Results 11 to 20 of about 346,502 (202)

A Microprocedure for the Determination of 4-Pyridoxic Acid in Urine

Clinical Chemistry, 1964
Abstract A microprocedure for the estimation of urinary 4-pyridoxic acid which is apparently specific, yet simple enough for routine clinical use, has been adapted from the Fujita et al. (16-17) and Reddy et al. (22) procedures. Average values for urinary 4-pyridoxic acid for 7 women ranged from 3.8 to 6.9 µM/24 hr. by this method. These
Clara A Storvick
exaly   +3 more sources

Integrated Analysis of Proteomics and Metabolomics for Heat Stress in Chinese Holstein Cows [PDF]

Animals
Heat stress (HS) severely significantly reduces milk yield and causes substantial economic losses of dairy cows. TMT-based proteomes and an untargeted metabolomics approach were used to conduct the proteomics and metabolomics in heat-stressed (HS, n = 6)
Xiao Wang, Yinglin Yuan, Fen Pei, Jian Yang, Chenchen Wang, Peng Bao, Xiuxin Zhao, Huiming Liu, Hongding Gao, Minghai Hou, Yundong Gao, Jianbin Li, Dan Hao, Rongling Li   +13 more
doaj   +2 more sources

Population Physiologically-Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions. Ethical concerns often limit clinical pharmacology studies that have no direct therapeutic benefit in children, highlighting the value of PBPK model predictions.
Cleary Y, Prasad B, Ogungbenro K, Gertz M, Galetin A.   +4 more
europepmc   +2 more sources

Research on metabolic characteristics of multiple sclerosis [PDF]

Scientific Reports
By comparing the fecal metabolite profiles of multiple sclerosis patients with those of healthy controls, to screen for significantly different metabolites and provide a basis for the discovery of potential biomarkers; further analyze the molecular ...
Diyuan Wang, Wenguang Feng, Haibin Wang, Xuhua Ying, Wenqiang Cai, Longcheng Guo, Jinteng Hou, Tingjia Yang   +7 more
doaj   +2 more sources

A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]

J Inherit Metab Dis
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Christ S, Rossmann J, Richter S, Garbade S, Klinke G, Blau N, Hoffmann GF, Okun JG, Opladen T.   +8 more
europepmc   +2 more sources

Liver Transplantation in PNPO Deficiency: Management Challenges and Biological Lessons. [PDF]

JIMD Rep
ABSTRACT Pyridox(am)ine 5′ Phosphate Oxidase deficiency (PNPO) presents with refractory epilepsy responsive to treatment with pyridoxal 5′ phosphate (PLP) or pyridoxine. A 15‐year‐old boy with PNPO deficiency and cirrhosis underwent orthotopic liver transplantation for hepatocellular carcinoma without extra‐hepatic disease.
Webster R, Sankaran BP, Bandodkar S, Stormon M, Thomas G, Shun A, Bowen DG, Fielder T, Barclay P, Khalil Y, Mills P, Clayton P, Bhattacharya K.   +12 more
europepmc   +2 more sources

High-throughput untargeted metabolomic profiling of urinary biomarkers in acute myocarditis patients: a cross-sectional study [PDF]

Scientific Reports
Acute myocarditis, characterized by inflammatory myocardial injury, significantly risks heart failure and sudden death. Despite its severity, specific biomarkers are lacking.
Cui-mei Zhao, Xiu-zhen Long, Ke-yi Wang, Shao-xin Tian, Ying-ran Li, Wen-yuan Zhang   +5 more
doaj   +2 more sources

Correction: Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults [PDF]

Frontiers in Nutrition
Yazhao Mei, Ziyuan Wang, Li Shen, Zhenlin Zhang, Hua Yue, Hao Zhang, Jiemei Gu, Weiwei Hu, Shanshan Li, Chao Gao, Zhe Wei, Yang Xu, Jie Wang, Gao Gao, Chun Wang   +14 more
doaj   +2 more sources

Associations between systemic inflammation and cognitive trajectories post-stroke [PDF]

Scientific Reports
Our objective was to explore whether plasma inflammatory biomarkers and related metabolites in acute phase and 3 months after stroke were associated with different cognitive trajectories and with changes in cognition post-stroke.
Heidi Vihovde Sandvig, Ingvild Saltvedt, Trine Holt Edwin, Stina Aam, Katinka Nordheim Alme, Rannveig Sakshaug Eldholm, Stian Lydersen, Tom Eirik Mollnes, Ragnhild Munthe-Kaas, Per Magne Ueland, Arve Ulvik, Torgeir Wethal, Anne-Brita Knapskog   +12 more
doaj   +2 more sources

Blood metabolic profiling associated with a short-term intensive training period in elite male water polo athletes: an exploratory metabolomics study [PDF]

Journal of the International Society of Sports Nutrition
Objective This exploratory metabolomics pilot study employed non-targeted liquid chromatography–tandem mass spectrometry (LC‒MS/MS) to characterize serum metabolic profiles in elite male water polo athletes, thereby assessing physiological adaptation to ...
Zhuo Sun, Leilei Wang
doaj   +2 more sources