Results 1 to 10 of about 805,935 (191)

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. [PDF]

Cell Metab, 2018
SUMMARY Kidney cancer, one of the ten most prevalent malignancies in the world, has exhibited increased incidence over the last decade. The most common subtype is “clear cell” renal cell carcinoma (ccRCC), which features consistent metabolic ...
Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC.   +18 more
europepmc   +2 more sources

Comparative Proteomic Analysis for a Putative Pyridoxal Phosphate-Dependent Aminotransferase Required for Virulence in [PDF]

The Plant Pathology Journal, 2021
Acidovorax citrulli (Ac) is the causative agent of bacterial fruit blotch disease in watermelon. Since resistant cultivars have not yet been developed, the virulence factors/mechanisms of Ac need to be characterized. This study reports the functions of a
Jongchan Lee, Lynn Heo, Sang-Wook Han
doaj   +2 more sources

Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics. [PDF]

Nat Chem, 2018
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based
Hoegl A, Nodwell MB, Kirsch VC, Bach NC, Pfanzelt M, Stahl M, Schneider S, Sieber SA.   +7 more
europepmc   +2 more sources

Pyridoxal Phosphate [PDF]

Reactions Weekly, 2020
P.S. Sears
semanticscholar   +5 more sources

Proteomic and Phenotypic Analyses of a Putative YggS Family Pyridoxal Phosphate-Dependent Enzyme in Acidovorax citrulli [PDF]

The Plant Pathology Journal, 2023
Acidovorax citrulli (Ac) is a phytopathogenic bacterium that causes bacterial fruit blotch (BFB) in cucurbit crops, including watermelon. However, there are no effective methods to control this disease.
Lynn Heo, Yongmin Cho, Junhyeok Choi, Jeongwook Lee, Yoobin Han, Sang-Wook Han   +5 more
doaj   +2 more sources

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. [PDF]

PLoS ONE, 2012
Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6 ...
Mohini S Ghatge, Roberto Contestabile, Martino L di Salvo, Jigar V Desai, Amit K Gandhi, Christina M Camara, Rita Florio, Isabel N González, Alessia Parroni, Verne Schirch, Martin K Safo   +10 more
doaj   +2 more sources

Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme

Nature Communications, 2017
Pyridoxal 5’-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, among them aspartate aminotransferase. Here the authors use neutron crystallography, which allows the visualization of the positions of hydrogen atoms, and computation to ...
Steven Dajnowicz, Ryne C. Johnston, Jerry M. Parks, Matthew P. Blakeley, David A. Keen, Kevin L. Weiss, Oksana Gerlits, Andrey Kovalevsky, Timothy C. Mueser   +8 more
doaj   +2 more sources

Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate

International Journal of Nanomedicine, 2012
A Filipowicz, S WołowiecDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, Rzeszów, PolandBackground: Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as
Filipowicz A, Wołowiec S
doaj   +5 more sources

A Vibrational Analysis of Pyridoxal 5'-Phosphate Derivatives: Pyridoxal 5'-Phosphate-isopropylamine and Pyridoxal 5'-Phosphate-(<i>S</i>)-1-phenylethylamine. [PDF]

J Phys Chem B
The external aldimine, a pivotal Schiff base intermediate in pyridoxal 5'-phosphate (PLP)-dependent enzyme-catalyzed reactions, plays a central mechanistic role in the ω-transamination pathway used for the synthesis of chiral amines in pharmaceutical production.
Dosanjh RS, Parker SF, Collier P, Pushpanath A, York APE, Grainger D, Tailor SB, Johnson T, Hyde T, Waddell LJN, Sutherland A, Lennon D.   +11 more
europepmc   +3 more sources

Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B₆-Dependent Epilepsy. [PDF]

Am J Hum Genet, 2016
Darin N, Reid E, Prunetti L, Samuelsson L, Husain RA, Wilson M, El Yacoubi B, Footitt E, Chong WK, Wilson LC, Prunty H, Pope S, Heales S, Lascelles K, Champion M, Wassmer E, Veggiotti P, de Crécy-Lagard V, Mills PB, Clayton PT.   +19 more
europepmc   +2 more sources