Results 31 to 40 of about 805,988 (244)

Pyridoxal Phosphate vs Pyridoxine for Intractable Seizures

Pediatric Neurology Briefs, 2005
The efficacy of pyridoxal phosphate (PLP) compared to pyridoxine (PN) in the control of idiopathic intractable epilepsy was studied in 94 children, aged 8 months to 15 years, at the National Taiwan University Hospital, Taipei, Taiwan.
J Gordon Millichap
doaj   +1 more source

Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity. [PDF]

PLoS ONE, 2011
Despite intensive effort, the majority of the annotated Mycobacterium tuberculosis genome consists of genes encoding proteins of unknown or poorly understood function.
Ellene H Mashalidis, Tathagata Mukherjee, Paweł Sledź, Dijana Matak-Vinković, Helena Boshoff, Chris Abell, Clifton E Barry   +6 more
doaj   +1 more source

Cloning and Characterization of Pyridoxal Kinase from Geobacillus sp. H6a

Journal of Pure and Applied Microbiology, 2022
Pyridoxal kinase encoded by pdxK gene, is the important key enzyme in the salvage pathway of vitamin B6 biosynthesis. The enzyme catalyzes the phosphorylation of the 5′ alcohol groups of free form vitamin B6 into their 5′-phosphate forms that requires ...
Jumnong Pasri, Chamaiporn Champasri, Yanee Trongpanich   +2 more
doaj   +1 more source

Crystal structure of L-aspartate aminotransferase from Schizosaccharomyces pombe.

PLoS ONE, 2019
L-aspartate aminotransferase is a pyridoxal 5'-phosphate-dependent transaminase that catalyzes reversible transfer of an α-amino group from aspartate to α-ketoglutarate or from glutamate to oxaloacetate.
Soo Yeon Jeong, Hyeonseok Jin, Jeong Ho Chang   +2 more
doaj   +1 more source

Structural Basis of the Substrate Specificity and Enzyme Catalysis of a Papaver somniferum Tyrosine Decarboxylase

Frontiers in Molecular Biosciences, 2017
Tyrosine decarboxylase (TyDC), a type II pyridoxal 5′-phosphate decarboxylase, catalyzes the decarboxylation of tyrosine. Due to a generally high sequence identity to other aromatic amino acid decarboxylases (AAADs), primary sequence information is not ...
Huai Guan, Huai Guan, Huai Guan, Shuaibao Song, Shuaibao Song, Shuaibao Song, Howard Robinson, Jing Liang, Haizhen Ding, Jianyong Li, Qian Han, Qian Han, Qian Han   +12 more
doaj   +1 more source

It takes two to tango: defining an essential second active site in pyridoxal 5'-phosphate synthase. [PDF]

PLoS ONE, 2011
The prevalent de novo biosynthetic pathway of vitamin B6 involves only two enzymes (Pdx1 and Pdx2) that form an ornate multisubunit complex functioning as a glutamine amidotransferase.
Cyril Moccand, Markus Kaufmann, Teresa B Fitzpatrick   +2 more
doaj   +1 more source

Two-Photon Excited Fluorescence of NADH-Alcohol Dehydrogenase Complex in a Mixture with Bacterial Enzymes

Biomolecules, 2023
Thorough study of composition and fluorescence properties of a commercial reagent of active equine NAD-dependent alcohol dehydrogenase expressed and purified from E. coli has been carried out. Several experimental methods: spectral- and time-resolved two-
Ioanna A. Gorbunova, Maxim E. Sasin, Dmitry V. Yachkov, Denis A. Volkov, Alexei D. Vedyaykin, Andrey A. Nikiforov, Oleg S. Vasyutinskii   +6 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Synthesis, Structural Characterization, Cytotoxicity, and Antibacterial Properties of Gold(III) Complexes with Hydrazones Derived from Vitamin B₆

Inorganics
The rise in the number of cancer cases and the dissemination of strains with multiple drug resistance in the world pose a serious threat to public health care and human well-being.
Daria V. Petrova, Aleksandra K. Isagulieva, Olga N. Sineva, Vera S. Sadykova, Maksim N. Zavalishin, George A. Gamov   +5 more
doaj   +1 more source

MOLECULAR MECHANISMS UNDERLYING THERAPEUTIC ACTION OF VITAMIN B6

Фармация и фармакология (Пятигорск), 2023
The aim of the study was to analyze the molecular mechanisms that determine the possibility of using vitamin B6 in clinical practice for the correction of various pathological conditions.Materials and methods.
O. A. Zagubnaya, Y. R. Nartsissov
doaj   +1 more source