Results 11 to 20 of about 805,988 (244)

Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation

Nutrition Reviews, 2013
Per Magne Ueland, Jacob Selhub, Paul Ligi   +2 more
exaly   +2 more sources

Maintenance of cellular vitamin B6 levels and mitochondrial oxidative function depend on pyridoxal 5′-phosphate homeostasis protein

Journal of Biological Chemistry, 2023
Recently, biallelic variants in PLPBP coding for pyridoxal 5′-phosphate homeostasis protein (PLPHP) were identified as a novel cause of early-onset vitamin B6–dependent epilepsy.
J. Ciapaite, C. V. van Roermund, M. Bosma, J. Gerrits, S. Houten, L. Ijlst, H. Waterham, C. V. van Karnebeek, R. Wanders, F. Zwartkruis, J. Jans, N. Verhoeven-Duif   +11 more
semanticscholar   +1 more source

Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry. [PDF]

PLoS ONE, 2015
Vitamin B1 (thiamine-diphosphate) and B6 (pyridoxal-5'phosphate) are micronutrients. Analysis of these micronutrients is important to diagnose potential deficiency which often occurs in elderly people due to malnutrition, in severe alcoholism and in ...
Johan Puts, Monique de Groot, Martin Haex, Bernadette Jakobs   +3 more
doaj   +1 more source

Vitamin B6 Acquisition and Metabolism in Schistosoma mansoni

Frontiers in Immunology, 2021
Schistosomes are parasitic platyhelminths that currently infect >200 million people globally. The adult worms can live within the vasculature of their hosts for many years where they acquire all nutrients necessary for their survival and growth.
Akram A. Da’dara, Manal Elzoheiry, Manal Elzoheiry, Samar N. El-Beshbishi, Patrick J. Skelly   +4 more
doaj   +1 more source

Emergence of oxygen‐ and pyridoxal phosphate‐dependent reactions

The FEBS Journal, 2020
Pyridoxal 5′‐phosphate (PLP) is an organic cofactor employed by ~ 4% of enzymes. The structure of the PLP cofactor allows for the stabilization of carbanions through resonance.
E. Hoffarth, Kristina W Rothchild, K. Ryan   +2 more
semanticscholar   +1 more source

SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2019
Pyridoxal 5′-phosphate (the active form of vitamin B6) is a cofactor that is important for a broad number of biochemical reactions and is essential for all forms of life.
Michael D. Paxhia, Diana M. Downs
doaj   +1 more source

Stereoselective amino acid synthesis by synergistic photoredox–pyridoxal radical biocatalysis

Science, 2023
Developing synthetically useful enzymatic reactions that are not known in biochemistry and organic chemistry is an important challenge in biocatalysis. Through the synergistic merger of photoredox catalysis and pyridoxal 5′-phosphate (PLP) biocatalysis ...
Lei Cheng, Dian Li, Binh Khanh Mai, Zhiyu Bo, Lida Cheng, P. Liu, Yang Yang   +6 more
semanticscholar   +1 more source

Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5′-phosphate as the inhibitor

Journal of Lipid Research, 2006
Peroxidized phospholipid-mediated cytotoxity is involved in the pathophysiology of a number of diseases [i.e., the abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) found in the plasma of type 2 diabetic patients]. The PCOOH accumulation may
Ohki Higuchi, Kiyotaka Nakagawa, Tsuyoshi Tsuzuki, Toshihide Suzuki, Shinichi Oikawa, Teruo Miyazawa   +5 more
doaj   +1 more source

Significantly Elevated Levels of Plasma Nicotinamide, Pyridoxal, and Pyridoxamine Phosphate Levels in Obese Emirati Population: A Cross-Sectional Study

Molecules, 2020
Water-soluble vitamins like B3 (nicotinamide), B6 (pyridoxine), and B9 (folic acid) are of utmost importance in human health and disease, as they are involved in numerous critical metabolic reactions. Not surprisingly, deficiencies of these vitamins have
Ghada Rashad Ibrahim, Iltaf Shah, Salah Gariballa, Javed Yasin, James Barker, Syed Salman Ashraf   +5 more
doaj   +1 more source

The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. [PDF]

PLoS ONE, 2013
BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.
Monique Albersen, Marjolein Bosma, Nine V V A M Knoers, Berna H B de Ruiter, Eugène F Diekman, Jessica de Ruijter, Wouter F Visser, Tom J de Koning, Nanda M Verhoeven-Duif   +8 more
doaj   +1 more source