Results 11 to 20 of about 404,528 (235)

SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation

Nature Communications
Many essential proteins require pyridoxal 5’-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and ...
Izabella A. Pena, Jeffrey S. Shi, Sarah M. Chang, Jason Yang, Samuel Block, Charles H. Adelmann, Heather R. Keys, Preston Ge, Shveta Bathla, Isabella H. Witham, Grzegorz Sienski, Angus C. Nairn, David M. Sabatini, Caroline A. Lewis, Nora Kory, Matthew G. Vander Heiden, Myriam Heiman   +16 more
doaj   +2 more sources

Pyridoxal Phosphate vs Pyridoxine for Intractable Seizures

Pediatric Neurology Briefs, 2005
The efficacy of pyridoxal phosphate (PLP) compared to pyridoxine (PN) in the control of idiopathic intractable epilepsy was studied in 94 children, aged 8 months to 15 years, at the National Taiwan University Hospital, Taipei, Taiwan.
J Gordon Millichap
doaj   +2 more sources

A Vibrational Analysis of Pyridoxal 5′-Phosphate Derivatives: Pyridoxal 5′-Phosphate-isopropylamine and Pyridoxal 5′-Phosphate-( S )-1-phenylethylamine

The Journal of Physical Chemistry B
The external aldimine, a pivotal Schiff base intermediate in pyridoxal 5'-phosphate (PLP)-dependent enzyme-catalyzed reactions, plays a central mechanistic role in the ω-transamination pathway used for the synthesis of chiral amines in pharmaceutical production.
Ramandeep S. Dosanjh, Stewart F. Parker, Paul Collier, Ahir Pushpanath, Andrew P. E. York, Damian Grainger, Sanita B. Tailor, Timothy Johnson, Timothy Hyde, Lachlan J. N. Waddell, Andrew Sutherland, David Lennon   +11 more
openaire   +3 more sources

PYRIDOXAL-5'-PHOSPHATE INHIBITION OF PLATELET FUNCTION.

, 1979
PYRIDOXAL-5'-PHOSPHATE INHIBITION OF PLATELET ...
ELIZABETH HARRIET. KORNECKI (7959149)
core   +6 more sources

Enzyme-Independent Interaction of Pyridoxal-5’-Phosphate with Cysteine [PDF]

, 2022
Pyridoxal-5′-phosphate (PLP), commonly known as Vitamin B6, is a versatile co-factor that assists in different types of enzymatic reactions. PLP has also been reported to react with substrates and catalyze some of these reactions independent of enzymes ...
Vijay, Krishna, Cindy, Chen, Prajakatta, Mulay   +2 more
core   +1 more source

Determination of pyridoxal phosphate and pyridoxal by the cyanohydrin method

Pyridoxal phosphate is a coenzyme in about 50 known enzymatic reactions. A simple and accurate method for the determination of pyridoxal phosphate would be desirable because it could provide a means to assess the nutritional status of vitamin B₆ in the ...
Chang, Susan Shao-Shu King
core   +6 more sources

Assembly of the eukaryotic PLP-synthase complex from plasmodium and activation of the Pdx1 enzyme [PDF]

, 2012
Biosynthesis of vitamins is fundamental to malaria parasites. Plasmodia synthesize the active form of vitamin B6 (pyridoxal 5-phosphate, PLP) using a PLP synthase complex.
Böttcher, Bettina, Derrer, Bianca, Windeisen, Volker, Hipp, Katharina, Tews, Ivo, Sinning, Irmgard, Kappes, Barbara, Boettcher, Bettina, Gengenbacher, Martin, Guedez, Gabriela   +9 more
core   +1 more source

Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6–dependent Epilepsy Than Pyridoxal 5′-Phosphate [PDF]

, 2020
Background We aimed to demonstrate the biochemical characteristics of vitamin B6–dependent epilepsy, with a particular focus on pyridoxal 5′-phosphate and pyridoxal in the cerebrospinal fluid. Methods Using our laboratory database, we identified patients
Ishihara, Naoko, Shimbo, Hiroko, Shibasaki, Jun, Dowa, Yuri, Takano, Kyoko, Fukuyama, Tetsuhiro, Hamano, Shin-ichiro, Kubota, Masaya, Takeshita, Saoko, Okanishi, Tohru, Baba, Shimpei, Akiyama, Tomoyuki, Shiraku, Hiroshi, Oboshi, Taikan, Yamamoto, Toshiyuki, Hyodo, Yuki, Koike, Takayoshi, Kobayashi, Katsuhiro, Hasegawa, Kosei, Imai, Katsumi   +19 more
core   +2 more sources

Variable treatment response in a patient with pyridoxal N phosphate oxidase (PNPO) deficiency- understanding the paradox

Epilepsy & Behavior Reports, 2020
A 6-year-old girl presented with history of infantile onset epileptic encephalopathy and developmental delay. She had polymorphic seizures that were refractory to regular anti-seizure medication.
Smilu Mohanlal, Parayil Sankaran Bindu, Sachin Sureshbabu, Suresh Kumar   +3 more
doaj   +1 more source

Circulating pyridoxal 5′-phosphate in serum and whole blood: implications for assessment of vitamin B6 status

Journal of Laboratory Medicine, 2023
Concentrations of pyridoxal 5′-phosphate (PLP) in serum and whole blood are routinely measured. The suitability of these markers in capturing vitamin B6 insufficiency is not well studied.
Obeid Rima, Möller Christoph, Geisel Jürgen   +2 more
doaj   +1 more source