Results 21 to 30 of about 55,337 (248)

Significantly Elevated Levels of Plasma Nicotinamide, Pyridoxal, and Pyridoxamine Phosphate Levels in Obese Emirati Population: A Cross-Sectional Study

Molecules, 2020
Water-soluble vitamins like B3 (nicotinamide), B6 (pyridoxine), and B9 (folic acid) are of utmost importance in human health and disease, as they are involved in numerous critical metabolic reactions. Not surprisingly, deficiencies of these vitamins have
Ghada Rashad Ibrahim, Iltaf Shah, Salah Gariballa, Javed Yasin, James Barker, Syed Salman Ashraf   +5 more
doaj   +1 more source

Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family. [PDF]

, 2015
BackgroundIt is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to mitigate such metabolite damage.
Cooper, Arthur JL, Downs, Diana M, ElBadawi-Sidhu, Mona, Fiehn, Oliver, Gerdes, Svetlana, Hanson, Andrew D, Hodge-Hanson, Kelsey, Niehaus, Thomas D, Zhukov, Aleksey   +8 more
core   +2 more sources

Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5′-phosphate as the inhibitor

Journal of Lipid Research, 2006
Peroxidized phospholipid-mediated cytotoxity is involved in the pathophysiology of a number of diseases [i.e., the abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) found in the plasma of type 2 diabetic patients]. The PCOOH accumulation may
Ohki Higuchi, Kiyotaka Nakagawa, Tsuyoshi Tsuzuki, Toshihide Suzuki, Shinichi Oikawa, Teruo Miyazawa   +5 more
doaj   +1 more source

The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. [PDF]

PLoS ONE, 2013
BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.
Monique Albersen, Marjolein Bosma, Nine V V A M Knoers, Berna H B de Ruiter, Eugène F Diekman, Jessica de Ruijter, Wouter F Visser, Tom J de Koning, Nanda M Verhoeven-Duif   +8 more
doaj   +1 more source

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]

, 1998
Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L., Burnstock, Geoffrey, Camaioni, Emidio, Harden, T. Kendall, Jacobson, Kenneth A., Ji, Xiao-Duo, Kim, Heaok, Kim, Yong-Chul, King, Brian F., Mohanram, Arvind, Rychkov, Alexei, Wildman, Scott S.P., Yoburn, Joshua, Ziganshin, Airat U.   +13 more
core   +3 more sources

A comparative study of the electrochemical properties of vitamin B-6 related compounds at physiological pH [PDF]

, 2011
A comparative study of vitamin B6 group and related compounds in buffered solutions using electrochemical techniques has been performed at neutral pH.
A. Pocker, A. Temizer, A.E. Braunstein, A.J. Bard, A.J. Román, A.K. Lunn, C.M. Harris, C.M. Metzler, D. Manousek, E.E. Snell, H. Lund, J. Gonzalez-Rodríguez, J. Llor, J. Llor, J. M. Sevilla, J.M. Rodríguez Mellado, J.M. RodrÍguez Mellado, J.M. RodrÍguez Mellado, J.M. RodrÍguez Mellado, L. Camacho, M. Blázquez, M. Blázquez, M. Heyrovský, M. Stanulovic, M.L. Ahrens, M.S. Ibrahim, N.P. Bazhulina, P. Zuman, P. Zuman, R. Izquierdo, R. Izquierdo, R. Schwartz, S.G. Mairanoskii, T. Pineda, T. Pineda, T. Pineda, V. Mirceski, W.F. Wolkers, Y.V. Morozov   +38 more
core   +1 more source

Variable treatment response in a patient with pyridoxal N phosphate oxidase (PNPO) deficiency- understanding the paradox

Epilepsy & Behavior Reports, 2020
A 6-year-old girl presented with history of infantile onset epileptic encephalopathy and developmental delay. She had polymorphic seizures that were refractory to regular anti-seizure medication.
Smilu Mohanlal, Parayil Sankaran Bindu, Sachin Sureshbabu, Suresh Kumar   +3 more
doaj   +1 more source

Circulating pyridoxal 5′-phosphate in serum and whole blood: implications for assessment of vitamin B6 status

Journal of Laboratory Medicine, 2023
Concentrations of pyridoxal 5′-phosphate (PLP) in serum and whole blood are routinely measured. The suitability of these markers in capturing vitamin B6 insufficiency is not well studied.
Obeid Rima, Möller Christoph, Geisel Jürgen   +2 more
doaj   +1 more source

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases [PDF]

, 2019
Background: Pharmaceutical compounding of orphan active ingredients can offer cost-effective treatment to patients when no other drug product is available for a rare disease or during periods of drug product shortages.
Boussery, Koen, De Spiegeleer, Bart, Peeters, E, Remon, Jean Paul, Van Tongelen, Inge, Vanhoorne, Valérie, Vervaet, Chris, Wynendaele, Evelien   +7 more
core   +2 more sources

Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis [PDF]

, 2015
Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be ...
Andrey, Vovk, Contestabile, Roberto, DI SALVO, Martino Luigi, Garik, Mkrtchyan, Lucien, Bettendorff, Parroni, Alessia, Thilo, Kaehne, Vasily, Aleshin, Victoria, Bunik, Yulia, Parkhomenko   +9 more
core   +1 more source