcher, Bettina, Derrer, Bianca, Windeisen, Volker, Hipp, Katharina, Tews, Ivo, Sinning, Irmgard, Kappes, Barbara, Boettcher, Bettina, Gengenbacher, Martin, Guedez, Gabriela   +9 more
core   +1 more source