Results 21 to 30 of about 805,988 (244)

Variable treatment response in a patient with pyridoxal N phosphate oxidase (PNPO) deficiency- understanding the paradox

Epilepsy & Behavior Reports, 2020
A 6-year-old girl presented with history of infantile onset epileptic encephalopathy and developmental delay. She had polymorphic seizures that were refractory to regular anti-seizure medication.
Smilu Mohanlal, Parayil Sankaran Bindu, Sachin Sureshbabu, Suresh Kumar   +3 more
doaj   +1 more source

Circulating pyridoxal 5′-phosphate in serum and whole blood: implications for assessment of vitamin B6 status

Journal of Laboratory Medicine, 2023
Concentrations of pyridoxal 5′-phosphate (PLP) in serum and whole blood are routinely measured. The suitability of these markers in capturing vitamin B6 insufficiency is not well studied.
Obeid Rima, Möller Christoph, Geisel Jürgen   +2 more
doaj   +1 more source

Supramolecular Tandem Assay for Pyridoxal‐5′‐phosphate by the Reporter Pair of Guanidinocalix[5]Arene and Fluorescein

ChemistryOpen, 2019
Guanidinocalix[5]arene and fluorescein reporter pair has been chosen to set up a supramolecular tandem assay principle based on the differential recognition of pyridoxal‐5′‐phosphate (the substrate of alkaline phosphatase, ALP), pyridoxal (the product of
Yu‐Xin Yue, Yong Kong, Fan Yang, Zhe Zheng, Xin‐Yue Hu, Dong‐Sheng Guo   +5 more
doaj   +1 more source

Cyclofaulknamycin with the Rare Amino Acid D-capreomycidine Isolated from a Well-Characterized Streptomyces albus Strain

Microorganisms, 2021
Targeted genome mining is an efficient method of biosynthetic gene cluster prioritization within constantly growing genome databases. Using two capreomycidine biosynthesis genes, alpha-ketoglutarate-dependent arginine beta-hydroxylase and pyridoxal ...
Liliya Horbal, Marc Stierhof, Anja Palusczak, Nikolas Eckert, Josef Zapp, Andriy Luzhetskyy   +5 more
doaj   +1 more source

Current Advances on Structure-Function Relationships of Pyridoxal 5′-Phosphate-Dependent Enzymes

Frontiers in Molecular Biosciences, 2019
Pyridoxal 5′-phosphate (PLP) functions as a coenzyme in many enzymatic processes, including decarboxylation, deamination, transamination, racemization, and others.
Jing Liang, Q. Han, Yang Tan, H. Ding, Jianyong Li   +4 more
semanticscholar   +1 more source

Pyridoxine dependent epilepsies: new therapeutical point of view

Italian Journal of Pediatrics, 2017
Pyridoxine dependent epilepsies (PDEs) are rare autosomal recessive disorders with onset in neonatal period. Seizures are typically not responsive to conventional antiepileptic drugs, but they cease after parental pyridoxine administration.
Raffaele Falsaperla, Giovanni Corsello
doaj   +1 more source

PLP Induced Inhibition of Thymidylate Synthase Activity in T Lymphocytes

European Journal of Inflammation, 2003
The present study was undertaken in order to examine whether pyridoxine may be used as an inhibitor of thymidylate synthase, and thus, as an antiproliferative agent.
M. Palasopoulou, C. Haitoglou, G. Papageorgiou, A. Dimitriadou   +3 more
doaj   +1 more source

PDXK mutations cause polyneuropathy responsive to pyridoxal 5′‐phosphate supplementation

Annals of Neurology, 2019
To identify disease‐causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy.
V. Chelban, M. Wilson, J. Warman Chardon, J. Vandrovcova, M. N. Zanetti, E. Zamba-Papanicolaou, S. Efthymiou, S. Pope, M. Conte, G. Abis, Yo-Tsen Liu, Eloise Tribollet, Nourelhoda A. Haridy, J. Botía, M. Ryten, P. Nicolaou, A. Minaidou, K. Christodoulou, K. Kernohan, Alison J Eaton, M. Osmond, Yoko A. Ito, P. Bourque, J. Jepson, O. Bello, F. Bremner, C. Cordivari, M. Reilly, M. Foiani, A. Heslegrave, H. Zetterberg, S. Heales, N. Wood, James E. Rothman, K. Boycott, P. Mills, P. Clayton, H. Houlden, Yamna Mohamed El Mhammed Stanislav Blagovesta Lionel Wol Kriouile Khorassani Aguennouz Groppa Marinova Kara, Y. Kriouile, M. Khorassani, M. Aguennouz, Stanislav Groppa, Blagovesta Marinova Karashova, L. Van Maldergem, W. Nachbauer, S. Boesch, L. Arning, D. Timmann, B. Cormand, B. Pérez-Dueñas, Gabriella di Rosa, J. Goraya, T. Sultan, J. Mine, D. Avdjieva, H. Kathom, R. Tincheva, S. Banu, M. Pineda-Marfa, P. Veggiotti, Michel D. Ferrari, A. M. van den Maagdenberg, A. Verrotti, G. Marseglia, S. Savasta, M. García-Silva, A. M. Ruiz, Barbara H. Garavaglia, Eugenia Borgione, S. Portaro, B. M. Sánchez, Richard S. Boles, S. Papacostas, M. Vikelis, James E. Rothman, P. Giunti, H. Houlden, V. Chelban, V. Salpietro, E. Oconnor, S. Efthymiou, D. Kullmann, R. Kaiyrzhanov, Roisin Sullivan, Alaa Khan, W. Y. Yau, I. Hostettler, E. Papanicolaou, E. Dardiotis, S. Maqbool, Shahnaz Ibrahim, S. Kirmani, N. Rana, Osama M. Atawneh, Shen-Yang Lim, Farooq Shaikh, G. Koutsis, M. Breza, S. Mangano, C. Scuderi, Giovanna Morello, T. Stojkovic, E. Torti, M. Zollo, G. Heimer, Y. Dauvilliers, P. Striano, I. Al-Khawaja, Fuad Al-Mutairi, F. Alkuraya, Hamed Sherifa, M. Rizig, N. Okubadejo, O. Ojo, O. Oshinaike, K. Wahab, A. Bello, S. Abubakar, Y. Obiabo, E. Nwazor, O. Ekenze, U. Williams, A. Iyagba, L. Taiwo, M. Komolafe, O. Oguntunde, S. Pchelina, Konstantin Senkevich, Nourelhoda A. Haridy, C. Shashkin, Nazira Zharkynbekova, Kairgali Koneyev, Ganieva Manizha, Maksudjon Isrofilov, U. Guliyeva, Kamran Salayev, S. Khachatryan, S. Rossi, G. Silvestri, Thomas Bourinaris, G. Xiromerisiou, L. Fidani, C. Spanaki, A. Tucci   +144 more
semanticscholar   +1 more source

Stability-indicating HPLC-PDA assay for simultaneous determination of paracetamol, thiamine and pyridoxal phosphate in tablet formulations

Acta Pharmaceutica, 2019
With the increased number of multi-drug formulations, there is a need to develop new methods for simultaneous determinations of drugs. A precise, accurate and reliable liquid chromatographic method was developed for simultaneous determination of ...
Ali Amir, Athar Muhammad Makshoof, Ahmed Mahmood, Nadeem Kashif, Murtaza Ghulam, Farooq Umar, Salman Muhammad   +6 more
doaj   +1 more source

Comparing the sensitivity of pyridoxal-5-phosphate, homocysteine and neopterin in coronary heart disease

Pteridines, 2002
Blood serum pyridoxal-5-phosphate, homocysteine and neopterin concentrations have been examined in 30 healthy individuals and 87 patients with coronary heart disease, verified by coronary angiography.
Rudzite Vera, Jurika Edite, Kalnins Uldis, Erglis Andrejs, Trusinskis Karlis, Jegere Sanda, Frick Barbara, Fuchs Dietmar   +7 more
doaj   +1 more source